SERINC3

SERINC3
Identifiers
Aliases	SERINC3 , AIGP1, DIFF33, SBBI99, TDE, TDE1, TMS-1, serine incorporator 3
External IDs	OMIM: 607165; MGI: 1349457; HomoloGene: 38230; GeneCards: SERINC3; OMA:SERINC3 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q13.12 Start 44,496,221 bp [1] End 44,522,085 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H3 Start 163,465,192 bp [2] End 163,487,051 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell tendon of biceps brachii pons internal globus pallidus Brodmann area 23 middle temporal gyrus superior frontal gyrus stromal cell of endometrium postcentral gyrus prefrontal cortex Top expressed in lobe of prostate seminal vesicula stroma of bone marrow left lung lobe blood Paneth cell median eminence parotid gland Gonadal ridge crypt of lieberkuhn of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function L-serine transmembrane transporter activity Cellular component integral component of membrane Golgi membrane Golgi apparatus membrane cytoplasm perinuclear region of cytoplasm plasma membrane Biological process phosphatidylserine metabolic process detection of virus innate immune response defense response to virus positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway sphingolipid metabolic process L-serine transport immune system process L-serine biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10955 26943 Ensembl ENSG00000132824 ENSMUSG00000017707 UniProt Q13530 Q9QZI9 RefSeq (mRNA) NM_198941 NM_006811 NM_012032 RefSeq (protein) NP_006802 NP_945179 NP_036162 Location (UCSC) Chr 20: 44.5 – 44.52 Mb Chr 2: 163.47 – 163.49 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine incorporator 3 is a protein that in humans is encoded by the SERINC3 gene. ^{[5] [6]} It has been demonstrated that SERINC3 acts as a retrovirus restriction factor. ^{[7] [8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000132824 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000017707 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bossolasco M, Lebel M, Lemieux N, Mes-Masson AM (November 1999). "The human TDE gene homologue: localization to 20q13.1-13.3 and variable expression in human tumor cell lines and tissue". Molecular Carcinogenesis. 26 (3): 189–200. doi:10.1002/(SICI)1098-2744(199911)26:3<189::AID-MC8>3.0.CO;2-T. PMID   10559794. S2CID   19505445.
6. "Entrez Gene: SERINC3 serine incorporator 3".
7. Rosa A, Chande A, Ziglio S, De Sanctis V, Bertorelli R, Goh SL, McCauley SM, Nowosielska A, Antonarakis SE, Luban J, Santoni FA, Pizzato M (October 2015). "HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation". Nature. 526 (7572): 212–7. Bibcode:2015Natur.526..212R. doi:10.1038/nature15399. PMC   4861059 . PMID   26416734.
8. Chande A, Cuccurullo EC, Rosa A, Ziglio S, Carpenter S, Pizzato M (November 2016). "S2 from equine infectious anemia virus is an infectivity factor which counteracts the retroviral inhibitors SERINC5 and SERINC3". Proceedings of the National Academy of Sciences of the United States of America. 113 (46): 13197–13202. doi: 10.1073/pnas.1612044113 . PMC   5135340 . PMID   27803322.
9. Ramdas P, Bhardwaj V, Singh A, Vijay N, Chande A (2020-02-24). "Coevolution of retroviruses with SERINCs following whole-genome duplication divergence". bioRxiv. doi: 10.1101/2020.02.24.962506 .

Further reading

• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID   7566098.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Bossolasco M, Veillette F, Bertrand R, Mes-Masson AM (August 2006). "Human TDE1, a TDE1/TMS family member, inhibits apoptosis in vitro and stimulates in vivo tumorigenesis". Oncogene. 25 (33): 4549–58. doi:10.1038/sj.onc.1209488. PMID   16547497. S2CID   24696947.