SFRS4

SRSF4
Identifiers
Aliases	SRSF4 , SFRS4, SRP75, serine/arginine-rich splicing factor 4, serine and arginine rich splicing factor 4
External IDs	OMIM: 601940 MGI: 1890577 HomoloGene: 25624 GeneCards: SRSF4
Gene location (Human)
Chr.	Chromosome 1 (human)
End	29,181,900 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	131,901,706 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; middle frontal gyrus; ; canal of the cervix; ; gastric mucosa; ; right lung; ; left lobe of thyroid gland; ; left uterine tube; ; ganglionic eminence; ; right lobe of thyroid gland; ; upper lobe of left lung;
	Top expressed in
	ascending aorta; ; aortic valve; ; primitive streak; ; ganglionic eminence; ; somite; ; maxillary prominence; ; retinal pigment epithelium; ; ureter; ; hair follicle; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific mRNA binding ; nucleic acid binding ; protein binding ; RNA binding ; nucleotide binding ;
Cellular component	nucleus ; nucleoplasm ; nuclear speck ;
Biological process	RNA splicing, via transesterification reactions ; mRNA splicing, via spliceosome ; termination of RNA polymerase II transcription ; mRNA processing ; negative regulation of mRNA splicing, via spliceosome ; mRNA 3'-end processing ; mRNA export from nucleus ; RNA splicing ; RNA export from nucleus ; response to insulin ; regulation of alternative mRNA splicing, via spliceosome ; mRNA cis splicing, via spliceosome ;
	Sources:Amigo / QuickGO
Orthologs
	6429
	57317
	ENSG00000116350
	ENSMUSG00000028911
	Q08170
	Q8VE97
	NM_005626
	NM_020587
	NP_005617
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 11, 2022

Splicing factor, arginine/serine-rich 4 is a protein that in humans is encoded by the SFRS4 gene.^[5]^[6]

Interactions

SFRS4 has been shown to interact with Pinin.^[7]

Related Research Articles

Splicing factor, arginine/serine-rich 2 is a protein that in humans is encoded by the SFRS2 gene. MDS-associated splicing factor SRSF2 affects the expression of Class III and Class IV isoforms and perturbs granulopoiesis and SRSF2 P95H promotes Class IV splicing by binding to key ESE sequences in CSF3R exon 17, and that SRSF2, when mutated, contributes to dysgranulopoiesis.

Transformer-2 protein homolog beta, also known as TRA2B previously known as splicing factor, arginine/serine-rich 10 (SFRS10), is a protein that in humans is encoded by the TRA2B gene.

Pinin is a protein that in humans is encoded by the PNN gene.

Splicing factor, arginine/serine-rich 3 is a protein that in humans is encoded by the SFRS3 gene.

Splicing factor, arginine/serine-rich 6 is a protein that in humans is encoded by the SFRS6 gene.

Splicing factor 3A subunit 3 is a protein that in humans is encoded by the SF3A3 gene.

MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene.

Splicing factor, arginine/serine-rich 9, also known as SFRS9, is a human gene encoding an SR protein involved in splice site selection in alternative splicing.

Splicing factor, arginine/serine-rich 5 is a protein that in humans is encoded by the SFRS5 gene.

Transcription elongation regulator 1, also known as TCERG1, is a protein which in humans is encoded by the TCERG1 gene.

Dual specificity protein kinase CLK1 is an enzyme that in humans is encoded by the CLK1 gene.

FUS-interacting serine-arginine-rich protein 1 is a protein that in humans is encoded by the SFRS13A gene.

Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene.

Serine/arginine repetitive matrix protein 2 is a protein that in humans is encoded by the SRRM2 gene.

Serine/threonine-protein kinase PRP4 homolog is an enzyme that in humans is encoded by the PRPF4B gene.

MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MKNK2 gene.

Splicing factor, arginine/serine-rich 12 is a protein that in humans is encoded by the SFRS12 gene.

SFRS2-interacting protein is a protein that in humans is encoded by the SFRS2IP gene.

Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the SFRS11 gene.

Splicing factor, arginine/serine-rich 18 is a protein that in humans is encoded by the SFRS18 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000116350 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028911 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zahler AM; Neugebauer KM; Stolk JA; Roth MB (Jul 1993). "Human SR proteins and isolation of a cDNA encoding SRp75". Mol Cell Biol. 13 (7): 4023–8. doi:10.1128/MCB.13.7.4023. PMC 359951 . PMID 8321209.
↑ "Entrez Gene: SFRS4 splicing factor, arginine/serine-rich 4".
↑ Zimowska, Grazyna; Shi Jia; Munguba Gustavo; Jackson Moira R; Alpatov Roman; Simmons Matthew N; Shi Yujiang; Sugrue Stephen P (Nov 2003). "Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells". Invest. Ophthalmol. Vis. Sci. 44 (11): 4715–23. doi: 10.1167/iovs.03-0240 . ISSN 0146-0404. PMID 14578391.

Zahler AM; Lane WS; Stolk JA; Roth MB (1992). "SR proteins: a conserved family of pre-mRNA splicing factors". Genes Dev. 6 (5): 837–47. doi: 10.1101/gad.6.5.837 . PMID 1577277.
Ramchatesingh J, Zahler AM, Neugebauer KM, et al. (1995). "A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer". Mol. Cell. Biol. 15 (9): 4898–907. doi:10.1128/MCB.15.9.4898. PMC 230736 . PMID 7651409.
Maruyama K; Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Gui JF; Lane WS; Fu XD (1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. Bibcode:1994Natur.369..678G. doi:10.1038/369678a0. PMID 8208298. S2CID 4275539. Archived from the original on 2020-12-03. Retrieved 2019-12-12.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Zhang WJ; Wu JY (1998). "Sip1, a Novel RS Domain-Containing Protein Essential for Pre-mRNA Splicing". Mol. Cell. Biol. 18 (2): 676–84. doi:10.1128/MCB.18.2.676. PMC 108778 . PMID 9447963.
Blencowe BJ; Issner R; Nickerson JA; Sharp PA (1998). "A coactivator of pre-mRNA splicing". Genes Dev. 12 (7): 996–1009. doi:10.1101/gad.12.7.996. PMC 316672 . PMID 9531537.
Papoutsopoulou S, Nikolakaki E, Chalepakis G, et al. (1999). "SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1". Nucleic Acids Res. 27 (14): 2972–80. doi:10.1093/nar/27.14.2972. PMC 148514 . PMID 10390541.
Monsalve M, Wu Z, Adelmant G, et al. (2000). "Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1". Mol. Cell. 6 (2): 307–16. doi: 10.1016/S1097-2765(00)00031-9 . PMID 10983978.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Meissner M, Lopato S, Gotzmann J, et al. (2003). "Proto-oncoprotein TLS/FUS is associated to the nuclear matrix and complexed with splicing factors PTB, SRm160, and SR proteins". Exp. Cell Res. 283 (2): 184–95. doi:10.1016/S0014-4827(02)00046-0. PMID 12581738.
Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of Alternative Splicing by SRrp86 and Its Interacting Proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616 . PMID 14559993.
Zimowska G, Shi J, Munguba G, et al. (2003). "Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells". Invest. Ophthalmol. Vis. Sci. 44 (11): 4715–23. doi: 10.1167/iovs.03-0240 . PMID 14578391.
de Graaf K, Hekerman P, Spelten O, et al. (2004). "Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors". J. Biol. Chem. 279 (6): 4612–24. doi: 10.1074/jbc.M310794200 . PMID 14623875.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID 16710414.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000116350 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028911 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8321209-5] Zahler AM; Neugebauer KM; Stolk JA; Roth MB (Jul 1993). "Human SR proteins and isolation of a cDNA encoding SRp75". Mol Cell Biol. 13 (7): 4023–8. doi:10.1128/MCB.13.7.4023. PMC 359951 . PMID 8321209.

[entrez-6] "Entrez Gene: SFRS4 splicing factor, arginine/serine-rich 4".

[pmid14578391-7] Zimowska, Grazyna; Shi Jia; Munguba Gustavo; Jackson Moira R; Alpatov Roman; Simmons Matthew N; Shi Yujiang; Sugrue Stephen P (Nov 2003). "Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells". Invest. Ophthalmol. Vis. Sci. 44 (11): 4715–23. doi: 10.1167/iovs.03-0240 . ISSN 0146-0404. PMID 14578391.

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SFRS4

Contents

Interactions

Related Research Articles

References

Further reading