SFRS4

SRSF4
Identifiers
Aliases	SRSF4 , SFRS4, SRP75, serine/arginine-rich splicing factor 4, serine and arginine rich splicing factor 4
External IDs	OMIM: 601940; MGI: 1890577; HomoloGene: 25624; GeneCards: SRSF4; OMA:SRSF4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p35.3 Start 29,147,743 bp [1] End 29,181,900 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 D2.3 Start 131,873,617 bp [2] End 131,901,706 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve middle frontal gyrus paraflocculus of cerebellum ventricular zone body of uterus canal of the cervix gastric mucosa muscle layer of sigmoid colon left ovary right ovary Top expressed in neural layer of retina ventricular zone ascending aorta aortic valve primitive streak ganglionic eminence somite mandibular prominence maxillary prominence retinal pigment epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific mRNA binding nucleic acid binding protein binding RNA binding nucleotide binding Cellular component nucleus nucleoplasm nuclear speck Biological process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA processing negative regulation of mRNA splicing, via spliceosome mRNA 3'-end processing mRNA export from nucleus RNA splicing RNA export from nucleus response to insulin regulation of alternative mRNA splicing, via spliceosome mRNA cis splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6429 57317 Ensembl ENSG00000116350 ENSMUSG00000028911 UniProt Q08170 Q8VE97 RefSeq (mRNA) NM_005626 NM_020587 RefSeq (protein) NP_005617 n/a Location (UCSC) Chr 1: 29.15 – 29.18 Mb Chr 4: 131.87 – 131.9 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Splicing factor, arginine/serine-rich 4 is a protein that in humans is encoded by the SFRS4 gene. ^{[5] [6]}

Interactions

SFRS4 has been shown to interact with Pinin. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000116350 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028911 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zahler AM; Neugebauer KM; Stolk JA; Roth MB (Jul 1993). "Human SR proteins and isolation of a cDNA encoding SRp75". Mol Cell Biol. 13 (7): 4023–8. doi:10.1128/MCB.13.7.4023. PMC   359951 . PMID   8321209.
6. "Entrez Gene: SFRS4 splicing factor, arginine/serine-rich 4".
7. Zimowska, Grazyna; Shi Jia; Munguba Gustavo; Jackson Moira R; Alpatov Roman; Simmons Matthew N; Shi Yujiang; Sugrue Stephen P (Nov 2003). "Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells". Invest. Ophthalmol. Vis. Sci. 44 (11): 4715–23. doi: 10.1167/iovs.03-0240 . ISSN   0146-0404. PMID   14578391.

Further reading

• Zahler AM; Lane WS; Stolk JA; Roth MB (1992). "SR proteins: a conserved family of pre-mRNA splicing factors". Genes Dev. 6 (5): 837–47. doi: 10.1101/gad.6.5.837 . PMID   1577277.
• Ramchatesingh J, Zahler AM, Neugebauer KM, et al. (1995). "A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer". Mol. Cell. Biol. 15 (9): 4898–907. doi:10.1128/MCB.15.9.4898. PMC   230736 . PMID   7651409.
• Maruyama K; Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Gui JF; Lane WS; Fu XD (1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. Bibcode:1994Natur.369..678G. doi:10.1038/369678a0. PMID   8208298. S2CID   4275539. Archived from the original on 2020-12-03. Retrieved 2019-12-12.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Zhang WJ; Wu JY (1998). "Sip1, a Novel RS Domain-Containing Protein Essential for Pre-mRNA Splicing". Mol. Cell. Biol. 18 (2): 676–84. doi:10.1128/MCB.18.2.676. PMC   108778 . PMID   9447963.
• Blencowe BJ; Issner R; Nickerson JA; Sharp PA (1998). "A coactivator of pre-mRNA splicing". Genes Dev. 12 (7): 996–1009. doi:10.1101/gad.12.7.996. PMC   316672 . PMID   9531537.
• Papoutsopoulou S, Nikolakaki E, Chalepakis G, et al. (1999). "SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1". Nucleic Acids Res. 27 (14): 2972–80. doi:10.1093/nar/27.14.2972. PMC   148514 . PMID   10390541.
• Monsalve M, Wu Z, Adelmant G, et al. (2000). "Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1". Mol. Cell. 6 (2): 307–16. doi: 10.1016/S1097-2765(00)00031-9 . PMID   10983978.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Meissner M, Lopato S, Gotzmann J, et al. (2003). "Proto-oncoprotein TLS/FUS is associated to the nuclear matrix and complexed with splicing factors PTB, SRm160, and SR proteins". Exp. Cell Res. 283 (2): 184–95. doi:10.1016/S0014-4827(02)00046-0. PMID   12581738.
• Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of Alternative Splicing by SRrp86 and Its Interacting Proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC   207616 . PMID   14559993.
• Zimowska G, Shi J, Munguba G, et al. (2003). "Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells". Invest. Ophthalmol. Vis. Sci. 44 (11): 4715–23. doi: 10.1167/iovs.03-0240 . PMID   14578391.
• de Graaf K, Hekerman P, Spelten O, et al. (2004). "Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors". J. Biol. Chem. 279 (6): 4612–24. doi: 10.1074/jbc.M310794200 . PMID   14623875.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID   15761153. S2CID   39457788.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.