SHC3

SHC3
Identifiers
Aliases	SHC3 , N-Shc, NSHC, RAI, SHCC, SHC adaptor protein 3
External IDs	OMIM: 605263 MGI: 106179 HomoloGene: 7536 GeneCards: SHC3
Gene location (Human)
Chr.	Chromosome 9 (human)
End	89,178,818 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	51,723,523 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; endothelial cell; ; superior frontal gyrus; ; postcentral gyrus; ; entorhinal cortex; ; orbitofrontal cortex; ; frontal pole; ; dorsolateral prefrontal cortex; ; Brodmann area 46;
	Top expressed in
	superior frontal gyrus; ; superior surface of tongue; ; gallbladder; ; secondary oocyte; ; morula; ; medial dorsal nucleus; ; lateral geniculate nucleus; ; cingulate gyrus; ; entorhinal cortex; ; hippocampus proper;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	receptor tyrosine kinase binding ; signal transducer activity ; protein binding ; phosphotyrosine residue binding ;
Cellular component	cytosol ; plasma membrane ; cellular component ;
Biological process	intracellular signal transduction ; epidermal growth factor receptor signaling pathway ; synaptic transmission, glutamatergic ; transmembrane receptor protein tyrosine kinase signaling pathway ; MAPK cascade ; central nervous system development ; learning or memory ; Ras protein signal transduction ; signal transduction ; axon guidance ;
	Sources:Amigo / QuickGO
Orthologs
	53358
	20418
	ENSG00000148082
	ENSMUSG00000021448
	Q92529
	Q61120
	NM_016848
	NM_009167
	NP_058544
	NP_033193
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 28, 2023

SHC-transforming protein 3 is a protein that in humans is encoded by the SHC3 gene.^[5]^[6]

Interactions

SHC3 has been shown to interact with RICS ^[7] and TrkB.^[8]^[9]

Related Research Articles

Tyrosine-protein kinase ABL1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene located on chromosome 9. c-Abl is sometimes used to refer to the version of the gene found within the mammalian genome, while v-Abl refers to the viral gene, which was initially isolated from the Abelson murine leukemia virus.

Growth factor receptor-bound protein 7, also known as GRB7, is a protein that in humans is encoded by the GRB7 gene.

Tropomyosin receptor kinase A (TrkA), also known as high affinity nerve growth factor receptor, neurotrophic tyrosine kinase receptor type 1, or TRK1-transforming tyrosine kinase protein is a protein that in humans is encoded by the NTRK1 gene.

Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a protein that in humans is encoded by the NTRK2 gene. TrkB is a receptor for brain-derived neurotrophic factor (BDNF). Standard pronunciation is "track bee".

<span class="mw-page-title-main">GRB2</span> Protein-coding gene in the species Homo sapiens

Growth factor receptor-bound protein 2, also known as Grb2, is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2 protein is encoded by the GRB2 gene.

Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene.

Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene.

The RETproto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor (GDNF) family of extracellular signalling molecules. RET loss of function mutations are associated with the development of Hirschsprung's disease, while gain of function mutations are associated with the development of various types of human cancer, including medullary thyroid carcinoma, multiple endocrine neoplasias type 2A and 2B, pheochromocytoma and parathyroid hyperplasia.

Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene. It is also known as HPK1. The protein has been shown to play a role in JNK activation.

Cbl is a mammalian gene encoding the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ubiquitination. Mutations to this gene have been implicated in a number of human cancers, particularly acute myeloid leukaemia.

Crk-like protein is a protein that in humans is encoded by the CRKL gene.

Rap guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the RAPGEF1 gene.

Fibroblast growth factor receptor substrate 2 is a protein that in humans is encoded by the FRS2 gene.

Cytoplasmic protein NCK1 is a protein that in humans is encoded by the NCK1 gene.

GRB2-related adapter protein 2 also known as GRB2-related adaptor downstream of Shc (GADS) is a 37 kDa protein that in humans is encoded by the GRAP2 gene.

Protein TFG is a protein that in humans is encoded by the TFG gene.

SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene.

Fibroblast growth factor receptor substrate 3 is a protein that in humans is encoded by the FRS3 gene.

Rho GTPase-activating protein 32 is a protein that in humans is encoded by the RICS gene. RICS has two known isoforms, RICS that are expressed primarily at neurite growth cones, and at the post synaptic membranes, and PX-RICS which is more widely expressed in the endoplasmic reticulum, Golgi apparatus and endosomes. The only known domain of the RICS is the RhoGAP domain, whilst PX-RICS has an additional Phox homology and SH3 domain.

SHC-transforming protein 2 is a protein that in humans is encoded by the SHC2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000148082 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021448 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nakamura T, Sanokawa R, Sasaki Y, Ayusawa D, Oishi M, Mori N (September 1996). "N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway". Oncogene. 13 (6): 1111–21. PMID 8808684.
↑ "Entrez Gene: SHC3 SHC (Src homology 2 domain containing) transforming protein 3".
↑ Nakamura T, Komiya M, Sone K, Hirose E, Gotoh N, Morii H, Ohta Y, Mori N (December 2002). "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Molecular and Cellular Biology. 22 (24): 8721–34. doi:10.1128/MCB.22.24.8721-8734.2002. PMC 139861 . PMID 12446789.
↑ Nakamura T, Muraoka S, Sanokawa R, Mori N (March 1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". The Journal of Biological Chemistry. 273 (12): 6960–7. doi: 10.1074/jbc.273.12.6960 . PMID 9507002.
↑ Suzuki S, Mizutani M, Suzuki K, Yamada M, Kojima M, Hatanaka H, Koizumi S (June 2002). "Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor". Biochemical and Biophysical Research Communications. 294 (5): 1087–92. doi:10.1016/S0006-291X(02)00606-X. PMID 12074588.

O'Bryan JP, Songyang Z, Cantley L, Der CJ, Pawson T (April 1996). "A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain". Proceedings of the National Academy of Sciences of the United States of America. 93 (7): 2729–34. Bibcode:1996PNAS...93.2729O. doi: 10.1073/pnas.93.7.2729 . PMC 39699 . PMID 8610109.
Pelicci G, Dente L, De Giuseppe A, Verducci-Galletti B, Giuli S, Mele S, Vetriani C, Giorgio M, Pandolfi PP, Cesareni G, Pelicci PG (August 1996). "A family of Shc related proteins with conserved PTB, CH1 and SH2 regions". Oncogene. 13 (3): 633–41. PMID 8760305.
Menegon A, Leoni C, Benfenati F, Valtorta F (September 1997). "Tat protein from HIV-1 activates MAP kinase in granular neurons and glial cells from rat cerebellum". Biochemical and Biophysical Research Communications. 238 (3): 800–5. doi:10.1006/bbrc.1997.7393. PMID 9325171.
Wang JF, Ganju RK, Liu ZY, Avraham H, Avraham S, Groopman JE (November 1997). "Signal transduction in human hematopoietic cells by vascular endothelial growth factor related protein, a novel ligand for the FLT4 receptor". Blood. 90 (9): 3507–15. doi: 10.1182/blood.V90.9.3507 . PMID 9345034.
Nakamura T, Muraoka S, Sanokawa R, Mori N (March 1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". The Journal of Biological Chemistry. 273 (12): 6960–7. doi: 10.1074/jbc.273.12.6960 . PMID 9507002.
Cook KK, Fadool DA (April 2002). "Two adaptor proteins differentially modulate the phosphorylation and biophysics of Kv1.3 ion channel by SRC kinase". The Journal of Biological Chemistry. 277 (15): 13268–80. doi: 10.1074/jbc.M108898200 . PMC 2779217 . PMID 11812778.
Tarr PE, Roncarati R, Pelicci G, Pelicci PG, D'Adamio L (May 2002). "Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc". The Journal of Biological Chemistry. 277 (19): 16798–804. doi: 10.1074/jbc.M110286200 . PMID 11877420.
Liu HY, Meakin SO (July 2002). "ShcB and ShcC activation by the Trk family of receptor tyrosine kinases". The Journal of Biological Chemistry. 277 (29): 26046–56. doi: 10.1074/jbc.M111659200 . PMID 12006576.
Miyake I, Hakomori Y, Shinohara A, Gamou T, Saito M, Iwamatsu A, Sakai R (August 2002). "Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines". Oncogene. 21 (38): 5823–34. doi:10.1038/sj.onc.1205735. PMID 12185581. S2CID 27978633.
Pelicci G, Troglio F, Bodini A, Melillo RM, Pettirossi V, Coda L, De Giuseppe A, Santoro M, Pelicci PG (October 2002). "The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway". Molecular and Cellular Biology. 22 (20): 7351–63. doi:10.1128/MCB.22.20.7351-7363.2002. PMC 139827 . PMID 12242309.
Nakamura T, Komiya M, Sone K, Hirose E, Gotoh N, Morii H, Ohta Y, Mori N (December 2002). "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Molecular and Cellular Biology. 22 (24): 8721–34. doi:10.1128/MCB.22.24.8721-8734.2002. PMC 139861 . PMID 12446789.
Miyake I, Hakomori Y, Misu Y, Nakadate H, Matsuura N, Sakamoto M, Sakai R (April 2005). "Domain-specific function of ShcC docking protein in neuroblastoma cells". Oncogene. 24 (19): 3206–15. doi:10.1038/sj.onc.1208523. PMID 15735675. S2CID 22484454.
Magrassi L, Conti L, Lanterna A, Zuccato C, Marchionni M, Cassini P, Arienta C, Cattaneo E (August 2005). "Shc3 affects human high-grade astrocytomas survival". Oncogene. 24 (33): 5198–206. doi: 10.1038/sj.onc.1208708 . PMID 15870690.
De Falco V, Guarino V, Malorni L, Cirafici AM, Troglio F, Erreni M, Pelicci G, Santoro M, Melillo RM (September 2005). "RAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumors". Oncogene. 24 (41): 6303–13. doi: 10.1038/sj.onc.1208776 . PMID 15940252.
Toschi E, Bacigalupo I, Strippoli R, Chiozzini C, Cereseto A, Falchi M, Nappi F, Sgadari C, Barillari G, Mainiero F, Ensoli B (April 2006). "HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway". Molecular Biology of the Cell. 17 (4): 1985–94. doi:10.1091/mbc.E05-08-0717. PMC 1415297 . PMID 16436505.
Li MD, Sun D, Lou XY, Beuten J, Payne TJ, Ma JZ (May 2007). "Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence". Molecular Psychiatry. 12 (5): 462–73. doi:10.1038/sj.mp.4001933. PMID 17179996. S2CID 11319299.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000148082 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021448 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8808684-5] Nakamura T, Sanokawa R, Sasaki Y, Ayusawa D, Oishi M, Mori N (September 1996). "N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway". Oncogene. 13 (6): 1111–21. PMID 8808684.

[entrez-6] "Entrez Gene: SHC3 SHC (Src homology 2 domain containing) transforming protein 3".

[pmid12446789-7] Nakamura T, Komiya M, Sone K, Hirose E, Gotoh N, Morii H, Ohta Y, Mori N (December 2002). "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Molecular and Cellular Biology. 22 (24): 8721–34. doi:10.1128/MCB.22.24.8721-8734.2002. PMC 139861 . PMID 12446789.

[pmid9507002-8] Nakamura T, Muraoka S, Sanokawa R, Mori N (March 1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". The Journal of Biological Chemistry. 273 (12): 6960–7. doi: 10.1074/jbc.273.12.6960 . PMID 9507002.

[pmid12074588-9] Suzuki S, Mizutani M, Suzuki K, Yamada M, Kojima M, Hatanaka H, Koizumi S (June 2002). "Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor". Biochemical and Biophysical Research Communications. 294 (5): 1087–92. doi:10.1016/S0006-291X(02)00606-X. PMID 12074588.

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SHC3

Contents

Interactions

Related Research Articles

References

Further reading