Transcription elongation regulator 1

Last updated
TCERG1
Protein TCERG1 PDB 1e0l.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TCERG1 , CA150, TAF2S, Urn1, transcription elongation regulator 1
External IDs OMIM: 605409; MGI: 1926421; HomoloGene: 4879; GeneCards: TCERG1; OMA:TCERG1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001040006
NM_006706
NM_001382548

NM_001039474
NM_001289526
NM_001360881
NM_019512

RefSeq (protein)

NP_001035095
NP_006697
NP_001369477

NP_001034563
NP_001276455
NP_001347810

Location (UCSC) Chr 5: 146.45 – 146.51 Mb Chr 18: 42.64 – 42.71 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription elongation regulator 1, also known as TCERG1, is a protein which in humans is encoded by the TCERG1 gene. [5] [6] [7]

Function

This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms. [5]

Interactions

Transcription elongation regulator 1 has been shown to interact with SF1 [8] and POLR2A. [9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000113649 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024498 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: TCERG1 transcription elongation regulator 1".
  6. Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA (October 1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Molecular and Cellular Biology. 17 (10): 6029–39. doi:10.1128/MCB.17.10.6029. PMC   232452 . PMID   9315662.
  7. Bohne J, Cole SE, Suñe C, Lindman BR, Ko VD, Vogt TF, Garcia-Blanco MA (October 2000). "Expression analysis and mapping of the mouse and human transcriptional regulator CA150". Mammalian Genome. 11 (10): 930–3. doi:10.1007/s003350010162. PMID   11003711. S2CID   2396234.
  8. Goldstrohm, A C; Albrecht T R; Suñé C; Bedford M T; Garcia-Blanco M A (November 2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. 21 (22): 7617–28. doi:10.1128/MCB.21.22.7617-7628.2001. ISSN   0270-7306. PMC   99933 . PMID   11604498.
  9. Carty, S M; Goldstrohm A C; Suñé C; Garcia-Blanco M A; Greenleaf A L (August 2000). "Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9015–20. Bibcode:2000PNAS...97.9015C. doi: 10.1073/pnas.160266597 . ISSN   0027-8424. PMC   16813 . PMID   10908677.

Further reading