SH3BP4

SH3BP4
Identifiers
Aliases	SH3BP4 , BOG25, TTP, SH3 domain binding protein 4
External IDs	OMIM: 605611 MGI: 2138297 HomoloGene: 8726 GeneCards: SH3BP4
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q37.2 Start 234,952,017 bp [1] End 235,055,714 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 D Start 88,998,137 bp [2] End 89,082,790 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland trachea renal medulla germinal epithelium caput epididymis tibia lactiferous duct minor salivary gland bronchial epithelial cell stromal cell of endometrium Top expressed in lacrimal gland molar parotid gland maxillary prominence seminal vesicula ascending aorta somite optic nerve right lung atrium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding GDP-dissociation inhibitor activity Cellular component cytoplasm membrane clathrin-coated pit cytoplasmic vesicle extracellular exosome nucleus clathrin-coated vesicle Biological process cellular response to amino acid stimulus protein localization to lysosome negative regulation of GTPase activity regulation of catalytic activity endocytosis negative regulation of cell growth positive regulation of autophagy amino acid import negative regulation of cell population proliferation negative regulation of TOR signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23677 98402 Ensembl ENSG00000130147 ENSMUSG00000036206 UniProt Q9P0V3 Q921I6 RefSeq (mRNA) NM_014521 NM_133816 RefSeq (protein) NP_055336 NP_001358231 NP_001358232 NP_001358233 NP_001358234 NP_001358235 NP_598577 Location (UCSC) Chr 2: 234.95 – 235.06 Mb Chr 1: 89 – 89.08 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SH3 domain-binding protein 4 is a protein that in humans is encoded by the SH3BP4 gene. ^{[5] [6]}

This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000130147 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036206 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dunlevy JR, Berryhill BL, Vergnes JP, SundarRaj N, Hassell JR (Mar 2000). "Cloning, chromosomal localization, and characterization of cDNA from a novel gene, SH3BP4, expressed by human corneal fibroblasts". Genomics. 62 (3): 519–24. doi:10.1006/geno.1999.5994. PMID   10644451.
6. "Entrez Gene: SH3BP4 SH3-domain binding protein 4".

Further reading

• Wong WT, Schumacher C, Salcini AE, et al. (1995). "A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9530–4. Bibcode:1995PNAS...92.9530W. doi: 10.1073/pnas.92.21.9530 . PMC   40835 . PMID   7568168.
• Salcini AE, Confalonieri S, Doria M, et al. (1997). "Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module". Genes Dev. 11 (17): 2239–49. doi:10.1101/gad.11.17.2239. PMC   275390 . PMID   9303539.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi: 10.1016/j.cub.2004.07.051 . PMID   15324660. S2CID   2371325.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Khanobdee K, Kolberg JB, Dunlevy JR (2005). "Nuclear and plasma membrane localization of SH3BP4 in retinal pigment epithelial cells". Mol. Vis. 10: 933–42. PMID   15616480.
• Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi: 10.1074/mcp.M500021-MCP200 . PMID   15778465.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.
• Tosoni D, Puri C, Confalonieri S, et al. (2006). "TTP specifically regulates the internalization of the transferrin receptor". Cell. 123 (5): 875–88. doi: 10.1016/j.cell.2005.10.021 . PMID   16325581. S2CID   5809800.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.