SH2D4A

SH2D4A
Identifiers
Aliases	SH2D4A , PPP1R38, SH2A, SH2 domain containing 4A
External IDs	OMIM: 614968 MGI: 1919531 HomoloGene: 11117 GeneCards: SH2D4A
Gene location (Human)
Chr.	Chromosome 8 (human)
End	19,396,218 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	68,800,351 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; Achilles tendon; ; amniotic fluid; ; palpebral conjunctiva; ; pylorus; ; parotid gland; ; right lobe of liver; ; pancreatic epithelial cell; ; cardia; ; vena cava;
	Top expressed in
	Epithelium of stomach; ; parotid gland; ; left colon; ; urothelium; ; left lung lobe; ; esophagus; ; medullary collecting duct; ; right lung lobe; ; duodenum; ; conjunctival fornix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; phosphatase binding ;
Cellular component	cytoplasm ; cytosol ;
Biological process	negative regulation of phosphatase activity ;
	Sources:Amigo / QuickGO
Orthologs
	63898
	72281
	ENSG00000104611
	ENSMUSG00000053886
	Q9H788
	Q9D7V1
	NM_001174159 ; NM_001174160 ; NM_022071 ; NM_001363110 ; NM_001363111 Contents Interactions ; References ; Further reading ;
	NM_028182
	NP_001167630 ; NP_001167631 ; NP_071354 ; NP_001350039 ; NP_001350040
	NP_082458
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

SH2 domain-containing protein 4A is a protein that in humans is encoded by the SH2D4A gene.^[5]

Interactions

SH2D4A has been shown to interact with MAGEA11.^[6]

Related Research Articles

Cyclin dependent kinase 13 is an enzyme that in humans is encoded by the CDK13 gene.

NSFL1 cofactor p47 is a protein that in humans is encoded by the NSFL1C gene.

Cytoplasmic dynein 1 intermediate chain 2 is a protein that in humans is encoded by the DYNC1I2 gene.

Nuclear receptor-binding protein is a protein that in humans is encoded by the NRBP1 gene.

Osteoclast-stimulating factor 1 is a protein that in humans is encoded by the OSTF1 gene.

G2 and S phase-expressed protein 1 is an enzyme that in humans is encoded by the GTSE1 gene.

Ubiquitin carboxyl-terminal hydrolase 16 is an enzyme that in humans is encoded by the USP16 gene.

WW domain-containing adapter protein with coiled-coil is a protein that in humans is encoded by the WAC gene.

HAUS augmin like complex subunit 6, also known as HAUS6, is a human gene.

Zinc finger protein 655 is a protein that in humans is encoded by the ZNF655 gene.

Periodic tryptophan protein 1 homolog is a protein that in humans is encoded by the PWP1 gene.

ATPase WRNIP1 is an enzyme that in humans is encoded by the WRNIP1 gene. The protein is a member of AAA ATPase family.

Exportin-6 is a protein that in humans is encoded by the XPO6 gene.

Glutaredoxin-3 is a protein that in humans is encoded by the GLRX3 gene.

Putative rRNA methyltransferase 3 is an enzyme that in humans is encoded by the FTSJ3 gene.

Zinc finger protein 330 is a protein that in humans is encoded by the ZNF330 gene.

Glutamine-dependent NAD(+) synthetase is an enzyme that in humans is encoded by the NADSYN1 gene.

Spermatogenesis-defective protein 39 homolog is a protein that in humans is encoded by the VIPAS39 gene. This protein is involved in the sorting of lysosomal proteins. Mutations in this gene are associated with ARCS2. Alternative splicing results in multiple transcript variants.

Uridine-cytidine kinase-like 1 is an enzyme that in humans is encoded by the UCKL1 gene.

Centrosomal protein of 70 kDa is a protein that in humans is encoded by the CEP70 gene. The protein interacts with γ-tubulin through its coiled coil domains to localize at the centrosome. CEP70 is involved in organizing microtubules in interphase cells and is required for proper organization and orientation of the mitotic spindle.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000104611 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053886 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: SH2D4A SH2 domain containing 4A".
↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Dai S, Zhao Y, Ding Q (2003). "[A novel member of SH(2) signaling protein family: cloning and characterization of SH(2)A gene]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 19 (6): 458–462. PMID 12476414.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000104611 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053886 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SH2D4A SH2 domain containing 4A".

[pmid16189514-6] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[1]

[2]

[3]

[4]

[5]

[6]

SH2D4A

Contents

Interactions

Related Research Articles

References

Further reading