SH2D3A

SH2D3A
Identifiers
Aliases	SH2D3A , NSP1, SH2 domain containing 3A
External IDs	OMIM: 604721; HomoloGene: 48351; GeneCards: SH2D3A; OMA:SH2D3A - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.3 Start 6,752,160 bp [1] End 6,767,463 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell olfactory bulb mucosa of transverse colon skin of abdomen skin of leg granulocyte olfactory zone of nasal mucosa minor salivary glands body of pancreas tendon of biceps brachii n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding guanyl-nucleotide exchange factor activity Cellular component intracellular anatomical structure Biological process small GTPase mediated signal transduction JNK cascade positive regulation of signal transduction positive regulation of peptidyl-serine phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10045 n/a Ensembl ENSG00000125731 n/a UniProt Q9BRG2 n/a RefSeq (mRNA) NM_005490 n/a RefSeq (protein) NP_005481 n/a Location (UCSC) Chr 19: 6.75 – 6.77 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

SH2 domain-containing protein 3A is a protein that in humans is encoded by the SH2D3A gene. ^{[3] [4]} The protein may be useful in Western Blots and ELISAs. ^[5]

Interactions

SH2D3A has been shown to interact with the epidermal growth factor receptor. ^[3] The gene may play a role in JNK activation. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000125731 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Lu Y, Brush J, Stewart TA (Apr 1999). "NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway". The Journal of Biological Chemistry. 274 (15): 10047–52. doi: 10.1074/jbc.274.15.10047 . PMID   10187783.
4. "Entrez Gene: SH2D3A SH2 domain containing 3A".
5. "Recombinant Human SH2D3A Protein". potassium-channel. Potassium Channel. 1 August 2017. Retrieved 18 September 2017.
6. "SH2D3A Gene". genecards.org. Gene Cards. Retrieved 18 September 2017.

Further reading

• Near RI, Zhang Y, Makkinje A, Vanden Borre P, Lerner A (Sep 2007). "AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology". Journal of Cellular Physiology. 212 (3): 655–65. doi:10.1002/jcp.21059. PMC   2640322 . PMID   17427198.
• Vervoort VS, Roselli S, Oshima RG, Pasquale EB (Apr 2007). "Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling". Gene. 391 (1–2): 161–70. doi:10.1016/j.gene.2006.12.016. PMC   1876674 . PMID   17270363.
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (Jun 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–95. doi: 10.1074/mcp.M500021-MCP200 . PMID   15778465.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.

External links

• SH2D3A human gene location in the UCSC Genome Browser .
• SH2D3A human gene details in the UCSC Genome Browser .