SERP1

SERP1
Identifiers
Aliases	SERP1 , RAMP4, stress-associated endoplasmic reticulum protein 1, stress associated endoplasmic reticulum protein 1
External IDs	OMIM: 617674; MGI: 92638; HomoloGene: 8691; GeneCards: SERP1; OMA:SERP1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q25.1 Start 150,541,998 bp [1] End 150,603,228 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3 D|3 28.58 cM Start 58,427,238 bp [2] End 58,433,313 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland corpus epididymis body of pancreas caput epididymis bronchial epithelial cell amniotic fluid palpebral conjunctiva mucosa of paranasal sinus superficial temporal artery lower lobe of lung Top expressed in parotid gland seminal vesicula lacrimal gland submandibular gland crypt of lieberkuhn of small intestine olfactory epithelium lymph node mesenteric lymph nodes calvaria pyloric antrum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane cytosol ribosome endoplasmic reticulum membrane membrane endoplasmic reticulum cytoplasmic microtubule Biological process skeletal system development muscle organ morphogenesis positive regulation of organ growth post-embryonic development positive regulation of translation IRE1-mediated unfolded protein response positive regulation of growth hormone secretion glucose metabolic process multicellular organism aging protein transport plasma membrane organization positive regulation of insulin secretion endoplasmic reticulum unfolded protein response protein glycosylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27230 28146 Ensembl ENSG00000120742 ENSMUSG00000027808 UniProt Q9Y6X1 Q9Z1W5 RefSeq (mRNA) NM_014445 NM_030685 RefSeq (protein) NP_055260 NP_109610 Location (UCSC) Chr 3: 150.54 – 150.6 Mb Chr 3: 58.43 – 58.43 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Stress-associated endoplasmic reticulum protein 1 is a protein that in humans is encoded by the SERP1 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000120742 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027808 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yamaguchi A, Hori O, Stern DM, Hartmann E, Ogawa S, Tohyama M (Jan 2000). "Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation". J Cell Biol. 147 (6): 1195–204. doi:10.1083/jcb.147.6.1195. PMC   2168098 . PMID   10601334.
6. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
7. "Entrez Gene: SERP1 stress-associated endoplasmic reticulum protein 1".

Further reading

• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi: 10.1073/pnas.160270997 . PMC   16901 . PMID   10931946.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.