SFRP5

SFRP5
Identifiers
Aliases	SFRP5 , SARP3, secreted frizzled related protein 5
External IDs	OMIM: 604158 MGI: 1860298 HomoloGene: 2268 GeneCards: SFRP5
Gene location (Human)
Chr.	Chromosome 10 (human)
End	97,771,999 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	42,190,691 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; tibial nerve; ; body of pancreas; ; sural nerve; ; olfactory bulb; ; duodenum; ; trigeminal ganglion; ; spinal ganglia; ; tibia; ; inferior olivary nucleus;
	Top expressed in
	sciatic nerve; ; lacrimal gland; ; islet of Langerhans; ; parotid gland; ; retinal pigment epithelium; ; white adipose tissue; ; subcutaneous adipose tissue; ; extraocular muscle; ; lip; ; morula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity ; Wnt-protein binding ; Wnt-activated receptor activity ;
Cellular component	extracellular region ; extracellular space ; integral component of membrane ;
Biological process	cell differentiation ; negative regulation of protein kinase B signaling ; negative regulation of Wnt signaling pathway ; anatomical structure morphogenesis ; Wnt signaling pathway ; negative regulation of DNA-binding transcription factor activity ; multicellular organism development ; establishment or maintenance of cell polarity ; negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis ; negative regulation of canonical Wnt signaling pathway ; signal transduction ; visual perception ; negative regulation of cell population proliferation ; apoptotic process ; regulation of Wnt signaling pathway ; regulation of BMP signaling pathway ; G protein-coupled receptor signaling pathway ; non-canonical Wnt signaling pathway ; canonical Wnt signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	6425
	54612
	ENSG00000120057
	ENSMUSG00000018822
	Q5T4F7
	Q9WU66
	NM_003015
	NM_018780
	NP_003006
	NP_061250
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2022

Secreted frizzled-related protein 5 is a protein that in humans is encoded by the SFRP5 gene.^[5]^[6]

Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas.^[6]

Related Research Articles

Excitatory amino-acid transporter 5 (EAAT5) is a protein that in humans is encoded by the SLC1A7 gene.

Frizzled-2(Fz-2) is a protein that in humans is encoded by the FZD2 gene.

Frizzled-5(Fz-5) is a protein that in humans is encoded by the FZD5 gene.

Frizzled-3(Fz-3) is a protein that in humans is encoded by the FZD3 gene.

Frizzled-7(Fd-7) is a protein that in humans is encoded by the FZD7 gene.

Frizzled-8(Fz-8) is a protein that in humans is encoded by the FZD8 gene.

Secreted frizzled-related protein 1, also known as SFRP1, is a protein which in humans is encoded by the SFRP1 gene.

Interleukin-18-binding protein is a protein that in humans is encoded by the IL18BP gene.

Secreted frizzled-related protein 2 is a protein that in humans is encoded by the SFRP2 gene. This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.

Protein Wnt-7a is a protein that in humans is encoded by the WNT7A gene.

Segment polarity protein dishevelled homolog DVL-2 is a protein that in humans is encoded by the DVL2 gene.

Secreted frizzled-related protein 4 is a protein that in humans is encoded by the SFRP4 gene.

Proto-oncogene protein Wnt-3 is a protein that in humans is encoded by the WNT3 gene.

Mucin-like protein 1 is a protein that in humans is encoded by the MUCL1 gene.

Disheveled-associated activator of morphogenesis 1 is a protein that in humans is encoded by the DAAM1 gene. Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined.

R-spondin-1 is a secreted protein that in humans is encoded by the Rspo1 gene, found on chromosome 1. In humans, it interacts with WNT4 in the process of female sex development. Loss of function can cause female to male sex reversal. Furthermore, it promotes canonical WNT/β catenin signaling.

FRAS1-related extracellular matrix protein 2 is a protein that in humans is encoded by the FREM2 gene.

Protein Wnt-5b is a protein that in humans is encoded by the WNT5B gene.

Membrane frizzled-related protein is a protein that in humans is encoded by the MFRP gene.

Beta-defensin 129 is a protein that in humans is encoded by the DEFB129 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000120057 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018822 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Melkonyan HS, Chang WC, Shapiro JP, Mahadevappa M, Fitzpatrick PA, Kiefer MC, Tomei LD, Umansky SR (Jan 1998). "SARPs: A family of secreted apoptosis-related proteins". Proc Natl Acad Sci U S A. 94 (25): 13636–41. doi: 10.1073/pnas.94.25.13636 . PMC 28358 . PMID 9391078.
1 2 "Entrez Gene: SFRP5 secreted frizzled-related protein 5".

Veeck J, Geisler C, Noetzel E, et al. (2008). "Epigenetic inactivation of the Secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosis". Carcinogenesis. 29 (5): 991–998. doi: 10.1093/carcin/bgn076 . PMID 18356147.
Urakami S, Shiina H, Enokida H, et al. (2006). "Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection". Clin. Cancer Res. 12 (7 Pt 1): 2109–16. doi: 10.1158/1078-0432.CCR-05-2468 . PMID 16609023.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID 15164054.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Chang JT, Esumi N, Moore K, et al. (1999). "Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium". Hum. Mol. Genet. 8 (4): 575–83. doi: 10.1093/hmg/8.4.575 . PMID 10072424.
Hu E, Zhu Y, Fredrickson T, et al. (1998). "Tissue restricted expression of two human Frzbs in preadipocytes and pancreas". Biochem. Biophys. Res. Commun. 247 (2): 287–93. doi:10.1006/bbrc.1998.8784. PMID 9642118.
Rattner A, Hsieh JC, Smallwood PM, et al. (1997). "A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 2859–63. Bibcode:1997PNAS...94.2859R. doi: 10.1073/pnas.94.7.2859 . PMC 20287 . PMID 9096311.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000120057 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018822 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9391078-5] Melkonyan HS, Chang WC, Shapiro JP, Mahadevappa M, Fitzpatrick PA, Kiefer MC, Tomei LD, Umansky SR (Jan 1998). "SARPs: A family of secreted apoptosis-related proteins". Proc Natl Acad Sci U S A. 94 (25): 13636–41. doi: 10.1073/pnas.94.25.13636 . PMC 28358 . PMID 9391078.

[entrez-6] 1 2 "Entrez Gene: SFRP5 secreted frizzled-related protein 5".

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SFRP5

Related Research Articles

References

Further reading