SGPP1

SGPP1
Identifiers
Aliases	SGPP1 , SPPase1, sphingosine-1-phosphate phosphatase 1, SPP-1
External IDs	OMIM: 612826 MGI: 2135760 HomoloGene: 101696 GeneCards: SGPP1
Gene location (Human)
Chr.	Chromosome 14 (human)
End	63,728,065 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	75,735,729 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• hydrolase activity ; • sphingosine-1-phosphate phosphatase activity ; • dihydrosphingosine-1-phosphate phosphatase activity ;
Cellular component	• integral component of membrane ; • endoplasmic reticulum membrane ; • endoplasmic reticulum ; • membrane ; • plasma membrane ; • nucleus ; • nucleoplasm ;
Biological process	• intrinsic apoptotic signaling pathway ; • sphingosine metabolic process ; • sphingolipid biosynthetic process ; • extrinsic apoptotic signaling pathway ; • dephosphorylation ; • sphinganine-1-phosphate metabolic process ; • sphingolipid metabolic process ; • ER to Golgi ceramide transport ; • regulation of keratinocyte differentiation ; • regulation of epidermis development ;
	Sources:Amigo / QuickGO
Orthologs
	81537
	81535
	ENSG00000126821 ; ENSG00000285281
	ENSMUSG00000021054
	Q9BX95
	Q9JI99
	NM_030791
	NM_030750
	NP_110418
	NP_109675
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 07, 2021

Sphingosine-1-phosphate phosphatase 1 is an enzyme that in humans is encoded by the SGPP1 gene.^[5]^[6]

Related Research Articles

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References

1 2 3 ENSG00000285281 GRCh38: Ensembl release 89: ENSG00000126821, ENSG00000285281 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021054 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mandala SM, Thornton R, Galve-Roperh I, Poulton S, Peterson C, Olivera A, Bergstrom J, Kurtz MB, Spiegel S (Aug 2000). "Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death". Proc Natl Acad Sci U S A. 97 (14): 7859–64. doi:10.1073/pnas.120146897. PMC 16635 . PMID 10859351.
↑ "Entrez Gene: SGPP1 sphingosine-1-phosphate phosphatase 1".

Ogawa C, Kihara A, Gokoh M, Igarashi Y (2003). "Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2". J. Biol. Chem. 278 (2): 1268–72. doi: 10.1074/jbc.M209514200 . PMID 12411432.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 . PMID 12477932.
Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. doi: 10.1038/nature01348 . PMID 12508121.
Johnson KR, Johnson KY, Becker KP, et al. (2003). "Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability". J. Biol. Chem. 278 (36): 34541–7. doi: 10.1074/jbc.M301741200 . PMID 12815058.
Le Stunff H, Mikami A, Giussani P, et al. (2004). "Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis". J. Biol. Chem. 279 (33): 34290–7. doi: 10.1074/jbc.M404907200 . PMID 15180992.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Giussani P, Maceyka M, Le Stunff H, et al. (2006). "Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide". Mol. Cell. Biol. 26 (13): 5055–69. doi:10.1128/MCB.02107-05. PMC 1489178 . PMID 16782891.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000285281 GRCh38: Ensembl release 89: ENSG00000126821, ENSG00000285281 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021054 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10859351-5] Mandala SM, Thornton R, Galve-Roperh I, Poulton S, Peterson C, Olivera A, Bergstrom J, Kurtz MB, Spiegel S (Aug 2000). "Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death". Proc Natl Acad Sci U S A. 97 (14): 7859–64. doi:10.1073/pnas.120146897. PMC 16635 . PMID 10859351.

[entrez-6] "Entrez Gene: SGPP1 sphingosine-1-phosphate phosphatase 1".

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SGPP1

Related Research Articles

References

Further reading