SFRS11

SRSF11
Identifiers
Aliases	SRSF11 , NET2, SFRS11, dJ677H15.2, p54, serine/arginine-rich splicing factor 11, serine and arginine rich splicing factor 11
External IDs	OMIM: 602010 MGI: 1916457 HomoloGene: 36164 GeneCards: SRSF11
Gene location (Human)
Chr.	Chromosome 1 (human)
End	70,253,052 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	158,036,639 bp
RNA expression pattern
	Top expressed in
	endometrium; ; testicle; ; visceral pleura; ; esophagus; ; parietal pleura; ; sural nerve; ; tibia;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	GO:0001948 protein binding ; nucleic acid binding ; RNA binding ;
Cellular component	nucleus ; nucleoplasm ; nuclear speck ;
Biological process	mRNA splicing, via spliceosome ; termination of RNA polymerase II transcription ; mRNA processing ; mRNA 3'-end processing ; mRNA export from nucleus ; RNA splicing ; RNA export from nucleus ;
	Sources:Amigo / QuickGO
Orthologs
	9295
	69207
	ENSG00000116754
	ENSMUSG00000055436
	Q05519 ; Q5T757
	n/a
NM_001190987 ; NM_004768 ; NM_001350605 ; NM_001350606 ; NM_001350607 ;
	NM_001350608 ; NM_001350609 ; NM_001350610 ; NM_001350611 ; NM_001350612 ; NM_001350613 ; NM_001350614 ; NM_001350615 ; NM_001350616 ; NM_001394402 ; NM_001394403 ; NM_001394404 ; NM_001394405 ; NM_001394406 ; NM_001394407 ; NM_001394408 Contents Interactions ; References ; Further reading ;
	NM_001093752 ; NM_001093753 ; NM_026989 ; NM_001356997
NP_001177916 ; NP_004759 ; NP_001337534 ; NP_001337535 ; NP_001337536 ;
	NP_001337537 ; NP_001337538 ; NP_001337539 ; NP_001337540 ; NP_001337541 ; NP_001337542 ; NP_001337543 ; NP_001337544 ; NP_001337545
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 09, 2022

Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the SFRS11 gene.^[5]^[6]

This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing.^[6]

Interactions

SFRS11 has been shown to interact with U2AF2.^[7]

Related Research Articles

Splicing factor, arginine/serine-rich 2 is a protein that in humans is encoded by the SFRS2 gene.

snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein that in humans is encoded by the SNRNP70 gene. snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming the U1snRNP a core component of the spliceosome. The U1-70K protein and other components of the spliceosome complex form detergent-insoluble aggregates in both sporadic and familial human cases of Alzheimer's disease. U1-70K co-localizes with Tau in neurofibrillary tangles in Alzheimer's disease.

Splicing factor U2AF 35 kDa subunit is a protein that in humans is encoded by the U2AF1 gene.

Transformer-2 protein homolog beta, also known as TRA2B previously known as splicing factor, arginine/serine-rich 10 (SFRS10), is a protein that in humans is encoded by the TRA2B gene.

Serine/arginine-protein kinase SRPK1 is an enzyme that in humans is encoded by the SRPK1 gene.

Pinin is a protein that in humans is encoded by the PNN gene.

Splicing factor, arginine/serine-rich 3 is a protein that in humans is encoded by the SFRS3 gene.

Splicing factor 1 also known as zinc finger protein 162 (ZFM162) is a protein that in humans is encoded by the SF1 gene.

Splicing factor, arginine/serine-rich 6 is a protein that in humans is encoded by the SFRS6 gene.

Splicing factor, arginine/serine-rich 9, also known as SFRS9, is a human gene encoding an SR protein involved in splice site selection in alternative splicing.

Transcription elongation regulator 1, also known as TCERG1, is a protein which in humans is encoded by the TCERG1 gene.

FUS-interacting serine-arginine-rich protein 1 is a protein that in humans is encoded by the SFRS13A gene.

Splicing factor, arginine/serine-rich 4 is a protein that in humans is encoded by the SFRS4 gene.

Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene.

Probable ATP-dependent RNA helicase DDX6 is an enzyme that in humans is encoded by the DDX6 gene.

Serine/threonine-protein kinase PRP4 homolog is an enzyme that in humans is encoded by the PRPF4B gene.

MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MKNK2 gene.

Splicing factor, arginine/serine-rich 12 is a protein that in humans is encoded by the SFRS12 gene.

SFRS2-interacting protein is a protein that in humans is encoded by the SFRS2IP gene.

Serine/arginine-rich splicing factor 1 (SRSF1) also known as alternative splicing factor 1 (ASF1), pre-mRNA-splicing factor SF2 (SF2) or ASF1/SF2 is a protein that in humans is encoded by the SRSF1 gene. ASF/SF2 is an essential sequence specific splicing factor involved in pre-mRNA splicing. SRSF1 is the gene that codes for ASF/SF2 and is found on chromosome 17. The resulting splicing factor is a protein of approximately 33 kDa. ASF/SF2 is necessary for all splicing reactions to occur, and influences splice site selection in a concentration-dependent manner, resulting in alternative splicing. In addition to being involved in the splicing process, ASF/SF2 also mediates post-splicing activities, such as mRNA nuclear export and translation.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000116754 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055436 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Chaudhary N; McMahon C; Blobel G (October 1991). "Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components". Proc Natl Acad Sci U S A. 88 (18): 8189–93. Bibcode:1991PNAS...88.8189C. doi: 10.1073/pnas.88.18.8189 . PMC 52472 . PMID 1896467.
1 2 "Entrez Gene: SFRS11 splicing factor, arginine/serine-rich 11".
↑ Zhang, W J; Wu J Y (October 1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Mol. Cell. Biol. UNITED STATES. 16 (10): 5400–8. doi:10.1128/MCB.16.10.5400. ISSN 0270-7306. PMC 231539 . PMID 8816452.

Zhang WJ; Wu JY (1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Mol. Cell. Biol. 16 (10): 5400–8. doi:10.1128/MCB.16.10.5400. PMC 231539 . PMID 8816452.
Straub T, Grue P, Uhse A, et al. (1998). "The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction". J. Biol. Chem. 273 (41): 26261–4. doi: 10.1074/jbc.273.41.26261 . PMID 9756848.
Page-McCaw PS; Amonlirdviman K; Sharp PA (2000). "PUF60: a novel U2AF65-related splicing activity". RNA. 5 (12): 1548–60. doi:10.1017/S1355838299991938. PMC 1369877 . PMID 10606266.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Sakashita E, Tatsumi S, Werner D, et al. (2004). "Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo". Mol. Cell. Biol. 24 (3): 1174–87. doi:10.1128/MCB.24.3.1174-1187.2004. PMC 321435 . PMID 14729963.
Wu JY, Kar A, Kuo D, et al. (2006). "SRp54 (SFRS11), a regulator for tau exon 10 alternative splicing identified by an expression cloning strategy". Mol. Cell. Biol. 26 (18): 6739–47. doi:10.1128/MCB.00739-06. PMC 1592875 . PMID 16943417.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000116754 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055436 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1896467-5] Chaudhary N; McMahon C; Blobel G (October 1991). "Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components". Proc Natl Acad Sci U S A. 88 (18): 8189–93. Bibcode:1991PNAS...88.8189C. doi: 10.1073/pnas.88.18.8189 . PMC 52472 . PMID 1896467.

[entrez-6] 1 2 "Entrez Gene: SFRS11 splicing factor, arginine/serine-rich 11".

[pmid8816452-7] Zhang, W J; Wu J Y (October 1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Mol. Cell. Biol. UNITED STATES. 16 (10): 5400–8. doi:10.1128/MCB.16.10.5400. ISSN 0270-7306. PMC 231539 . PMID 8816452.

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SFRS11

Contents

Interactions

Related Research Articles

References

Further reading