SESTD1

SESTD1
Identifiers
Aliases	SESTD1 , SOLO, SEC14 and spectrin domain containing 1
External IDs	MGI: 1916262 HomoloGene: 45505 GeneCards: SESTD1
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q31.2 Start 179,101,678 bp [1] End 179,264,832 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 C3 Start 77,010,684 bp [2] End 77,110,936 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon corpus callosum gastric mucosa inferior ganglion of vagus nerve subthalamic nucleus secondary oocyte pancreatic ductal cell subcutaneous adipose tissue popliteal artery globus pallidus Top expressed in otolith organ utricle trigeminal ganglion hand medial dorsal nucleus Paneth cell lateral geniculate nucleus medial geniculate nucleus spinal ganglia cerebellar vermis More reference expression data BioGPS n/a
Gene ontology Molecular function phosphatidic acid binding phosphatidylinositol-4-phosphate binding phosphatidylinositol-5-phosphate binding phosphatidylinositol-4,5-bisphosphate binding 1-phosphatidylinositol binding protein binding phosphatidylserine binding phosphatidylinositol-3-phosphate binding phosphatidylinositol-3,5-bisphosphate binding phosphatidylcholine binding phosphatidylinositol-3,4-bisphosphate binding Cellular component calcium channel complex intermediate filament cytoskeleton Biological process negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 91404 228071 Ensembl ENSG00000187231 ENSMUSG00000042272 UniProt Q86VW0 Q80UK0 RefSeq (mRNA) NM_178123 NM_175465 RefSeq (protein) NP_835224 NP_780674 Location (UCSC) Chr 2: 179.1 – 179.26 Mb Chr 2: 77.01 – 77.11 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SEC14 and spectrin domains 1, also known as SEC14 domain and spectrin repeat-containing protein 1 and Solo, is a protein that in humans is encoded by the SESTD1 gene. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000187231 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042272 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SEC14 and spectrin domains 1".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Sato T, Mishina M (2003). "Representational difference analysis, high-resolution physical mapping, and transcript identification of the zebrafish genomic region for a motor behavior". Genomics. 82 (2): 218–29. doi:10.1016/S0888-7543(03)00071-5. PMID   12837271.
• Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC   2896464 . PMID   20379614.
• Miehe S, Bieberstein A, Arnould I, et al. (2010). "The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5". J. Biol. Chem. 285 (16): 12426–34. doi: 10.1074/jbc.M109.068304 . PMC   2852980 . PMID   20164195.
• Trynka G, Zhernakova A, Romanos J, et al. (2009). "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling". Gut. 58 (8): 1078–83. doi:10.1136/gut.2008.169052. PMID   19240061. S2CID   17111427.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.