SGSM1

SGSM1
Identifiers
Aliases	SGSM1 , RUTBC2, small G protein signaling modulator 1
External IDs	OMIM: 611417 MGI: 107320 HomoloGene: 64485 GeneCards: SGSM1
Gene location (Human)
Chr.	Chromosome 22 (human)
End	24,927,578 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	113,458,652 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; superior frontal gyrus; ; postcentral gyrus; ; entorhinal cortex; ; hypothalamus; ; cerebellar hemisphere; ; pancreatic ductal cell; ; nucleus accumbens; ; prefrontal cortex;
	Top expressed in
	superior cervical ganglion; ; arcuate nucleus; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus; ; median eminence; ; ventromedial nucleus; ; lateral hypothalamus; ; suprachiasmatic nucleus; ; visual cortex; ; piriform cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; GTPase activator activity ;
Cellular component	Golgi apparatus ; membrane ; cytoplasm ; cytoplasmic vesicle membrane ; cytosol ; endomembrane system ; cytoplasmic vesicle ;
Biological process	activation of GTPase activity ; intracellular protein transport ; regulation of vesicle fusion ;
	Sources:Amigo / QuickGO
Orthologs
	129049
	52850
	ENSG00000167037
	ENSMUSG00000042216
	Q2NKQ1
	Q8BPQ7
	NM_133454 ; NM_001039948 ; NM_001098497 ; NM_001098498
	NM_001162965 ; NM_001254731 ; NM_172718 ; NM_001309526 ; NM_001309528
	NP_001035037 ; NP_001091967 ; NP_001091968 ; NP_597711
	NP_001156437 ; NP_001241660 ; NP_001296455 ; NP_001296457 ; NP_766306
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 05, 2023

Small G protein signaling modulator 1 (SGSM1) also known as RUN and TBC1 domain-containing protein 2 (RUTBC2) and nurr1-interacting protein (NuIP)^[5] is a protein in humans that is encoded by the SGSM1 gene.^[6]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000167037 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042216 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Luo Y, Xing F, Guiliano R, Federoff HJ (September 2008). "Identification of a novel nurr1-interacting protein". The Journal of Neuroscience. 28 (37): 9277–86. doi: 10.1523/JNEUROSCI.3021-08.2008 . PMC 6670918 . PMID 18784308.
↑ "Entrez Gene: Small G protein signaling modulator 1".
↑ Yang H, Sasaki T, Minoshima S, Shimizu N (August 2007). "Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway". Genomics. 90 (2): 249–60. doi: 10.1016/j.ygeno.2007.03.013 . PMID 17509819.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000167037 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042216 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid18784308-5] Luo Y, Xing F, Guiliano R, Federoff HJ (September 2008). "Identification of a novel nurr1-interacting protein". The Journal of Neuroscience. 28 (37): 9277–86. doi: 10.1523/JNEUROSCI.3021-08.2008 . PMC 6670918 . PMID 18784308.

[entrez-6] "Entrez Gene: Small G protein signaling modulator 1".

[Yang_2007-7] Yang H, Sasaki T, Minoshima S, Shimizu N (August 2007). "Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway". Genomics. 90 (2): 249–60. doi: 10.1016/j.ygeno.2007.03.013 . PMID 17509819.

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