SH3GL2

SH3GL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X03, 1X04, 2D4C, 2DBM
Identifiers
Aliases	SH3GL2 , CNSA2, EEN-B1, SH3D2A, SH3P4, SH3 domain containing GRB2 like 2, endophilin A1
External IDs	OMIM: 604465; MGI: 700009; HomoloGene: 20652; GeneCards: SH3GL2; OMA:SH3GL2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9p22.2 Start 17,579,066 bp [1] End 17,797,124 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4 C4|4 40.23 cM Start 85,123,363 bp [2] End 85,557,432 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 middle temporal gyrus endothelial cell cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum cerebellar vermis primary visual cortex lateral nuclear group of thalamus orbitofrontal cortex Top expressed in transitional epithelium of urinary bladder lobe of cerebellum cerebellar vermis pontine nuclei subiculum habenula deep cerebellar nuclei medial vestibular nucleus motor neuron medial dorsal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding lipid binding identical protein binding protein homodimerization activity protein C-terminus binding protein kinase binding Cellular component cytoplasm clathrin-coated endocytic vesicle membrane membrane Golgi membrane plasma membrane synapse early endosome endosome cytosol soma perinuclear region of cytoplasm basal dendrite presynapse synaptic vesicle membrane photoreceptor ribbon synapse Schaffer collateral - CA1 synapse hippocampal mossy fiber to CA3 synapse glutamatergic synapse presynaptic cytosol Biological process negative regulation of epidermal growth factor receptor signaling pathway endocytosis antigen processing and presentation of exogenous peptide antigen via MHC class II central nervous system development synaptic vesicle endocytosis regulation of receptor internalization signal transduction membrane organization synaptic vesicle uncoating neuron projection development dendrite extension cellular response to brain-derived neurotrophic factor stimulus lipid tube assembly membrane tubulation membrane bending vesicle scission positive regulation of membrane tubulation regulation of clathrin-dependent endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6456 20404 Ensembl ENSG00000107295 ENSMUSG00000028488 UniProt Q99962 Q62420 RefSeq (mRNA) NM_003026 NM_019535 RefSeq (protein) NP_003017 NP_062408 Location (UCSC) Chr 9: 17.58 – 17.8 Mb Chr 4: 85.12 – 85.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Endophilin-A1 is a protein that in humans is encoded by the SH3GL2 gene. ^{[5] [6]}

Interactions

SH3GL2 has been shown to interact with DNM1, ^{[7] [8]} Amphiphysin, ^{[7] [8]} ADAM9, ^[9] SH3KBP1 ^[10] and ADAM15. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000107295 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028488 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Giachino C; Lantelme E; Lanzetti L; Saccone S; Bella Valle G; Migone N (Jul 1997). "A novel SH3-containing human gene family preferentially expressed in the central nervous system". Genomics. 41 (3): 427–34. doi:10.1006/geno.1997.4645. PMID   9169142.
6. "Entrez Gene: SH3GL2 SH3-domain GRB2-like 2".
7. Micheva, K D; Kay B K; McPherson P S (Oct 1997). "Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin". J. Biol. Chem. 272 (43). UNITED STATES: 27239–45. doi: 10.1074/jbc.272.43.27239 . ISSN   0021-9258. PMID   9341169.
8. Modregger, Jan; Schmidt Anne A; Ritter Brigitte; Huttner Wieland B; Plomann Markus (Feb 2003). "Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1". J. Biol. Chem. 278 (6). United States: 4160–7. doi: 10.1074/jbc.M208568200 . ISSN   0021-9258. PMID   12456676.
9. Howard, L; Nelson K K; Maciewicz R A; Blobel C P (Oct 1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J. Biol. Chem. 274 (44). UNITED STATES: 31693–9. doi: 10.1074/jbc.274.44.31693 . ISSN   0021-9258. PMID   10531379.
10. Soubeyran, Philippe; Kowanetz Katarzyna; Szymkiewicz Iwona; Langdon Wallace Y; Dikic Ivan (Mar 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature . 416 (6877). England: 183–7. Bibcode:2002Natur.416..183S. doi:10.1038/416183a. ISSN   0028-0836. PMID   11894095. S2CID   635702.

Further reading

• Ren Y, Fang F, Davey F, Taylor M, Aiton J, Coote P, Yao J, Chen JX, Yan SD & Gunn-Moore FJ. (2008). "Endophilin I expression is increased in the brains of Alzheimer's disease patients". Journal of Biological Chemistry. 283 (9): 5685–91. doi: 10.1074/jbc.M707932200 . PMID   18167351.
• Reutens AT; Begley CG (2002). "Endophilin-1: a multifunctional protein". Int. J. Biochem. Cell Biol. 34 (10): 1173–7. doi:10.1016/S1357-2725(02)00063-8. PMID   12127567.
• So CW, Caldas C, Liu MM, et al. (1997). "EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia". Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2563–8. Bibcode:1997PNAS...94.2563S. doi: 10.1073/pnas.94.6.2563 . PMC   20128 . PMID   9122235.
• Ringstad N; Nemoto Y; De Camilli P (1997). "The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8569–74. Bibcode:1997PNAS...94.8569R. doi: 10.1073/pnas.94.16.8569 . PMC   23017 . PMID   9238017.
• Micheva KD; Ramjaun AR; Kay BK; McPherson PS (1997). "SH3 domain-dependent interactions of endophilin with amphiphysin". FEBS Lett. 414 (2): 308–12. doi: 10.1016/S0014-5793(97)01016-8 . PMID   9315708. S2CID   21328416.
• Micheva KD; Kay BK; McPherson PS (1997). "Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin". J. Biol. Chem. 272 (43): 27239–45. doi: 10.1074/jbc.272.43.27239 . PMID   9341169.
• Howard L; Nelson KK; Maciewicz RA; Blobel CP (1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J. Biol. Chem. 274 (44): 31693–9. doi: 10.1074/jbc.274.44.31693 . PMID   10531379.
• Tang Y, Hu LA, Miller WE, et al. (1999). "Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12559–64. Bibcode:1999PNAS...9612559T. doi: 10.1073/pnas.96.22.12559 . PMC   22990 . PMID   10535961.
• Cestra G, Castagnoli L, Dente L, et al. (1999). "The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity". J. Biol. Chem. 274 (45): 32001–7. doi: 10.1074/jbc.274.45.32001 . PMID   10542231.
• So CW, So CK, Cheung N, et al. (2000). "The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis". Leukemia. 14 (4): 594–601. doi: 10.1038/sj.leu.2401692 . PMID   10764144.
• So CW, Sham MH, Chew SL, et al. (2000). "Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins". Biochem. J. 348 (2): 447–58. doi:10.1042/0264-6021:3480447. PMC   1221085 . PMID   10816441.
• Zucconi A, Dente L, Santonico E, et al. (2001). "Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1". J. Mol. Biol. 307 (5): 1329–39. doi:10.1006/jmbi.2001.4572. PMID   11292345.
• Ramjaun AR, Angers A, Legendre-Guillemin V, et al. (2001). "Endophilin regulates JNK activation through its interaction with the germinal center kinase-like kinase". J. Biol. Chem. 276 (31): 28913–9. doi: 10.1074/jbc.M103198200 . PMID   11384986.
• Chen-Hwang MC; Chen HR; Elzinga M; Hwang YW (2002). "Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate". J. Biol. Chem. 277 (20): 17597–604. doi: 10.1074/jbc.M111101200 . PMID   11877424.
• Soubeyran P, Kowanetz K, Szymkiewicz I, et al. (2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature. 416 (6877): 183–7. Bibcode:2002Natur.416..183S. doi:10.1038/416183a. PMID   11894095. S2CID   635702.
• Petrelli A, Gilestro GF, Lanzardo S, et al. (2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature. 416 (6877): 187–90. Bibcode:2002Natur.416..187P. doi:10.1038/416187a. PMID   11894096. S2CID   4389099.
• Chatellard-Causse C, Blot B, Cristina N, et al. (2002). "Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization". J. Biol. Chem. 277 (32): 29108–15. doi: 10.1074/jbc.M204019200 . PMID   12034747.
• Szymkiewicz I, Kowanetz K, Soubeyran P, et al. (2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases". J. Biol. Chem. 277 (42): 39666–72. doi: 10.1074/jbc.M205535200 . PMID   12177062.
• Haglund K; Shimokawa N; Szymkiewicz I; Dikic I (2002). "Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12191–6. Bibcode:2002PNAS...9912191H. doi: 10.1073/pnas.192462299 . PMC   129420 . PMID   12218189.
• Verstreken P, Kjaerulff O, Lloyd TE, et al. (2002). "Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release". Cell. 109 (1): 101–12. doi: 10.1016/S0092-8674(02)00688-8 . PMID   11955450. S2CID   11752921.