SLAMF6

SLAMF6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IF7
Identifiers
Aliases	SLAMF6 , CD352, KALI, KALIb, Ly108, NTB-A, NTBA, SF2000, SLAM family member 6
External IDs	OMIM: 606446; MGI: 1353620; HomoloGene: 49945; GeneCards: SLAMF6; OMA:SLAMF6 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q23.2-q23.3 Start 160,485,030 bp [1] End 160,523,262 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 H3|1 79.54 cM Start 171,745,082 bp [2] End 171,780,737 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte lymph node spleen appendix blood bone marrow cells superficial temporal artery gallbladder mucosa of transverse colon rectum Top expressed in thymus spleen lymph node blood mesenteric lymph nodes gastrula granulocyte submandibular gland subcutaneous adipose tissue embryo More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component integral component of membrane plasma membrane extracellular exosome membrane Biological process natural killer cell proliferation immune system process positive regulation of interferon-gamma production positive regulation of interleukin-17 production innate immune response positive regulation of natural killer cell mediated cytotoxicity adaptive immune response T-helper 17 cell lineage commitment regulation of immune response natural killer cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114836 30925 Ensembl ENSG00000162739 ENSMUSG00000015314 UniProt Q96DU3 Q9ET39 RefSeq (mRNA) NM_052931 NM_001184714 NM_001184715 NM_001184716 NM_030710 NM_001347186 NM_001347187 RefSeq (protein) NP_001171643 NP_001171644 NP_001171645 NP_443163 NP_001334115 NP_001334116 NP_109635 Location (UCSC) Chr 1: 160.49 – 160.52 Mb Chr 1: 171.75 – 171.78 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SLAM family member 6 is a protein that in humans is encoded by the SLAMF6 gene. ^{[5] [6]}

The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000162739 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015314 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bottino C, Falco M, Parolini S, Marcenaro E, Augugliaro R, Sivori S, Landi E, Biassoni R, Notarangelo LD, Moretta L, Moretta A (Aug 2001). "NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease". J Exp Med. 194 (3): 235–46. doi:10.1084/jem.194.3.235. PMC   2193462 . PMID   11489943.
6. "Entrez Gene: SLAMF6 SLAM family member 6".

Further reading

• Claus M, Meinke S, Bhat R, Watzl C (2007). "Regulation of NK cell activity by 2B4, NTB-A and CRACC". Front. Biosci. 13 (13): 956–65. doi: 10.2741/2735 . PMID   17981603.
• Hercend T, Meuer S, Brennan A, et al. (1984). "Natural killer-like function of activated T lymphocytes: differential blocking effects of monoclonal antibodies specific for a 90-kDa clonotypic structure". Cell. Immunol. 86 (2): 381–92. doi:10.1016/0008-8749(84)90393-9. PMID   6610481.
• Kong G, Dalton M, Wardenburg JB, et al. (1996). "Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function". Mol. Cell. Biol. 16 (9): 5026–35. doi:10.1128/MCB.16.9.5026. PMC   231504 . PMID   8756661.
• Lee YJ, Luisiri P, Clark MR (1996). "A novel complex, p40/42, is constitutively associated with the B cell antigen receptor and phosphorylated upon receptor stimulation". J. Immunol. 157 (9): 3828–37. doi:10.4049/jimmunol.157.9.3828. PMID   8892612.
• Gray CW, Ward RV, Karran E, et al. (2000). "Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response". Eur. J. Biochem. 267 (18): 5699–710. doi: 10.1046/j.1432-1327.2000.01589.x . PMID   10971580.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Del Valle JM, Engel P, Martín M (2003). "The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2)". J. Biol. Chem. 278 (19): 17430–7. doi: 10.1074/jbc.M301569200 . PMID   12621057.
• Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC (2003). "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation". J. Immunol. 171 (5): 2485–95. doi: 10.4049/jimmunol.171.5.2485 . PMID   12928397.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Valdez PA, Wang H, Seshasayee D, et al. (2004). "NTB-A, a new activating receptor in T cells that regulates autoimmune disease". J. Biol. Chem. 279 (18): 18662–9. doi: 10.1074/jbc.M312313200 . PMID   14988414.
• Flaig RM, Stark S, Watzl C (2004). "Cutting edge: NTB-A activates NK cells via homophilic interaction". J. Immunol. 172 (11): 6524–7. doi:10.4049/jimmunol.172.11.6524. PMID   15153464. S2CID   38642218.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Stark S, Watzl C (2006). "2B4 (CD244), NTB-A and CRACC (CS1) stimulate cytotoxicity but no proliferation in human NK cells". Int. Immunol. 18 (2): 241–7. doi: 10.1093/intimm/dxh358 . PMID   16410313.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Eissmann P, Watzl C (2006). "Molecular analysis of NTB-A signaling: a role for EAT-2 in NTB-A-mediated activation of human NK cells". J. Immunol. 177 (5): 3170–7. doi: 10.4049/jimmunol.177.5.3170 . PMID   16920955.
• Cao E, Ramagopal UA, Fedorov A, et al. (2006). "NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family". Immunity. 25 (4): 559–70. doi: 10.1016/j.immuni.2006.06.020 . PMID   17045824.
• Banerjee P, Feuer G, Barker E (2007). "Human T-cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and -2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary CD4+ T cells from autologous natural killer cell-mediated cytotoxicity despite the reduction of major histocompatibility complex class I molecules on infected cells". J. Virol. 81 (18): 9707–17. doi:10.1128/JVI.00887-07. PMC   2045425 . PMID   17609265.