SMARCD1

SMARCD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UHR
Identifiers
Aliases	SMARCD1 , BAF60A, CRACD1, Rsc6p, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1, CSS11
External IDs	OMIM: 601735; MGI: 1933623; HomoloGene: 20670; GeneCards: SMARCD1; OMA:SMARCD1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q13.12 Start 50,085,200 bp [1] End 50,100,707 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15 F1|15 56.13 cM Start 99,600,010 bp [2] End 99,611,872 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone right lobe of thyroid gland left lobe of thyroid gland right ovary cardia right hemisphere of cerebellum body of uterus left ovary granulocyte Top expressed in superior frontal gyrus ventricular zone epiblast primary visual cortex tail of embryo neural tube dentate gyrus of hippocampal formation granule cell genital tubercle olfactory tubercle entorhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function molecular adaptor activity transcription coactivator activity chromatin binding protein binding signaling receptor binding Cellular component npBAF complex nBAF complex nucleus nucleoplasm intracellular membrane-bounded organelle SWI/SNF complex Biological process regulation of transcription by RNA polymerase II chromatin remodeling nucleosome disassembly cellular response to fatty acid nervous system development chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6602 83797 Ensembl ENSG00000066117 ENSMUSG00000023018 UniProt Q96GM5 Q61466 RefSeq (mRNA) NM_003076 NM_139071 NM_031842 RefSeq (protein) NP_003067 NP_620710 NP_114030 Location (UCSC) Chr 12: 50.09 – 50.1 Mb Chr 15: 99.6 – 99.61 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 is a protein that in humans is encoded by the SMARCD1 gene. ^{[5] [6] [7] [8]}

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Two transcript variants encoding different isoforms have been found for this gene. ^[8]

Interactions

SMARCD1 has been shown to interact with Glucocorticoid receptor. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000066117 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023018 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR (Nov 1996). "Diversity and specialization of mammalian SWI/SNF complexes". Genes Dev. 10 (17): 2117–30. doi: 10.1101/gad.10.17.2117 . PMID   8804307.
6. Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U (Sep 1998). "Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome". Genomics. 51 (1): 140–3. doi: 10.1006/geno.1998.5343 . PMID   9693044.
7. Hsiao PW, Fryer CJ, Trotter KW, Wang W, Archer TK (Aug 2003). "BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation". Mol Cell Biol. 23 (17): 6210–20. doi:10.1128/MCB.23.17.6210-6220.2003. PMC   180928 . PMID   12917342.
8. "Entrez Gene: SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1".

Further reading

• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi: 10.1101/gr.6.9.807 . PMID   8889549.
• Wang W, Côté J, Xue Y, et al. (1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". EMBO J. 15 (19): 5370–82. doi:10.1002/j.1460-2075.1996.tb00921.x. PMC   452280 . PMID   8895581.
• Cho H, Orphanides G, Sun X, et al. (1998). "A human RNA polymerase II complex containing factors that modify chromatin structure". Mol. Cell. Biol. 18 (9): 5355–63. doi:10.1128/MCB.18.9.5355. PMC   109120 . PMID   9710619.
• O'Neill D, Yang J, Erdjument-Bromage H, et al. (1999). "Tissue-specific and developmental stage-specific DNA binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching". Proc. Natl. Acad. Sci. U.S.A. 96 (2): 349–54. Bibcode:1999PNAS...96..349O. doi: 10.1073/pnas.96.2.349 . PMC   15139 . PMID   9892636.
• Phelan ML, Sif S, Narlikar GJ, Kingston RE (1999). "Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits". Mol. Cell. 3 (2): 247–53. doi: 10.1016/S1097-2765(00)80315-9 . PMID   10078207.
• Ito T, Yamauchi M, Nishina M, et al. (2001). "Identification of SWI.SNF complex subunit BAF60a as a determinant of the transactivation potential of Fos/Jun dimers". J. Biol. Chem. 276 (4): 2852–7. doi: 10.1074/jbc.M009633200 . PMID   11053448.
• Xue Y, Canman JC, Lee CS, et al. (2001). "The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes". Proc. Natl. Acad. Sci. U.S.A. 97 (24): 13015–20. Bibcode:2000PNAS...9713015X. doi: 10.1073/pnas.240208597 . PMC   27170 . PMID   11078522.
• Kato H, Tjernberg A, Zhang W, et al. (2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". J. Biol. Chem. 277 (7): 5498–505. doi: 10.1074/jbc.M108702200 . hdl: 2066/170683 . PMID   11734557.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Nie Z, Yan Z, Chen EH, et al. (2003). "Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner". Mol. Cell. Biol. 23 (8): 2942–52. doi:10.1128/MCB.23.8.2942-2952.2003. PMC   152562 . PMID   12665591.
• Chien CY, Liu WK, Chou CK, Su JY (2003). "The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation". FEBS Lett. 543 (1–3): 55–60. doi: 10.1016/S0014-5793(03)00401-0 . PMID   12753905. S2CID   31400521.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Assmann EM, Alborghetti MR, Camargo ME, Kobarg J (2006). "FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region". J. Biol. Chem. 281 (15): 9869–81. doi: 10.1074/jbc.M513280200 . PMID   16484223.