SFRS11

SRSF11
Identifiers
Aliases	SRSF11 , NET2, SFRS11, dJ677H15.2, p54, serine/arginine-rich splicing factor 11, serine and arginine rich splicing factor 11
External IDs	OMIM: 602010; MGI: 1916457; HomoloGene: 36164; GeneCards: SRSF11; OMA:SRSF11 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p31.1 Start 70,205,682 bp [1] End 70,253,052 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 H4 Start 158,010,473 bp [2] End 158,036,639 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in visceral pleura parietal pleura tibia mucosa of paranasal sinus gastric mucosa Achilles tendon endothelial cell skin of hip sural nerve germinal epithelium Top expressed in neural layer of retina tail of embryo genital tubercle abdominal wall cerebellar cortex saccule primitive streak dermis vas deferens superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nucleic acid binding RNA binding Cellular component nucleus nucleoplasm nuclear speck Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA processing mRNA 3'-end processing mRNA export from nucleus RNA splicing RNA export from nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9295 69207 Ensembl ENSG00000116754 ENSMUSG00000055436 UniProt Q05519 Q5T757 n/a RefSeq (mRNA) NM_001190987 NM_004768 NM_001350605 NM_001350606 NM_001350607 NM_001350608 NM_001350609 NM_001350610 NM_001350611 NM_001350612 NM_001350613 NM_001350614 NM_001350615 NM_001350616 NM_001394402 NM_001394403 NM_001394404 NM_001394405 NM_001394406 NM_001394407 NM_001394408 NM_001093752 NM_001093753 NM_026989 NM_001356997 RefSeq (protein) NP_001177916 NP_004759 NP_001337534 NP_001337535 NP_001337536 NP_001337537 NP_001337538 NP_001337539 NP_001337540 NP_001337541 NP_001337542 NP_001337543 NP_001337544 NP_001337545 n/a Location (UCSC) Chr 1: 70.21 – 70.25 Mb Chr 3: 158.01 – 158.04 Mb PubMed search [3] [4]
Wikidata
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Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the SFRS11 gene. ^{[5] [6]}

This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. ^[6]

Interactions

SFRS11 has been shown to interact with U2AF2. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000116754 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055436 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chaudhary N; McMahon C; Blobel G (October 1991). "Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components". Proc Natl Acad Sci U S A. 88 (18): 8189–93. Bibcode:1991PNAS...88.8189C. doi: 10.1073/pnas.88.18.8189 . PMC   52472 . PMID   1896467.
6. "Entrez Gene: SFRS11 splicing factor, arginine/serine-rich 11".
7. Zhang, W J; Wu J Y (October 1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Mol. Cell. Biol. 16 (10). UNITED STATES: 5400–8. doi:10.1128/MCB.16.10.5400. ISSN   0270-7306. PMC   231539 . PMID   8816452.

Further reading

• Zhang WJ; Wu JY (1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Mol. Cell. Biol. 16 (10): 5400–8. doi:10.1128/MCB.16.10.5400. PMC   231539 . PMID   8816452.
• Straub T, Grue P, Uhse A, et al. (1998). "The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction". J. Biol. Chem. 273 (41): 26261–4. doi: 10.1074/jbc.273.41.26261 . PMID   9756848.
• Page-McCaw PS; Amonlirdviman K; Sharp PA (2000). "PUF60: a novel U2AF65-related splicing activity". RNA. 5 (12): 1548–60. doi:10.1017/S1355838299991938. PMC   1369877 . PMID   10606266.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Sakashita E, Tatsumi S, Werner D, et al. (2004). "Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo". Mol. Cell. Biol. 24 (3): 1174–87. doi:10.1128/MCB.24.3.1174-1187.2004. PMC   321435 . PMID   14729963.
• Wu JY, Kar A, Kuo D, et al. (2006). "SRp54 (SFRS11), a regulator for tau exon 10 alternative splicing identified by an expression cloning strategy". Mol. Cell. Biol. 26 (18): 6739–47. doi:10.1128/MCB.00739-06. PMC   1592875 . PMID   16943417.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.