SLITRK5

SLITRK5
Identifiers
Aliases	SLITRK5 , LRRC11, bA364G4.2, SLIT and NTRK like family member 5
External IDs	OMIM: 609680; MGI: 2679448; HomoloGene: 9193; GeneCards: SLITRK5; OMA:SLITRK5 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q31.2 Start 87,671,371 bp [1] End 87,696,272 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 E4 Start 111,912,529 bp [2] End 111,920,573 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus frontal pole Brodmann area 23 parotid gland Brodmann area 10 orbitofrontal cortex Brodmann area 46 postcentral gyrus superior frontal gyrus Region I of hippocampus proper Top expressed in subiculum primary motor cortex anterior amygdaloid area ventromedial nucleus piriform cortex mammillary body cingulate gyrus facial motor nucleus superior colliculus olfactory tubercle More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 26050 75409 Ensembl ENSG00000165300 ENSMUSG00000033214 UniProt O94991 Q810B7 RefSeq (mRNA) NM_015567 NM_001384609 NM_001384610 NM_029273 NM_198865 NM_001378768 NM_001378769 NM_001378770 RefSeq (protein) NP_056382 NP_942565 NP_001365697 NP_001365698 NP_001365699 Location (UCSC) Chr 13: 87.67 – 87.7 Mb Chr 14: 111.91 – 111.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SLIT and NTRK-like protein 5 is a protein that in humans is encoded by the SLITRK5 gene. ^{[5] [6] [7]}

Function

Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003).[supplied by OMIM] ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000165300 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033214 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (December 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi: 10.1093/dnares/5.6.355 . PMID   10048485.
6. Aruga J, Yokota N, Mikoshiba K (October 2003). "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue". Gene. 315: 87–94. doi:10.1016/S0378-1119(03)00715-7. PMID   14557068.
7. "Entrez Gene: SLITRK5 SLIT and NTRK-like family, member 5".

Further reading

• Amanchy R, Kalume DE, Iwahori A, Zhong J, Pandey A (2006). "Phosphoproteome analysis of HeLa cells using stable isotope labeling with amino acids in cell culture (SILAC)". Journal of Proteome Research. 4 (5): 1661–71. doi:10.1021/pr050134h. PMID   16212419.
• Aruga J, Mikoshiba K (September 2003). "Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth". Molecular and Cellular Neurosciences. 24 (1): 117–29. doi:10.1016/S1044-7431(03)00129-5. PMID   14550773. S2CID   25473221.