SF1 (gene)

SF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1K1G, 1O0P, 1OPI, 2M09, 4FXW, 4FXX
Identifiers
Aliases	SF1 , BBP, D11S636, MBBP, ZCCHC25, ZFM1, ZNF162, splicing factor 1
External IDs	OMIM: 601516; MGI: 1095403; HomoloGene: 138518; GeneCards: SF1; OMA:SF1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	64,778,786 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; left ovary; ; tibial nerve; ; gastric mucosa; ; right ovary; ; right lobe of thyroid gland; ; left uterine tube; ; canal of the cervix; ; right hemisphere of cerebellum; ; left lobe of thyroid gland;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription corepressor activity ; zinc ion binding ; metal ion binding ; protein binding ; nucleic acid binding ; identical protein binding ; pre-mRNA branch point binding ; RNA binding ;
Cellular component	ribosome ; spliceosomal complex ; nucleus ; nucleoplasm ; nuclear body ;
Biological process	negative regulation of smooth muscle cell proliferation ; regulation of transcription, DNA-templated ; Leydig cell differentiation ; mRNA processing ; regulation of steroid biosynthetic process ; male sex determination ; transcription, DNA-templated ; spliceosomal complex assembly ; mRNA 3'-splice site recognition ; RNA splicing ; negative regulation of nucleic acid-templated transcription ; mRNA splicing, via spliceosome ; nuclear body organization ;
	Sources:Amigo / QuickGO
Orthologs
	7536
	22668
	ENSG00000168066
	ENSMUSG00000024949
	Q15637
	Q64213
NM_001178030 ; NM_001178031 ; NM_004630 ; NM_201995 ; NM_201997 ;
	NM_201998 ; NM_001346363 ; NM_001346364 ; NM_001346409 ; NM_001346410 ; NM_001378956 ; NM_001378957 Contents Interactions ; References ; Further reading ;
	NM_001110791 ; NM_011750
NP_001171501 ; NP_001171502 ; NP_001333292 ; NP_001333293 ; NP_001333338 ;
	NP_001333339 ; NP_004621 ; NP_973724 ; NP_973726 ; NP_973727 ; NP_001365885 ; NP_001365886
NP_001104261 ; NP_035880 ; NP_001347322 ; NP_001390363 ; NP_001390364 ;
	NP_001390365 ; NP_001390368 ; NP_001390369 ; NP_001390370 ; NP_001390371 ; NP_001390372 ; NP_001390373 ; NP_001390374 ; NP_001390375 ; NP_001390376 ; NP_001390377 ; NP_001390378
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2024

Splicing factor 1 also known as zinc finger protein 162 (ZFM162) is a protein that in humans is encoded by the SF1 gene.^[4]^[5]^[6]

Splicing factor SF1 is involved in the ATP-dependent formation of the spliceosome complex.^[7] SF1 gene is necessary to make the bipotential gonad; but while SF1 levels decline in the genital ridge of XX mouse embryos, the SF1 gene stays on the developing testes. SF 1 (transcription factor) appears to be active in masculining both the Leydig cells and Sertoli cells. In Sertoli cells with the SOX9 protein it elevates the level of AMH transcription. In Leydig cells it activates the gene encoding the enzyme that make testosterone hormone.

Interactions

SF1 (gene) has been shown to interact with Ewing sarcoma breakpoint region 1,^[8] U2AF2,^[9]^[10]^[11] Testis determining factor,^[12] and transcription elongation regulator 1.^[13]

Related Research Articles

RNA splicing is a process in molecular biology where a newly-made precursor messenger RNA (pre-mRNA) transcript is transformed into a mature messenger RNA (mRNA). It works by removing all the introns and splicing back together exons. For nuclear-encoded genes, splicing occurs in the nucleus either during or immediately after transcription. For those eukaryotic genes that contain introns, splicing is usually needed to create an mRNA molecule that can be translated into protein. For many eukaryotic introns, splicing occurs in a series of reactions which are catalyzed by the spliceosome, a complex of small nuclear ribonucleoproteins (snRNPs). There exist self-splicing introns, that is, ribozymes that can catalyze their own excision from their parent RNA molecule. The process of transcription, splicing and translation is called gene expression, the central dogma of molecular biology.

A spliceosome is a large ribonucleoprotein (RNP) complex found primarily within the nucleus of eukaryotic cells. The spliceosome is assembled from small nuclear RNAs (snRNA) and numerous proteins. Small nuclear RNA (snRNA) molecules bind to specific proteins to form a small nuclear ribonucleoprotein complex, which in turn combines with other snRNPs to form a large ribonucleoprotein complex called a spliceosome. The spliceosome removes introns from a transcribed pre-mRNA, a type of primary transcript. This process is generally referred to as splicing. An analogy is a film editor, who selectively cuts out irrelevant or incorrect material from the initial film and sends the cleaned-up version to the director for the final cut.

Splicing factor U2AF 65 kDa subunit is a protein that in humans is encoded by the U2AF2 gene.

Cux1 is a homeodomain protein that in humans is encoded by the CUX1 gene.

Probable ATP-dependent RNA helicase DDX5 also known as DEAD box protein 5 or RNA helicase p68 is an enzyme that in humans is encoded by the DDX5 gene.

General transcription factor IIH subunit 4 is a protein that in humans is encoded by the GTF2H4 gene.

Splicing factor 3 subunit 1 is a protein that in humans is encoded by the SF3A1 gene.

Transcription initiation factor TFIID subunit 2 is a protein that in humans is encoded by the TAF2 gene.

HIV Tat-specific factor 1 is a protein that in humans is encoded by the HTATSF1 gene.

Transcription factor IIIB 90 kDa subunit is a protein that in humans is encoded by the BRF1 gene.

Splicing factor 3A subunit 3 is a protein that in humans is encoded by the SF3A3 gene.

TATA-binding protein-associated factor 2N is a protein that in humans is encoded by the TAF15 gene.

Transcription elongation regulator 1, also known as TCERG1, is a protein which in humans is encoded by the TCERG1 gene.

Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene.

Pre-mRNA-processing factor 6 is a protein that in humans is encoded by the PRPF6 gene.

U4/U6 small nuclear ribonucleoprotein Prp4 is a protein that in humans is encoded by the PRPF4 gene. The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF4 is 1 of several proteins that associate with U4 and U6 snRNPs.[supplied by OMIM]

General transcription factor IIF subunit 1 is a protein that in humans is encoded by the GTF2F1 gene.

General transcription factor IIF subunit 2 is a protein that in humans is encoded by the GTF2F2 gene.

Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the SFRS11 gene.

Pre-mRNA-splicing factor SLU7 is a protein that in humans is encoded by the SLU7 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000168066 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Toda T, Iida A, Miwa T, Nakamura Y, Imai T (Jul 1994). "Isolation and characterization of a novel gene encoding nuclear protein at a locus (D11S636) tightly linked to multiple endocrine neoplasia type 1 (MEN1)". Hum Mol Genet. 3 (3): 465–70. doi:10.1093/hmg/3.3.465. PMID 7912130.
↑ Kramer A, Quentin M, Mulhauser F (Jun 1998). "Diverse modes of alternative splicing of human splicing factor SF-1 deduced from the exon-intron structure of the gene". Gene. 211 (1): 29–37. doi:10.1016/S0378-1119(98)00058-4. PMID 9573336.
↑ "Entrez Gene: SF1 splicing factor 1".
↑ Rino J, Desterro JM, Pacheco TR, Gadella TW, Carmo-Fonseca M (May 2008). "Splicing factors SF1 and U2AF associate in extraspliceosomal complexes". Mol. Cell. Biol. 28 (9): 3045–57. doi:10.1128/MCB.02015-07. PMC 2293075 . PMID 18285458.
↑ Zhang D, Paley AJ, Childs G (July 1998). "The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription". J. Biol. Chem. 273 (29): 18086–91. doi: 10.1074/jbc.273.29.18086 . PMID 9660765.
↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
↑ Berglund JA, Abovich N, Rosbash M (March 1998). "A cooperative interaction between U2AF65 and mBBP/SF1 facilitates branchpoint region recognition". Genes Dev. 12 (6): 858–67. doi:10.1101/gad.12.6.858. PMC 316625 . PMID 9512519.
↑ Abovich N, Rosbash M (May 1997). "Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals". Cell. 89 (3): 403–12. doi: 10.1016/S0092-8674(00)80221-4 . PMID 9150140. S2CID 18466775.
↑ Kashimada K, Koopman P (December 2010). "Sry: the master switch in mammalian sex determination". Development. 137 (23): 3921–30. doi: 10.1242/dev.048983 . PMID 21062860.
↑ Goldstrohm AC, Albrecht TR, Suñé C, Bedford MT, Garcia-Blanco MA (November 2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. 21 (22): 7617–28. doi:10.1128/MCB.21.22.7617-7628.2001. PMC 99933 . PMID 11604498.

Krämer A (1992). "Purification of splicing factor SF1, a heat-stable protein that functions in the assembly of a presplicing complex". Mol. Cell. Biol. 12 (10): 4545–52. doi:10.1128/MCB.12.10.4545. PMC 360381 . PMID 1406644.
Naumovski L, Cleary ML (1996). "The p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/M". Mol. Cell. Biol. 16 (7): 3884–92. doi:10.1128/MCB.16.7.3884. PMC 231385 . PMID 8668206.
Arning S, Grüter P, Bilbe G, Krämer A (1996). "Mammalian splicing factor SF1 is encoded by variant cDNAs and binds to RNA". RNA. 2 (8): 794–810. PMC 1369416 . PMID 8752089.
Abovich N, Rosbash M (1997). "Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals". Cell. 89 (3): 403–12. doi: 10.1016/S0092-8674(00)80221-4 . PMID 9150140. S2CID 18466775.
Caslini C, Spinelli O, Cazzaniga G, et al. (1997). "Identification of two novel isoforms of the ZNF162 gene: a growing family of signal transduction and activator of RNA proteins". Genomics. 42 (2): 268–77. doi:10.1006/geno.1997.4705. PMID 9192847.
Zhang D, Childs G (1998). "Human ZFM1 protein is a transcriptional repressor that interacts with the transcription activation domain of stage-specific activator protein". J. Biol. Chem. 273 (12): 6868–77. doi: 10.1074/jbc.273.12.6868 . PMID 9506990.
Berglund JA, Abovich N, Rosbash M (1998). "A cooperative interaction between U2AF65 and mBBP/SF1 facilitates branchpoint region recognition". Genes Dev. 12 (6): 858–67. doi:10.1101/gad.12.6.858. PMC 316625 . PMID 9512519.
Zhang D, Paley AJ, Childs G (1998). "The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription". J. Biol. Chem. 273 (29): 18086–91. doi: 10.1074/jbc.273.29.18086 . PMID 9660765.
Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529. S2CID 585778.
Wang X, Bruderer S, Rafi Z, et al. (1999). "Phosphorylation of splicing factor SF1 on Ser20 by cGMP-dependent protein kinase regulates spliceosome assembly". EMBO J. 18 (16): 4549–59. doi:10.1093/emboj/18.16.4549. PMC 1171529 . PMID 10449420.
Lapteva N, Nieda M, Ando Y, et al. (2001). "Expression of renin-angiotensin system genes in immature and mature dendritic cells identified using human cDNA microarray". Biochem. Biophys. Res. Commun. 285 (4): 1059–65. doi:10.1006/bbrc.2001.5215. PMID 11467860.
Goldstrohm AC, Albrecht TR, Suñé C, et al. (2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. 21 (22): 7617–28. doi:10.1128/MCB.21.22.7617-7628.2001. PMC 99933 . PMID 11604498.
Liu Z, Luyten I, Bottomley MJ, et al. (2001). "Structural basis for recognition of the intron branch site RNA by splicing factor 1". Science. 294 (5544): 1098–102. Bibcode:2001Sci...294.1098L. doi:10.1126/science.1064719. PMID 11691992. S2CID 21402023.
Rappsilber J, Ryder U, Lamond AI, Mann M (2002). "Large-scale proteomic analysis of the human spliceosome". Genome Res. 12 (8): 1231–45. doi:10.1101/gr.473902. PMC 186633 . PMID 12176931.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Selenko P, Gregorovic G, Sprangers R, et al. (2003). "Structural basis for the molecular recognition between human splicing factors U2AF65 and SF1/mBBP". Mol. Cell. 11 (4): 965–76. doi: 10.1016/S1097-2765(03)00115-1 . PMID 12718882.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Lin KT, Lu RM, Tarn WY (2004). "The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo". Mol. Cell. Biol. 24 (20): 9176–85. doi:10.1128/MCB.24.20.9176-9185.2004. PMC 517884 . PMID 15456888.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000168066 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7912130-4] Toda T, Iida A, Miwa T, Nakamura Y, Imai T (Jul 1994). "Isolation and characterization of a novel gene encoding nuclear protein at a locus (D11S636) tightly linked to multiple endocrine neoplasia type 1 (MEN1)". Hum Mol Genet. 3 (3): 465–70. doi:10.1093/hmg/3.3.465. PMID 7912130.

[pmid9573336-5] Kramer A, Quentin M, Mulhauser F (Jun 1998). "Diverse modes of alternative splicing of human splicing factor SF-1 deduced from the exon-intron structure of the gene". Gene. 211 (1): 29–37. doi:10.1016/S0378-1119(98)00058-4. PMID 9573336.

[entrez-6] "Entrez Gene: SF1 splicing factor 1".

[pmid18285458-7] Rino J, Desterro JM, Pacheco TR, Gadella TW, Carmo-Fonseca M (May 2008). "Splicing factors SF1 and U2AF associate in extraspliceosomal complexes". Mol. Cell. Biol. 28 (9): 3045–57. doi:10.1128/MCB.02015-07. PMC 2293075 . PMID 18285458.

[pmid9660765-8] Zhang D, Paley AJ, Childs G (July 1998). "The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription". J. Biol. Chem. 273 (29): 18086–91. doi: 10.1074/jbc.273.29.18086 . PMID 9660765.

[pmid16189514-9] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[pmid9512519-10] Berglund JA, Abovich N, Rosbash M (March 1998). "A cooperative interaction between U2AF65 and mBBP/SF1 facilitates branchpoint region recognition". Genes Dev. 12 (6): 858–67. doi:10.1101/gad.12.6.858. PMC 316625 . PMID 9512519.

[pmid9150140-11] Abovich N, Rosbash M (May 1997). "Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals". Cell. 89 (3): 403–12. doi: 10.1016/S0092-8674(00)80221-4 . PMID 9150140. S2CID 18466775.

[Kashimada_Koopman_2010-12] Kashimada K, Koopman P (December 2010). "Sry: the master switch in mammalian sex determination". Development. 137 (23): 3921–30. doi: 10.1242/dev.048983 . PMID 21062860.

[pmid11604498-13] Goldstrohm AC, Albrecht TR, Suñé C, Bedford MT, Garcia-Blanco MA (November 2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. 21 (22): 7617–28. doi:10.1128/MCB.21.22.7617-7628.2001. PMC 99933 . PMID 11604498.

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SF1 (gene)

Contents

Interactions

Related Research Articles

References

Further reading