SKIV2L2

MTREX
Identifiers
Aliases	MTREX , Dob1, KIAA0052, Mtr4, fSAP118, Ski2 like RNA helicase 2, Mtr4 exosome RNA helicase, SKIV2L2
External IDs	OMIM: 618122 MGI: 1919448 HomoloGene: 6257 GeneCards: MTREX
Gene location (Human)
Chr.	Chromosome 5 (human)
End	55,425,579 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	113,063,932 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; sural nerve; ; Ganglionic eminence; ; jejunal mucosa; ; islet of Langerhans; ; biceps brachii; ; right ventricle; ; deltoid muscle; ; duodenum; ; thymus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA helicase activity ; nucleotide binding ; GO:0001948 protein binding ; ATP binding ; hydrolase activity ; GO:0008026 helicase activity ; nucleic acid binding ; RNA binding ;
Cellular component	catalytic step 2 spliceosome ; spliceosomal complex ; nucleolus ; exosome (RNase complex) ; nucleus ; nucleoplasm ; nuclear exosome (RNase complex) ; TRAMP complex ;
Biological process	mRNA processing ; maturation of 5.8S rRNA ; RNA splicing ; rRNA processing ; mRNA splicing, via spliceosome ; RNA catabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	23517
	72198
	ENSG00000039123
	ENSMUSG00000016018
	P42285
	Q9CZU3
	NM_015360
	NM_028151
	NP_056175
	NP_082427
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated June 16, 2022

Superkiller viralicidic activity 2-like 2 is a protein that in humans is encoded by the SKIV2L2 gene.^[5]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000039123 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000016018 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)".

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Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome". J. Biol. Chem. 276 (9): 6177–84. doi: 10.1074/jbc.M007603200 . PMID 11110791.
Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi: 10.1016/S0092-8674(01)00578-5 . PMID 11719186. S2CID 14817671.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi: 10.1016/S0960-9822(01)00650-9 . PMID 11790298. S2CID 14132033.
Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. PMID 11812149.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266 . PMID 11991638.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617 . PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Lin Z, Crockett DK, Lim MS, Elenitoba-Johnson KS (2004). "High-throughput analysis of protein/peptide complexes by immunoprecipitation and automated LC-MS/MS". J Biomol Tech. 14 (2): 149–55. PMC 2279905 . PMID 14676314.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147 . PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Nagahama M, Yamazoe T, Hara Y, et al. (2006). "The AAA-ATPase NVL2 is a component of pre-ribosomal particles that interacts with the DExD/H-box RNA helicase DOB1". Biochem. Biophys. Res. Commun. 346 (3): 1075–82. doi:10.1016/j.bbrc.2006.06.017. PMID 16782053.
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Schilders G, van Dijk E, Pruijn GJ (2007). "C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing". Nucleic Acids Res. 35 (8): 2564–72. doi:10.1093/nar/gkm082. PMC 1885644 . PMID 17412707.
Yang CT, Hindes AE, Hultman KA, Johnson SL (2007). "Mutations in gfpt1 and skiv2l2 cause distinct stage-specific defects in larval melanocyte regeneration in zebrafish". PLOS Genet. 3 (6): e88. doi:10.1371/journal.pgen.0030088. PMC 1885281 . PMID 17542649.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000039123 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000016018 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)".

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SKIV2L2

Related Research Articles

References

Further reading