SH3RF1

SH3RF1
Identifiers
Aliases	SH3RF1 , POSH, RNF142, SH3MD2, SH3 domain containing ring finger 1
External IDs	MGI: 1913066 HomoloGene: 10988 GeneCards: SH3RF1
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q32.3-q33 Start 169,094,259 bp [1] End 169,270,956 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 B3.1 Start 61,676,906 bp [2] End 61,849,105 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic epithelial cell palpebral conjunctiva pancreatic ductal cell endothelial cell germinal epithelium jejunal mucosa pylorus amniotic fluid lactiferous duct stromal cell of endometrium Top expressed in seminal vesicula medial ganglionic eminence conjunctival fornix vas deferens secondary oocyte retinal pigment epithelium ciliary body left lung lobe molar Region I of hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding transferase activity MAP-kinase scaffold activity ubiquitin protein ligase activity Cellular component cytoplasm perinuclear region of cytoplasm cytosol Golgi apparatus cell projection lamellipodium Biological process negative regulation of extrinsic apoptotic signaling pathway negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of apoptotic process regulation of JNK cascade protein ubiquitination apoptotic process neuron migration regulation of CD4-positive, alpha-beta T cell differentiation protein autoubiquitination regulation of CD8-positive, alpha-beta T cell proliferation positive regulation of JNK cascade Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57630 59009 Ensembl ENSG00000154447 ENSMUSG00000031642 UniProt Q7Z6J0 Q69ZI1 RefSeq (mRNA) NM_020870 NM_021506 NM_198678 RefSeq (protein) NP_065921 NP_067481 Location (UCSC) Chr 4: 169.09 – 169.27 Mb Chr 8: 61.68 – 61.85 Mb PubMed search [3] [4]
Wikidata
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Putative E3 ubiquitin-protein ligase SH3RF1 is an enzyme that in humans is encoded by the SH3RF1 gene. ^{[5] [6]}

Function

This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as a ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. ^[6]

Interactions

SH3RF1 has been shown to interact with AKT2 ^[7] and MAP3K11. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000154447 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031642 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tapon N, Nagata K, Lamarche N, Hall A (Apr 1998). "A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways". EMBO J. 17 (5): 1395–404. doi:10.1093/emboj/17.5.1395. PMC   1170487 . PMID   9482736.
6. "Entrez Gene: SH3RF1 SH3 domain containing ring finger 1".
7. Figueroa C, Tarras S, Taylor J, Vojtek AB (Nov 2003). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J. Biol. Chem. 278 (48): 47922–7. doi: 10.1074/jbc.M307357200 . PMID   14504284.

Further reading

• Lyons TR, Thorburn J, Ryan PW, Thorburn A, Anderson SM, Kassenbrock CK (2007). "Regulation of the Pro-apoptotic scaffolding protein POSH by Akt". J. Biol. Chem. 282 (30): 21987–97. doi: 10.1074/jbc.M704321200 . PMID   17535800.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Alroy I, Tuvia S, Greener T, Gordon D, Barr HM, Taglicht D, Mandil-Levin R, Ben-Avraham D, Konforty D, Nir A, Levius O, Bicoviski V, Dori M, Cohen S, Yaar L, Erez O, Propheta-Meiran O, Koskas M, Caspi-Bachar E, Alchanati I, Sela-Brown A, Moskowitz H, Tessmer U, Schubert U, Reiss Y (2005). "The trans-Golgi network-associated human ubiquitin-protein ligase POSH is essential for HIV type 1 production". Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1478–83. Bibcode:2005PNAS..102.1478A. doi: 10.1073/pnas.0408717102 . PMC   545085 . PMID   15659549.
• Figueroa C, Tarras S, Taylor J, Vojtek AB (2003). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J. Biol. Chem. 278 (48): 47922–7. doi: 10.1074/jbc.M307357200 . PMID   14504284.
• Nakayama M, Kikuno R, Ohara O (2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC   187542 . PMID   12421765.
• Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi: 10.1093/dnares/7.2.143 . PMID   10819331.