SHPRH

SHPRH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M85, 4QN1
Identifiers
Aliases	SHPRH , bA545I5.2, SNF2 histone linker PHD RING helicase, RAD5
External IDs	OMIM: 608048; MGI: 1917581; HomoloGene: 6489; GeneCards: SHPRH; OMA:SHPRH - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q24.3 Start 145,864,245 bp [1] End 145,964,423 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 A1 Start 11,025,171 bp [2] End 11,093,339 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon testicle pancreatic epithelial cell sural nerve retinal pigment epithelium germinal epithelium gonad tibia skin of thigh bone marrow cells Top expressed in secondary oocyte lobe of cerebellum cerebellar vermis primary oocyte zygote genital tubercle lumbar subsegment of spinal cord ganglionic eminence trigeminal ganglion ventricular zone More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding nucleotide binding protein binding hydrolase activity ATP binding helicase activity metal ion binding ubiquitin-protein transferase activity ubiquitin protein ligase binding transferase activity ubiquitin protein ligase activity Cellular component nucleosome nucleus nucleoplasm Biological process nucleosome assembly protein polyubiquitination DNA repair cellular response to DNA damage stimulus protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 257218 268281 Ensembl ENSG00000146414 ENSMUSG00000090112 UniProt Q149N8 Q7TPQ3 RefSeq (mRNA) NM_001042683 NM_173082 NM_001370327 NM_001370328 NM_001077707 NM_001284354 NM_172937 RefSeq (protein) NP_001036148 NP_775105 NP_001357256 NP_001357257 NP_001071175 NP_001271283 NP_766525 Location (UCSC) Chr 6: 145.86 – 145.96 Mb Chr 10: 11.03 – 11.09 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

E3 ubiquitin-protein ligase SHPRH is an enzyme that in humans is encoded by the SHPRH gene. ^{[5] [6]}

Function

SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases.[supplied by OMIM] ^[6] SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000146414 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000090112 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sood R, Makalowska I, Galdzicki M, Hu P, Eddings E, Robbins CM, Moses T, Namkoong J, Chen S, Trent JM (August 2003). "Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region". Genomics. 82 (2): 153–61. doi:10.1016/S0888-7543(03)00121-6. PMID   12837266.
6. "Entrez Gene: SHPRH SNF2 histone linker PHD RING helicase".
7. Brühl, J; Trautwein, J; Schäfer, A; Linne, U; Bouazoune, K (21 August 2019). "The DNA repair protein SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase". Epigenetics & Chromatin. 12 (1): 52. doi: 10.1186/s13072-019-0294-5 . PMC   6702750 . PMID   31434570.

Further reading

• Motegi A, Sood R, Moinova H, Markowitz SD, Liu PP, Myung K (December 2006). "Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination". The Journal of Cell Biology. 175 (5): 703–8. doi:10.1083/jcb.200606145. PMC   2064669 . PMID   17130289.
• Unk I, Hajdú I, Fátyol K, Szakál B, Blastyák A, Bermudez V, Hurwitz J, Prakash L, Prakash S, Haracska L (November 2006). "Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen". Proceedings of the National Academy of Sciences of the United States of America. 103 (48): 18107–12. Bibcode:2006PNAS..10318107U. doi: 10.1073/pnas.0608595103 . PMC   1838714 . PMID   17108083.
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (August 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" (PDF). Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID   15324660. S2CID   2371325.
• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID   7566098.