SLAMF8

SLAMF8
Identifiers
Aliases	SLAMF8 , BLAME, CD353, SBBI42, SLAM family member 8
External IDs	OMIM: 606620; MGI: 1921998; HomoloGene: 10589; GeneCards: SLAMF8; OMA:SLAMF8 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q23.2 Start 159,826,811 bp [1] End 159,837,492 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 H3 Start 172,409,325 bp [2] End 172,418,135 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in appendix lymph node testicle lower lobe of lung decidua spleen superficial temporal artery amniotic fluid gallbladder rectum Top expressed in mesenteric lymph nodes embryo spleen lumbar subsegment of spinal cord morula granulocyte right kidney blastocyst thymus subcutaneous adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor activity identical protein binding Cellular component membrane integral component of membrane cell surface Biological process leukocyte chemotaxis involved in inflammatory response B-1 B cell lineage commitment negative regulation of macrophage chemotaxis regulation of NAD(P)H oxidase activity defense response to bacterium regulation of kinase activity regulation of B cell differentiation negative regulation of respiratory burst involved in inflammatory response negative regulation of monocyte chemotaxis phagosome acidification negative regulation of neutrophil migration negative regulation of dendritic cell chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56833 74748 Ensembl ENSG00000158714 ENSMUSG00000053318 UniProt Q9P0V8 Q9D3G2 RefSeq (mRNA) NM_020125 NM_001330741 NM_029084 RefSeq (protein) NP_001317670 NP_064510 NP_083360 Location (UCSC) Chr 1: 159.83 – 159.84 Mb Chr 1: 172.41 – 172.42 Mb PubMed search [3] [4]
Wikidata
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SLAM family member 8 is a protein that in humans is encoded by the SLAMF8 gene. ^{[5] [6]}

Function

This gene encodes a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteins are characterized by Ig domains. This protein is expressed in lymphoid tissues, and studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. The gene is found in a region of chromosome 1 containing many CD2 genes. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000158714 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053318 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kingsbury GA, Feeney LA, Nong Y, Calandra SA, Murphy CJ, Corcoran JM, Wang Y, Prabhu Das MR, Busfield SJ, Fraser CC, Villeval JL (May 2001). "Cloning, expression, and function of BLAME, a novel member of the CD2 family". Journal of Immunology. 166 (9): 5675–80. doi: 10.4049/jimmunol.166.9.5675 . PMID   11313408.
6. "Entrez Gene: SLAMF8 SLAM family member 8".

Further reading

• Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC (September 2003). "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation". Journal of Immunology. 171 (5): 2485–95. doi: 10.4049/jimmunol.171.5.2485 . PMID   12928397.
• Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.