SERPINI2

SERPINI2
Identifiers
Aliases	SERPINI2 , MEPI, PANCPIN, PI14, TSA2004, serpin family I member 2
External IDs	OMIM: 605587; MGI: 1915181; HomoloGene: 21248; GeneCards: SERPINI2; OMA:SERPINI2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q26.1 Start 167,441,914 bp [1] End 167,478,972 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 E3 Start 75,149,677 bp [2] End 75,177,385 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas right uterine tube bronchial epithelial cell testicle islet of Langerhans olfactory zone of nasal mucosa pancreatic epithelial cell mucosa of paranasal sinus monocyte caudate nucleus Top expressed in pyloric antrum pancreas islet of Langerhans embryo embryo migratory enteric neural crest cell duodenum right ventricle lumbar subsegment of spinal cord spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity protein binding serine-type endopeptidase inhibitor activity Cellular component extracellular region extracellular exosome extracellular space Biological process negative regulation of peptidase activity negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5276 67931 Ensembl ENSG00000114204 ENSMUSG00000034139 UniProt O75830 Q9JK88 RefSeq (mRNA) NM_006217 NM_001012303 NM_001394327 NM_026460 RefSeq (protein) NP_001012303 NP_006208 NP_080736 Location (UCSC) Chr 3: 167.44 – 167.48 Mb Chr 3: 75.15 – 75.18 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serpin I2 is a protein that in humans is encoded by the SERPINI2 gene. ^{[5] [6]}

Function

The protein encoded by this gene is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000114204 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034139 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ozaki K, Nagata M, Suzuki M, Fujiwara T, Miyoshi Y, Ishikawa O, Ohigashi H, Imaoka S, Takahashi E, Nakamura Y (July 1998). "Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells". Genes, Chromosomes & Cancer. 22 (3): 179–85. doi:10.1002/(SICI)1098-2264(199807)22:3<179::AID-GCC3>3.0.CO;2-T. PMID   9624529. S2CID   9525421.
6. "Entrez Gene: SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2".

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Xiao G, Liu YE, Gentz R, Sang QA, Ni J, Goldberg ID, Shi YE (March 1999). "Suppression of breast cancer growth and metastasis by a serpin myoepithelium-derived serine proteinase inhibitor expressed in the mammary myoepithelial cells". Proceedings of the National Academy of Sciences of the United States of America. 96 (7): 3700–5. Bibcode:1999PNAS...96.3700X. doi: 10.1073/pnas.96.7.3700 . PMC   22357 . PMID   10097100.
• Chang WS, Chang NT, Lin SC, Wu CW, Wu FY (November 2000). "Tissue-specific cancer-related serpin gene cluster at human chromosome band 3q26". Genes, Chromosomes & Cancer. 29 (3): 240–55. doi:10.1002/1098-2264(2000)9999:9999<::AID-GCC1029>3.0.CO;2-A. PMID   10992299. S2CID   23441111.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.

External links

• The MEROPS online database for peptidases and their inhibitors: I04.026