SH3PXD2A

SH3PXD2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DNU, 2EGA, 2EGC, 2EKH
Identifiers
Aliases	SH3PXD2A , FISH, SH3MD1, TKS5, SH3 and PX domains 2A
External IDs	MGI: 1298393 HomoloGene: 7317 GeneCards: SH3PXD2A
Gene location (Human)
Chr.	Chromosome 10 (human)
End	103,855,543 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	47,464,401 bp
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding ; • superoxide-generating NADPH oxidase activator activity ; • phosphatidylinositol binding ; • protease binding ; • phosphatidylinositol-4,5-bisphosphate binding ; • phosphatidylinositol-5-phosphate binding ; • phosphatidylinositol-3-phosphate binding ; • phosphatidylinositol-3,4-bisphosphate binding ; • phosphatidylinositol-4-phosphate binding ;
Cellular component	• cytoplasm ; • podosome ; • cell junction ; • cell projection ; • cytosol ;
Biological process	• osteoclast fusion ; • superoxide metabolic process ; • reactive oxygen species metabolic process ; • GO:0048554 positive regulation of catalytic activity ; • podosome assembly ; • extracellular matrix organization ;
	Sources:Amigo / QuickGO
Orthologs
	9644
	14218
	ENSG00000107957
	ENSMUSG00000053617
	Q5TCZ1
	O89032
	NM_014631 ; NM_001365079
	NM_001164717 ; NM_008018 ; NM_177833
	NP_055446 ; NP_001352008
	NP_001158189 ; NP_032044
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 07, 2021

SH3 and PX domain-containing protein 2A is a protein that in humans is encoded by the SH3PXD2A gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000107957 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053617 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lock P, Abram CL, Gibson T, Courtneidge SA (Sep 1998). "A new method for isolating tyrosine kinase substrates used to identify fish, an SH3 and PX domain-containing protein, and Src substrate". EMBO J. 17 (15): 4346–57. doi:10.1093/emboj/17.15.4346. PMC 1170768 . PMID 9687503.
↑ "Entrez Gene: SH3PXD2A SH3 and PX domains 2A".

Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi: 10.1093/dnares/4.5.307 . PMID 9455477.
Abram CL, Seals DF, Pass I, et al. (2003). "The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells". J. Biol. Chem. 278 (19): 16844–51. doi: 10.1074/jbc.M300267200 . PMID 12615925.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi: 10.1038/nature02462 . PMID 15164054.
Seals DF, Azucena EF, Pass I, et al. (2005). "The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells". Cancer Cell. 7 (2): 155–65. doi: 10.1016/j.ccr.2005.01.006 . PMID 15710328.
Malinin NL, Wright S, Seubert P, et al. (2005). "Amyloid-beta neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity". Proc. Natl. Acad. Sci. U.S.A. 102 (8): 3058–63. doi:10.1073/pnas.0408237102. PMC 549444 . PMID 15710903.
Harold D, Jehu L, Turic D, et al. (2007). "Interaction between the ADAM12 and SH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (4): 448–52. doi:10.1002/ajmg.b.30456. PMID 17440933. S2CID 13922599.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000107957 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053617 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9687503-5] Lock P, Abram CL, Gibson T, Courtneidge SA (Sep 1998). "A new method for isolating tyrosine kinase substrates used to identify fish, an SH3 and PX domain-containing protein, and Src substrate". EMBO J. 17 (15): 4346–57. doi:10.1093/emboj/17.15.4346. PMC 1170768 . PMID 9687503.

[entrez-6] "Entrez Gene: SH3PXD2A SH3 and PX domains 2A".

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SH3PXD2A

Related Research Articles

References

Further reading