SH3GL3

SH3GL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EW3, 2Z0V
Identifiers
Aliases	SH3GL3 , CNSA3, EEN-B2, HsT19371, SH3D2C, SH3P13, SH3 domain containing GRB2 like endophilin A3, SH3 domain containing GRB2 like 3, endophilin A3
External IDs	OMIM: 603362 MGI: 700011 HomoloGene: 37723 GeneCards: SH3GL3
Gene location (Human)
Chr.	Chromosome 15 (human)
End	83,618,743 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	82,307,419 bp
RNA expression pattern
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding ; • identical protein binding ; • lipid binding ; • protein C-terminus binding ;
Cellular component	• cytoplasm ; • endosome ; • early endosome ; • early endosome membrane ; • membrane ; • acrosomal vesicle ; • synapse ; • presynapse ; • postsynaptic endosome ; • glutamatergic synapse ; • postsynaptic density, intracellular component ;
Biological process	• central nervous system development ; • endocytosis ; • signal transduction ; • positive regulation of neuron differentiation ; • negative regulation of clathrin-dependent endocytosis ; • regulation of clathrin-dependent endocytosis ;
	Sources:Amigo / QuickGO
Orthologs
	6457
	20408
	ENSG00000140600
	ENSMUSG00000030638
	Q99963
	Q62421
NM_001301108 ; NM_001301109 ; NM_003027 ; NM_001324182 ; NM_001324183 ;
	NM_001324184 ; NM_001324185 ; NM_001324186 ; NM_001324187 Contents Interactions ; References ; Further reading ;
	NM_001277954 ; NM_001277955 ; NM_017400
NP_001288037 ; NP_001288038 ; NP_001311111 ; NP_001311112 ; NP_001311113 ;
	NP_001311114 ; NP_001311115 ; NP_001311116 ; NP_003018
	NP_001264883 ; NP_001264884 ; NP_059096
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 06, 2021

Endophilin-A3 is a protein that in humans is encoded by the SH3GL3 gene.^[5]^[6]

Interactions

SH3GL3 has been shown to interact with Huntingtin ^[7] and SH3KBP1.^[8]

Related Research Articles

Huntingtin(Htt), is the protein coded for by the HTT gene, also known as the IT15 gene. Mutated HTT is the cause of Huntington's disease (HD), and has been investigated for this role and also for its involvement in long-term memory storage.

Huntingtin-interacting protein 1 also known as HIP-1 is a protein that in humans is encoded by the HIP1 gene.

In molecular biology, BAR domains are highly conserved protein dimerisation domains that occur in many proteins involved in membrane dynamics in a cell. The BAR domain is banana-shaped and binds to membrane via its concave face. It is capable of sensing membrane curvature by binding preferentially to curved membranes. BAR domains are named after three proteins that they are found in: Bin, Amphiphysin and Rvs.

Amphiphysin is a protein that in humans is encoded by the AMPH gene.

Synaptojanin is a protein involved in vesicle uncoating in neurons. This is an important regulatory lipid phosphatase. It dephosphorylates the D-5 position phosphate from phosphatidylinositol (3,4,5)-trisphosphate (PIP₃) and Phosphatidylinositol (4,5)-bisphosphate(PIP₂). It belongs to family of 5-phosphatases, which are structurally unrelated to D-3 inositol phosphatases like PTEN. Other members of the family of 5'phosphoinositide phosphatases include OCRL, SHIP1, SHIP2, INPP5J, INPP5E, INPP5B, INPP5A and SKIP.

Cbl is a mammalian gene encoding the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ubiquitination. Mutations to this gene have been implicated in a number of human cancers, particularly acute myeloid leukaemia.

SH3 domain-containing kinase-binding protein 1 is an adaptor protein that in humans is encoded by the SH3KBP1 gene.

Dynamin-2 is a protein that in humans is encoded by the DNM2 gene.

Dynamin-1 is a protein that in humans is encoded by the DNM1 gene.

ARF GTPase-activating protein GIT1 is an enzyme that in humans is encoded by the GIT1 gene.

Endophilin-A1 is a protein that in humans is encoded by the SH3GL2 gene.

Dynamin-1-like protein is a GTPase that regulates mitochondrial fission. In humans, dynamin-1-like protein, which is typically referred to as dynamin-related protein 1 (Drp1), is encoded by the DNM1L gene.

Elongation factor 1-gamma is a protein that in humans is encoded by the EEF1G gene.

Transcriptional adapter 3-like is a protein that in humans is encoded by the TADA3 gene. Cytogenetic location: 3p25.3

Histone acetyltransferase KAT7 is an enzyme that in humans is encoded by the KAT7 gene. It specifically acetylates H4 histones at the lysine12 residue (H4K12) and is necessary for origin licensing and DNA replication. KAT7 associates with origins of replication during G1 phase of the cell cycle through complexing with CDT1. Geminin is thought to inhibit the acetyltransferase activity of KAT7 when KAT7 and CDT1 are complexed together.

Endophilin-A2 is a protein that in humans is encoded by the SH3GL1 gene.

Protein kinase C and casein kinase substrate in neurons protein 1 is an enzyme that in humans is encoded by the PACSIN1 gene.

Ubiquitin-conjugating enzyme E2 K is a protein that in humans is encoded by the UBE2K gene.

SH3 domain-binding protein 1 is a protein that in humans is encoded by the SH3BP1 gene.

Endophilin-B2 is a protein that in humans is encoded by the SH3GLB2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000140600 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030638 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Giachino C, Lantelme E, Lanzetti L, Saccone S, Bella Valle G, Migone N (July 1997). "A novel SH3-containing human gene family preferentially expressed in the central nervous system". Genomics. 41 (3): 427–34. doi:10.1006/geno.1997.4645. PMID 9169142.
↑ "Entrez Gene: SH3GL3 SH3-domain GRB2-like 3".
↑ Sittler A, Wälter S, Wedemeyer N, Hasenbank R, Scherzinger E, Eickhoff H, Bates GP, Lehrach H, Wanker EE (October 1998). "SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates". Mol. Cell. 2 (4): 427–36. doi: 10.1016/S1097-2765(00)80142-2 . PMID 9809064.
↑ Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature . 416 (6877): 187–90. doi:10.1038/416187a. PMID 11894096.

So CW, Caldas C, Liu MM, Chen SJ, Huang QH, Gu LJ, Sham MH, Wiedemann LM, Chan LC (1997). "EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia". Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2563–8. doi:10.1073/pnas.94.6.2563. PMC 20128 . PMID 9122235.
Ringstad N, Nemoto Y, De Camilli P (1997). "The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8569–74. doi:10.1073/pnas.94.16.8569. PMC 23017 . PMID 9238017.
Sittler A, Wälter S, Wedemeyer N, Hasenbank R, Scherzinger E, Eickhoff H, Bates GP, Lehrach H, Wanker EE (1998). "SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates". Mol. Cell. 2 (4): 427–36. doi: 10.1016/S1097-2765(00)80142-2 . PMID 9809064.
Tang Y, Hu LA, Miller WE, Ringstad N, Hall RA, Pitcher JA, DeCamilli P, Lefkowitz RJ (1999). "Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12559–64. doi:10.1073/pnas.96.22.12559. PMC 22990 . PMID 10535961.
Cestra G, Castagnoli L, Dente L, Minenkova O, Petrelli A, Migone N, Hoffmüller U, Schneider-Mergener J, Cesareni G (1999). "The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity". J. Biol. Chem. 274 (45): 32001–7. doi: 10.1074/jbc.274.45.32001 . PMID 10542231.
So CW, So CK, Cheung N, Chew SL, Sham MH, Chan LC (2000). "The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis". Leukemia. 14 (4): 594–601. doi: 10.1038/sj.leu.2401692 . PMID 10764144.
So CW, Sham MH, Chew SL, Cheung N, So CK, Chung SK, Caldas C, Wiedemann LM, Chan LC (2000). "Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins". Biochem. J. 348 (2): 447–58. doi:10.1042/0264-6021:3480447. PMC 1221085 . PMID 10816441.
Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature. 416 (6877): 187–90. doi:10.1038/416187a. PMID 11894096.
Chatellard-Causse C, Blot B, Cristina N, Torch S, Missotten M, Sadoul R (2002). "Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization". J. Biol. Chem. 277 (32): 29108–15. doi: 10.1074/jbc.M204019200 . PMID 12034747.
Verdier F, Valovka T, Zhyvoloup A, Drobot LB, Buchman V, Waterfield M, Gout I (2002). "Ruk is ubiquitinated but not degraded by the proteasome". Eur. J. Biochem. 269 (14): 3402–8. doi: 10.1046/j.1432-1033.2002.03031.x . PMID 12135478.
Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I (2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases". J. Biol. Chem. 277 (42): 39666–72. doi: 10.1074/jbc.M205535200 . PMID 12177062.
Otsuki M, Itoh T, Takenawa T (2003). "Neural Wiskott-Aldrich syndrome protein is recruited to rafts and associates with endophilin A in response to epidermal growth factor". J. Biol. Chem. 278 (8): 6461–9. doi: 10.1074/jbc.M207433200 . PMID 12477732.
Yam JW, Jin DY, So CW, Chan LC (2004). "Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein". Blood. 103 (4): 1445–53. doi: 10.1182/blood-2003-07-2452 . hdl:10722/48499. PMID 14551139.
Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U, Droege A, Lindenberg KS, Knoblich M, Haenig C, Herbst M, Suopanki J, Scherzinger E, Abraham C, Bauer B, Hasenbank R, Fritzsche A, Ludewig AH, Büssow K, Buessow K, Coleman SH, Gutekunst CA, Landwehrmeyer BG, Lehrach H, Wanker EE (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi: 10.1016/j.molcel.2004.09.016 . PMID 15383276.
Trevaskis J, Walder K, Foletta V, Kerr-Bayles L, McMillan J, Cooper A, Lee S, Bolton K, Prior M, Fahey R, Whitecross K, Morton GJ, Schwartz MW, Collier GR (2005). "Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance". Endocrinology. 146 (9): 3757–64. doi: 10.1210/en.2005-0282 . PMID 15919751.
Ralser M, Nonhoff U, Albrecht M, Lengauer T, Wanker EE, Lehrach H, Krobitsch S (2005). "Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways". Hum. Mol. Genet. 14 (19): 2893–909. doi: 10.1093/hmg/ddi321 . PMID 16115810.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID 16169070.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID 16713569.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000140600 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030638 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9169142-5] Giachino C, Lantelme E, Lanzetti L, Saccone S, Bella Valle G, Migone N (July 1997). "A novel SH3-containing human gene family preferentially expressed in the central nervous system". Genomics. 41 (3): 427–34. doi:10.1006/geno.1997.4645. PMID 9169142.

[entrez-6] "Entrez Gene: SH3GL3 SH3-domain GRB2-like 3".

[pmid9809064-7] Sittler A, Wälter S, Wedemeyer N, Hasenbank R, Scherzinger E, Eickhoff H, Bates GP, Lehrach H, Wanker EE (October 1998). "SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates". Mol. Cell. 2 (4): 427–36. doi: 10.1016/S1097-2765(00)80142-2 . PMID 9809064.

[pmid11894096-8] Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature . 416 (6877): 187–90. doi:10.1038/416187a. PMID 11894096.

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SH3GL3

Contents

Interactions

Related Research Articles

References

Further reading