SH3PXD2A

SH3PXD2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DNU, 2EGA, 2EGC, 2EKH
Identifiers
Aliases	SH3PXD2A , FISH, SH3MD1, TKS5, SH3 and PX domains 2A
External IDs	MGI: 1298393; HomoloGene: 7317; GeneCards: SH3PXD2A; OMA:SH3PXD2A - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q24.33 Start 103,594,027 bp [1] End 103,855,543 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 C3 Start 47,248,613 bp [2] End 47,452,840 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cervix sural nerve trigeminal ganglion tibia inferior ganglion of vagus nerve myometrium vagina cecum tendon Top expressed in molar gastrula ascending aorta sciatic nerve aortic valve body of femur umbilical cord calvaria skin of abdomen utricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding superoxide-generating NADPH oxidase activator activity phosphatidylinositol binding protease binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-5-phosphate binding phosphatidylinositol-3-phosphate binding phosphatidylinositol-3,4-bisphosphate binding phosphatidylinositol-4-phosphate binding Cellular component cytoplasm podosome cell junction cell projection cytosol Biological process osteoclast fusion superoxide metabolic process reactive oxygen species metabolic process positive regulation of catalytic activity podosome assembly extracellular matrix organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9644 14218 Ensembl ENSG00000107957 ENSMUSG00000053617 UniProt Q5TCZ1 O89032 RefSeq (mRNA) NM_014631 NM_001365079 NM_001164717 NM_008018 NM_177833 RefSeq (protein) NP_055446 NP_001352008 NP_001158189 NP_032044 Location (UCSC) Chr 10: 103.59 – 103.86 Mb Chr 19: 47.25 – 47.45 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SH3 and PX domain-containing protein 2A is a protein that in humans is encoded by the SH3PXD2A gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000107957 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053617 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lock P, Abram CL, Gibson T, Courtneidge SA (Sep 1998). "A new method for isolating tyrosine kinase substrates used to identify fish, an SH3 and PX domain-containing protein, and Src substrate". EMBO J. 17 (15): 4346–57. doi:10.1093/emboj/17.15.4346. PMC   1170768 . PMID   9687503.
6. "Entrez Gene: SH3PXD2A SH3 and PX domains 2A".

Further reading

• Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi: 10.1093/dnares/4.5.307 . PMID   9455477.
• Abram CL, Seals DF, Pass I, et al. (2003). "The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells". J. Biol. Chem. 278 (19): 16844–51. doi: 10.1074/jbc.M300267200 . PMID   12615925.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID   15164054.
• Seals DF, Azucena EF, Pass I, et al. (2005). "The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells". Cancer Cell. 7 (2): 155–65. doi: 10.1016/j.ccr.2005.01.006 . PMID   15710328.
• Malinin NL, Wright S, Seubert P, et al. (2005). "Amyloid-beta neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity". Proc. Natl. Acad. Sci. U.S.A. 102 (8): 3058–63. Bibcode:2005PNAS..102.3058M. doi: 10.1073/pnas.0408237102 . PMC   549444 . PMID   15710903.
• Harold D, Jehu L, Turic D, et al. (2007). "Interaction between the ADAM12 and SH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (4): 448–52. doi:10.1002/ajmg.b.30456. PMID   17440933. S2CID   13922599.