SLU7

SLU7
Identifiers
Aliases	SLU7 , 9G8, hSlu7, SLU7 homolog, splicing factor
External IDs	OMIM: 605974; MGI: 2385598; HomoloGene: 4690; GeneCards: SLU7; OMA:SLU7 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q33.3 Start 160,401,641 bp [1] End 160,421,711 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B1.1 Start 43,324,571 bp [2] End 43,338,808 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle Achilles tendon colon superior frontal gyrus sural nerve prefrontal cortex islet of Langerhans Top expressed in saccule otic vesicle otic placode genital tubercle granulocyte zygote deep cerebellar nuclei facial motor nucleus vestibular sensory epithelium ventricular zone More reference expression data BioGPS n/a
Gene ontology Molecular function pre-mRNA 3'-splice site binding second spliceosomal transesterification activity metal ion binding protein binding nucleic acid binding zinc ion binding Cellular component cytoplasm nuclear speck catalytic step 2 spliceosome membrane intracellular membrane-bounded organelle small nuclear ribonucleoprotein complex spliceosomal complex nucleus nucleoplasm cytosol Biological process cellular response to heat RNA splicing, via transesterification reactions mRNA processing mRNA 3'-splice site recognition RNA splicing intracellular protein transport alternative mRNA splicing, via spliceosome RNA export from nucleus mRNA splicing, via spliceosome mRNA export from nucleus mRNA 3'-end processing termination of RNA polymerase II transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10569 193116 Ensembl ENSG00000164609 ENSMUSG00000020409 UniProt O95391 Q8BHJ9 RefSeq (mRNA) NM_006425 NM_148673 NM_198936 RefSeq (protein) NP_006416 NP_001351446 NP_001351447 NP_001351449 NP_001351450 NP_001351451 NP_001351452 NP_683514 NP_945174 Location (UCSC) Chr 5: 160.4 – 160.42 Mb Chr 11: 43.32 – 43.34 Mb PubMed search [3] [4]
Wikidata
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Pre-mRNA-splicing factor SLU7 is a protein that in humans is encoded by the SLU7 gene. ^{[5] [6] [7]}

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000164609 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020409 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chua K, Reed R (May 1999). "Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing". Genes Dev. 13 (7): 841–50. doi:10.1101/gad.13.7.841. PMC   316594 . PMID   10197984.
6. Shomron N, Alberstein M, Reznik M, Ast G (Mar 2005). "Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing". J Cell Sci. 118 (Pt 6): 1151–9. doi:10.1242/jcs.01720. PMID   15728250. S2CID   18873022.
7. "Entrez Gene: SLU7 SLU7 splicing factor homolog (S. cerevisiae)".

Further reading

• Alberstein M, Amit M, Vaknin K, et al. (2008). "Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing". RNA. 13 (11): 1988–99. doi:10.1261/rna.492907. PMC   2040095 . PMID   17804646.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Shomron N, Reznik M, Ast G (2005). "Splicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleus". Mol. Biol. Cell. 15 (8): 3782–95. doi:10.1091/mbc.E04-02-0152. PMC   491837 . PMID   15181151.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Chua K, Reed R (2001). "An upstream AG determines whether a downstream AG is selected during catalytic step II of splicing". Mol. Cell. Biol. 21 (5): 1509–14. doi:10.1128/MCB.21.5.1509-1514.2001. PMC   86697 . PMID   11238888.
• Chua K, Reed R (2000). "The RNA splicing factor hSlu7 is required for correct 3' splice-site choice". Nature. 402 (6758): 207–10. doi:10.1038/46086. PMID   10647016. S2CID   4428185.