SLFN11

SLFN11
Identifiers
Aliases	SLFN11 , SLFN8/9, schlafen family member 11
External IDs	OMIM: 614953; MGI: 2672859; HomoloGene: 89175; GeneCards: SLFN11; OMA:SLFN11 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q12 Start 35,350,305 bp [1] End 35,373,701 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 C Start 82,892,984 bp [2] End 82,911,636 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte Achilles tendon sural nerve bone marrow cells right lobe of thyroid gland left uterine tube left lobe of thyroid gland granulocyte appendix upper lobe of left lung Top expressed in spleen granulocyte thymus bone marrow embryo ovary embryo zone of skin jejunum liver More reference expression data BioGPS n/a
Gene ontology Molecular function tRNA binding nucleotide binding ATP binding RNA binding protein binding ATPase activity helicase activity hydrolase activity Cellular component aggresome nucleus nucleoplasm cytosol site of DNA damage chromosome Biological process negative regulation of G1/S transition of mitotic cell cycle defense response to virus immune system process negative regulation of DNA replication positive regulation of cell death replication fork arrest cellular response to DNA damage stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 91607 276950 Ensembl ENSG00000172716 ENSMUSG00000035208 UniProt Q7Z7L1 B1ARD8 RefSeq (mRNA) NM_001104587 NM_001104588 NM_001104589 NM_001104590 NM_152270 NM_001376007 NM_001376008 NM_001376009 NM_001376010 NM_001376011 NM_001376012 NM_001387158 NM_001387159 NM_001387160 NM_001387161 NM_001387162 NM_001387163 NM_001167743 NM_181545 RefSeq (protein) NP_001098057 NP_001098058 NP_001098059 NP_001098060 NP_689483 NP_001362936 NP_001362937 NP_001362938 NP_001362939 NP_001362940 NP_001362941 NP_001161215 NP_853523 Location (UCSC) Chr 17: 35.35 – 35.37 Mb Chr 11: 82.89 – 82.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Schlafen family member 11 is a protein that in humans is encoded by the SLFN11 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000172716 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035208 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
6. "Entrez Gene: SLFN11 schlafen family member 11".

Further reading

• Schwarz DA, Katayama CD, Hedrick SM (1998). "Schlafen, a new family of growth regulatory genes that affect thymocyte development". Immunity. 9 (5): 657–68. doi: 10.1016/S1074-7613(00)80663-9 . PMID   9846487.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.