SH3GL2

SH3GL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X03, 1X04, 2D4C, 2DBM
Identifiers
Aliases	SH3GL2 , CNSA2, EEN-B1, SH3D2A, SH3P4, SH3 domain containing GRB2 like 2, endophilin A1
External IDs	OMIM: 604465 MGI: 700009 HomoloGene: 20652 GeneCards: SH3GL2
Gene location (Human)
Chr.	Chromosome 9 (human)
End	17,797,124 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	85,557,432 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; endothelial cell; ; cerebellar cortex; ; cerebellar hemisphere; ; cerebellar vermis; ; orbitofrontal cortex; ; superior frontal gyrus; ; Brodmann area 9; ; prefrontal cortex;
	Top expressed in
	cerebellar vermis; ; pontine nuclei; ; subiculum; ; habenula; ; medial vestibular nucleus; ; motor neuron; ; medial dorsal nucleus; ; medial geniculate nucleus; ; prefrontal cortex; ; anterior horn of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; lipid binding ; identical protein binding ; protein homodimerization activity ; protein C-terminus binding ; protein kinase binding ;
Cellular component	cytoplasm ; clathrin-coated endocytic vesicle membrane ; membrane ; Golgi membrane ; plasma membrane ; synapse ; early endosome ; endosome ; cytosol ; neuronal cell body ; perinuclear region of cytoplasm ; basal dendrite ; presynapse ; synaptic vesicle membrane ; photoreceptor ribbon synapse ; Schaffer collateral - CA1 synapse ; hippocampal mossy fiber to CA3 synapse ; glutamatergic synapse ; presynaptic cytosol ;
Biological process	negative regulation of epidermal growth factor receptor signaling pathway ; endocytosis ; antigen processing and presentation of exogenous peptide antigen via MHC class II ; central nervous system development ; synaptic vesicle endocytosis ; regulation of receptor internalization ; signal transduction ; membrane organization ; synaptic vesicle uncoating ; neuron projection development ; dendrite extension ; cellular response to brain-derived neurotrophic factor stimulus ; lipid tube assembly ; membrane tubulation ; membrane bending ; vesicle scission ; positive regulation of membrane tubulation ; regulation of clathrin-dependent endocytosis ;
	Sources:Amigo / QuickGO
Orthologs
	6456
	20404
	ENSG00000107295
	ENSMUSG00000028488
	Q99962
	Q62420
	NM_003026
	NM_019535
	NP_003017
	NP_062408
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 30, 2023

Endophilin-A1 is a protein that in humans is encoded by the SH3GL2 gene.^[5]^[6]

Interactions

SH3GL2 has been shown to interact with DNM1,^[7]^[8] Amphiphysin,^[7]^[8] ADAM9,^[9] SH3KBP1 ^[10] and ADAM15.^[9]

Related Research Articles

Amphiphysin is a protein that in humans is encoded by the AMPH gene.

Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene.

Synaptojanin is a protein involved in vesicle uncoating in neurons. This is an important regulatory lipid phosphatase. It dephosphorylates the D-5 position phosphate from phosphatidylinositol (3,4,5)-trisphosphate (PIP₃) and Phosphatidylinositol (4,5)-bisphosphate(PIP₂). It belongs to family of 5-phosphatases, which are structurally unrelated to D-3 inositol phosphatases like PTEN. Other members of the family of 5'phosphoinositide phosphatases include OCRL, SHIP1, SHIP2, INPP5J, INPP5E, INPP5B, INPP5A and SKIP.

Cbl is a mammalian gene encoding the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ubiquitination. Mutations to this gene have been implicated in a number of human cancers, particularly acute myeloid leukaemia.

Myc box-dependent-interacting protein 1, also known as Bridging Integrator-1 and Amphiphysin-2 is a protein that in humans is encoded by the BIN1 gene.

SH3 domain-containing kinase-binding protein 1 is an adaptor protein that in humans is encoded by the SH3KBP1 gene.

Dynamin-2 is a protein that in humans is encoded by the DNM2 gene.

CBL-B is an E3 ubiquitin-protein ligase that in humans is encoded by the CBLB gene. CBLB is a member of the CBL gene family.

Disintegrin and metalloproteinase domain-containing protein 15 is an enzyme that in humans is encoded by the ADAM15 gene.

Cytoplasmic protein NCK1 is a protein that in humans is encoded by the NCK1 gene.

Dynamin-1 is a protein that in humans is encoded by the DNM1 gene.

Ena/VASP-like protein is a member of the Ena/VASP family of proteins that in humans is encoded by the EVL gene.

Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.

Endophilin-A3 is a protein that in humans is encoded by the SH3GL3 gene.

Endophilin-A2 is a protein that in humans is encoded by the SH3GL1 gene.

Sperm-associated antigen 5 is a protein that in humans is encoded by the SPAG5 gene.

Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.

Protein kinase C and casein kinase substrate in neurons protein 3 is an enzyme that in humans is encoded by the PACSIN3 gene.

Endophilin-B2 is a protein that in humans is encoded by the SH3GLB2 gene.

Ubiquitin-associated and SH3 domain-containing protein A is a protein that in humans is encoded by the UBASH3A gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000107295 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028488 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Giachino C; Lantelme E; Lanzetti L; Saccone S; Bella Valle G; Migone N (Jul 1997). "A novel SH3-containing human gene family preferentially expressed in the central nervous system". Genomics. 41 (3): 427–34. doi:10.1006/geno.1997.4645. PMID 9169142.
↑ "Entrez Gene: SH3GL2 SH3-domain GRB2-like 2".
1 2 Micheva, K D; Kay B K; McPherson P S (Oct 1997). "Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin". J. Biol. Chem. UNITED STATES. 272 (43): 27239–45. doi: 10.1074/jbc.272.43.27239 . ISSN 0021-9258. PMID 9341169.
1 2 Modregger, Jan; Schmidt Anne A; Ritter Brigitte; Huttner Wieland B; Plomann Markus (Feb 2003). "Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1". J. Biol. Chem. United States. 278 (6): 4160–7. doi: 10.1074/jbc.M208568200 . ISSN 0021-9258. PMID 12456676.
1 2 Howard, L; Nelson K K; Maciewicz R A; Blobel C P (Oct 1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J. Biol. Chem. UNITED STATES. 274 (44): 31693–9. doi: 10.1074/jbc.274.44.31693 . ISSN 0021-9258. PMID 10531379.
↑ Soubeyran, Philippe; Kowanetz Katarzyna; Szymkiewicz Iwona; Langdon Wallace Y; Dikic Ivan (Mar 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature . England. 416 (6877): 183–7. Bibcode:2002Natur.416..183S. doi:10.1038/416183a. ISSN 0028-0836. PMID 11894095. S2CID 635702.

Ren Y, Fang F, Davey F, Taylor M, Aiton J, Coote P, Yao J, Chen JX, Yan SD & Gunn-Moore FJ. (2008). "Endophilin I expression is increased in the brains of Alzheimer's disease patients". Journal of Biological Chemistry. 283 (9): 5685–91. doi: 10.1074/jbc.M707932200 . PMID 18167351.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Reutens AT; Begley CG (2002). "Endophilin-1: a multifunctional protein". Int. J. Biochem. Cell Biol. 34 (10): 1173–7. doi:10.1016/S1357-2725(02)00063-8. PMID 12127567.
So CW, Caldas C, Liu MM, et al. (1997). "EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia". Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2563–8. Bibcode:1997PNAS...94.2563S. doi: 10.1073/pnas.94.6.2563 . PMC 20128 . PMID 9122235.
Ringstad N; Nemoto Y; De Camilli P (1997). "The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8569–74. Bibcode:1997PNAS...94.8569R. doi: 10.1073/pnas.94.16.8569 . PMC 23017 . PMID 9238017.
Micheva KD; Ramjaun AR; Kay BK; McPherson PS (1997). "SH3 domain-dependent interactions of endophilin with amphiphysin". FEBS Lett. 414 (2): 308–12. doi: 10.1016/S0014-5793(97)01016-8 . PMID 9315708. S2CID 21328416.
Micheva KD; Kay BK; McPherson PS (1997). "Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin". J. Biol. Chem. 272 (43): 27239–45. doi: 10.1074/jbc.272.43.27239 . PMID 9341169.
Howard L; Nelson KK; Maciewicz RA; Blobel CP (1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J. Biol. Chem. 274 (44): 31693–9. doi: 10.1074/jbc.274.44.31693 . PMID 10531379.
Tang Y, Hu LA, Miller WE, et al. (1999). "Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12559–64. Bibcode:1999PNAS...9612559T. doi: 10.1073/pnas.96.22.12559 . PMC 22990 . PMID 10535961.
Cestra G, Castagnoli L, Dente L, et al. (1999). "The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity". J. Biol. Chem. 274 (45): 32001–7. doi: 10.1074/jbc.274.45.32001 . PMID 10542231.
So CW, So CK, Cheung N, et al. (2000). "The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis". Leukemia. 14 (4): 594–601. doi: 10.1038/sj.leu.2401692 . PMID 10764144.
So CW, Sham MH, Chew SL, et al. (2000). "Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins". Biochem. J. 348 (2): 447–58. doi:10.1042/0264-6021:3480447. PMC 1221085 . PMID 10816441.
Zucconi A, Dente L, Santonico E, et al. (2001). "Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1". J. Mol. Biol. 307 (5): 1329–39. doi:10.1006/jmbi.2001.4572. PMID 11292345.
Ramjaun AR, Angers A, Legendre-Guillemin V, et al. (2001). "Endophilin regulates JNK activation through its interaction with the germinal center kinase-like kinase". J. Biol. Chem. 276 (31): 28913–9. doi: 10.1074/jbc.M103198200 . PMID 11384986.
Chen-Hwang MC; Chen HR; Elzinga M; Hwang YW (2002). "Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate". J. Biol. Chem. 277 (20): 17597–604. doi: 10.1074/jbc.M111101200 . PMID 11877424.
Soubeyran P, Kowanetz K, Szymkiewicz I, et al. (2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature. 416 (6877): 183–7. Bibcode:2002Natur.416..183S. doi:10.1038/416183a. PMID 11894095. S2CID 635702.
Petrelli A, Gilestro GF, Lanzardo S, et al. (2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature. 416 (6877): 187–90. Bibcode:2002Natur.416..187P. doi:10.1038/416187a. PMID 11894096. S2CID 4389099.
Chatellard-Causse C, Blot B, Cristina N, et al. (2002). "Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization". J. Biol. Chem. 277 (32): 29108–15. doi: 10.1074/jbc.M204019200 . PMID 12034747.
Szymkiewicz I, Kowanetz K, Soubeyran P, et al. (2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases". J. Biol. Chem. 277 (42): 39666–72. doi: 10.1074/jbc.M205535200 . PMID 12177062.
Haglund K; Shimokawa N; Szymkiewicz I; Dikic I (2002). "Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12191–6. Bibcode:2002PNAS...9912191H. doi: 10.1073/pnas.192462299 . PMC 129420 . PMID 12218189.
Verstreken P, Kjaerulff O, Lloyd TE, et al. (2002). "Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release". Cell. 109 (1): 101–12. doi: 10.1016/S0092-8674(02)00688-8 . PMID 11955450. S2CID 11752921.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000107295 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028488 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9169142-5] Giachino C; Lantelme E; Lanzetti L; Saccone S; Bella Valle G; Migone N (Jul 1997). "A novel SH3-containing human gene family preferentially expressed in the central nervous system". Genomics. 41 (3): 427–34. doi:10.1006/geno.1997.4645. PMID 9169142.

[entrez-6] "Entrez Gene: SH3GL2 SH3-domain GRB2-like 2".

[pmid9341169-7] 1 2 Micheva, K D; Kay B K; McPherson P S (Oct 1997). "Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin". J. Biol. Chem. UNITED STATES. 272 (43): 27239–45. doi: 10.1074/jbc.272.43.27239 . ISSN 0021-9258. PMID 9341169.

[pmid12456676-8] 1 2 Modregger, Jan; Schmidt Anne A; Ritter Brigitte; Huttner Wieland B; Plomann Markus (Feb 2003). "Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1". J. Biol. Chem. United States. 278 (6): 4160–7. doi: 10.1074/jbc.M208568200 . ISSN 0021-9258. PMID 12456676.

[pmid10531379-9] 1 2 Howard, L; Nelson K K; Maciewicz R A; Blobel C P (Oct 1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J. Biol. Chem. UNITED STATES. 274 (44): 31693–9. doi: 10.1074/jbc.274.44.31693 . ISSN 0021-9258. PMID 10531379.

[pmid11894095-10] Soubeyran, Philippe; Kowanetz Katarzyna; Szymkiewicz Iwona; Langdon Wallace Y; Dikic Ivan (Mar 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature . England. 416 (6877): 183–7. Bibcode:2002Natur.416..183S. doi:10.1038/416183a. ISSN 0028-0836. PMID 11894095. S2CID 635702.

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SH3GL2

Contents

Interactions

Related Research Articles

References

Further reading