SH2D4A

SH2D4A
Identifiers
Aliases	SH2D4A , PPP1R38, SH2A, SH2 domain containing 4A
External IDs	OMIM: 614968; MGI: 1919531; HomoloGene: 11117; GeneCards: SH2D4A; OMA:SH2D4A - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8p21.3 Start 19,313,693 bp [1] End 19,396,218 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 B3.3 Start 68,729,219 bp [2] End 68,800,351 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Achilles tendon amniotic fluid buccal mucosa cell palpebral conjunctiva left ovary testicle pylorus parotid gland right lobe of liver Top expressed in epithelium of stomach parotid gland left colon urothelium left lung lobe transitional epithelium of urinary bladder skin of external ear esophagus medullary collecting duct right lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding phosphatase binding Cellular component cytoplasm cytosol Biological process negative regulation of phosphatase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 63898 72281 Ensembl ENSG00000104611 ENSMUSG00000053886 UniProt Q9H788 Q9D7V1 RefSeq (mRNA) NM_001174159 NM_001174160 NM_022071 NM_001363110 NM_001363111 NM_028182 RefSeq (protein) NP_001167630 NP_001167631 NP_071354 NP_001350039 NP_001350040 NP_082458 Location (UCSC) Chr 8: 19.31 – 19.4 Mb Chr 8: 68.73 – 68.8 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SH2 domain-containing protein 4A is a protein that in humans is encoded by the SH2D4A gene. ^[5]

Interactions

SH2D4A has been shown to interact with MAGEA11. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000104611 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053886 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SH2D4A SH2 domain containing 4A".
6. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Dai S, Zhao Y, Ding Q (2003). "[A novel member of SH(2) signaling protein family: cloning and characterization of SH(2)A gene]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 19 (6): 458–462. PMID   12476414.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID   14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.