SLITRK5

SLITRK5
Identifiers
Aliases	SLITRK5 , LRRC11, bA364G4.2, SLIT and NTRK like family member 5
External IDs	OMIM: 609680 MGI: 2679448 HomoloGene: 9193 GeneCards: SLITRK5
Gene location (Human)
Chr.	Chromosome 13 (human)
End	87,696,272 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	111,920,573 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; frontal pole; ; Brodmann area 23; ; parotid gland; ; Brodmann area 10; ; orbitofrontal cortex; ; Brodmann area 46; ; postcentral gyrus; ; superior frontal gyrus; ; Region I of hippocampus proper;
	Top expressed in
	subiculum; ; primary motor cortex; ; ventromedial nucleus; ; piriform cortex; ; mammillary body; ; cingulate gyrus; ; facial motor nucleus; ; superior colliculus; ; olfactory tubercle; ; supraoptic nucleus;
	More reference expression data
	More reference expression data
Orthologs
	26050
	75409
	ENSG00000165300
	ENSMUSG00000033214
	O94991
	Q810B7
	NM_015567 ; NM_001384609 ; NM_001384610
	NM_029273 ; NM_198865 ; NM_001378768 ; NM_001378769 ; NM_001378770 Contents Function ; References ; Further reading ;
	NP_056382
	NP_942565 ; NP_001365697 ; NP_001365698 ; NP_001365699
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 05, 2022

SLIT and NTRK-like protein 5 is a protein that in humans is encoded by the SLITRK5 gene.^[5]^[6]^[7]

Function

Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003).[supplied by OMIM]^[7]

Related Research Articles

SLITRK1 is a human gene that codes for a transmembrane and signalling protein that is part of the SLITRK gene family, which is responsible for synapse regulation and presynaptic differentiation in the brain. Expression of the gene has been linked to early formation of excitatory synapses through binding with receptor tyrosine phosphatase PTP (LAR-RPTP). Various studies over the years have linked mutations in the gene to conditions on the OCD spectrum, Tourette syndrome and trichotillomania, however the mutations in the genome itself vary greatly between individuals, with most mutations observed being hard to find in repeat studies.

Pleiotrophin (PTN) also known as heparin-binding brain mitogen (HBBM) or heparin-binding growth factor 8 (HBGF-8) or neurite growth-promoting factor 1 (NEGF1) or heparin affinity regulatory peptide (HARP) or heparin binding growth associated molecule (HB-GAM) is a protein that in humans is encoded by the PTN gene. Pleiotrophin is an 18-kDa growth factor that has a high affinity for heparin. It is structurally related to midkine and retinoic acid induced heparin-binding protein.

Brain-specific angiogenesis inhibitor 3 is a protein that in humans is encoded by the BAI3 gene.

Latrophilin 2 is a protein that in humans is encoded by the ADGRL2 gene.

Synaptotagmin-2 is a protein that in humans is encoded by the SYT2 gene.

Brain mitochondrial carrier protein 1 is a protein that in humans is encoded by the SLC25A14 gene.

Cell adhesion molecule 3 is a protein that in humans is encoded by the CADM3 gene.

Protein phosphatase Slingshot homolog 2 is an enzyme that in humans is encoded by the SSH2 gene.

Paraneoplastic antigen Ma2 is a protein that in humans is encoded by the PNMA2 gene.

Rab3 GTPase-activating protein non-catalytic subunit is an enzyme that in humans is encoded by the RAB3GAP2 gene.

PHD finger protein 21A is a protein that in humans is encoded by the PHF21A gene.

Growth arrest-specific protein 7 is a protein that in humans is encoded by the GAS7 gene.

Ras GTPase-activating protein 4 is an enzyme that in humans is encoded by the RASA4 gene.

Connector enhancer of kinase suppressor of ras 2, also known as CNK homolog protein 2 (CNK2) or maguin, is an enzyme that in humans is encoded by the CNKSR2 gene.

Zinc fingers and homeoboxes protein 2 is a protein that in humans is encoded by the ZHX2 gene.

Ubiquitin-conjugating enzyme E2 O is a protein that in humans is encoded by the UBE2O gene.

SLIT and NTRK-like protein 6 is a protein that in humans is encoded by the SLITRK6 gene.

SLIT and NTRK-like protein 2 is a protein that in humans is encoded by the SLITRK2 gene.

Brain acid soluble protein 1 is a protein that in humans is encoded by the BASP1 gene.

ZIC5 is a member of the Zinc finger of the cerebellum (ZIC) protein family. ZIC5 is located on chromosome 13 in a divergently transcribed gene pair with the closely related gene ZIC2. It has been suggested that this tandem arrangement allows ZIC2 and ZIC5 to share regulatory elements and causes the two genes to have very similar expression patterns.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000165300 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033214 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (December 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi: 10.1093/dnares/5.6.355 . PMID 10048485.
↑ Aruga J, Yokota N, Mikoshiba K (October 2003). "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue". Gene. 315: 87–94. doi:10.1016/S0378-1119(03)00715-7. PMID 14557068.
1 2 "Entrez Gene: SLITRK5 SLIT and NTRK-like family, member 5".

SLITRK5

Contents

Function

Related Research Articles

References

Further reading