SMARCD1

SMARCD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UHR
Identifiers
Aliases	SMARCD1 , BAF60A, CRACD1, Rsc6p, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1, CSS11
External IDs	OMIM: 601735 MGI: 1933623 HomoloGene: 20670 GeneCards: SMARCD1
Gene location (Human)
Chr.	Chromosome 12 (human)
End	50,100,707 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	99,611,872 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; cardia; ; gastric mucosa; ; minor salivary gland; ; tibial nerve; ; lymph node; ; anterior pituitary; ; left adrenal gland;
	Top expressed in
	superior frontal gyrus; ; neural tube; ; olfactory tubercle; ; entorhinal cortex; ; ganglionic eminence; ; yolk sac; ; somite; ; olfactory bulb; ; cerebellar cortex; ; thymus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	molecular adaptor activity ; transcription coactivator activity ; chromatin binding ; protein binding ; signaling receptor binding ;
Cellular component	npBAF complex ; nBAF complex ; nucleus ; nucleoplasm ; intracellular membrane-bounded organelle ; SWI/SNF complex ;
Biological process	regulation of transcription by RNA polymerase II ; chromatin remodeling ; nucleosome disassembly ; cellular response to fatty acid ; nervous system development ; chromatin organization ;
	Sources:Amigo / QuickGO
Orthologs
	6602
	83797
	ENSG00000066117
	ENSMUSG00000023018
	Q96GM5
	Q61466
	NM_003076 ; NM_139071
	NM_031842
	NP_003067 ; NP_620710
	NP_114030
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 13, 2023

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 is a protein that in humans is encoded by the SMARCD1 gene.^[5]^[6]^[7]^[8]

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Two transcript variants encoding different isoforms have been found for this gene.^[8]

Interactions

SMARCD1 has been shown to interact with Glucocorticoid receptor.^[7]

Related Research Articles

In molecular biology, SWI/SNF, is a subfamily of ATP-dependent chromatin remodeling complexes, which is found in eukaryotes. In other words, it is a group of proteins that associate to remodel the way DNA is packaged. This complex is composed of several proteins – products of the SWI and SNF genes, as well as other polypeptides. It possesses a DNA-stimulated ATPase activity that can destabilize histone-DNA interactions in reconstituted nucleosomes in an ATP-dependent manner, though the exact nature of this structural change is unknown. The SWI/SNF subfamily provides crucial nucleosome rearrangement, which is seen as ejection and/or sliding. The movement of nucleosomes provides easier access to the chromatin, allowing genes to be activated or repressed.

Transcription activator BRG1 also known as ATP-dependent chromatin remodeler SMARCA4 is a protein that in humans is encoded by the SMARCA4 gene.

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 is a protein that in humans is encoded by the SMARCB1 gene.

Probable global transcription activator SNF2L2 is a protein that in humans is encoded by the SMARCA2 gene.

Actin-like protein 6A is a protein that in humans is encoded by the ACTL6A gene.

AT-rich interactive domain-containing protein 1A is a protein that in humans is encoded by the ARID1A gene.

SWI/SNF complex subunit SMARCC1 is a protein that in humans is encoded by the SMARCC1 gene.

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 is a protein that in humans is encoded by the SMARCE1 gene.

SWI/SNF complex subunit SMARCC2 is a protein that in humans is encoded by the SMARCC2 gene.

AT-rich interactive domain-containing protein 1B is a protein that in humans is encoded by the ARID1B gene. ARID1B is a component of the human SWI/SNF chromatin remodeling complex.

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 is a protein that in humans is encoded by the SMARCAD1 gene.

Myosin-Ic is a protein that in humans is encoded by the MYO1C gene.

Protein polybromo-1 (PB1) also known as BRG1-associated factor 180 (BAF180) is a protein that in humans is encoded by the PBRM1 gene.

Helicase SRCAP is an enzyme that in humans is encoded by the SRCAP gene.

Remodeling and spacing factor 1 is a protein that in humans is encoded by the RSF1 gene.

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 is a protein that in humans is encoded by the SMARCD3 gene.

Probable global transcription activator SNF2L1 is a protein that in humans is encoded by the SMARCA1 gene.

DNA-directed RNA polymerase I subunit RPA1 is an enzyme that in humans is encoded by the POLR1A gene.

Actin-like protein 6B is a protein that in humans is encoded by the ACTL6B gene.

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 is a protein that in humans is encoded by the SMARCD2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000066117 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023018 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR (Nov 1996). "Diversity and specialization of mammalian SWI/SNF complexes". Genes Dev. 10 (17): 2117–30. doi: 10.1101/gad.10.17.2117 . PMID 8804307.
↑ Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U (Sep 1998). "Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome". Genomics. 51 (1): 140–3. doi: 10.1006/geno.1998.5343 . PMID 9693044.
1 2 Hsiao PW, Fryer CJ, Trotter KW, Wang W, Archer TK (Aug 2003). "BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation". Mol Cell Biol. 23 (17): 6210–20. doi:10.1128/MCB.23.17.6210-6220.2003. PMC 180928 . PMID 12917342.
1 2 "Entrez Gene: SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1".

Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi: 10.1101/gr.6.9.807 . PMID 8889549.
Wang W, Côté J, Xue Y, et al. (1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". EMBO J. 15 (19): 5370–82. doi:10.1002/j.1460-2075.1996.tb00921.x. PMC 452280 . PMID 8895581.
Cho H, Orphanides G, Sun X, et al. (1998). "A human RNA polymerase II complex containing factors that modify chromatin structure". Mol. Cell. Biol. 18 (9): 5355–63. doi:10.1128/MCB.18.9.5355. PMC 109120 . PMID 9710619.
O'Neill D, Yang J, Erdjument-Bromage H, et al. (1999). "Tissue-specific and developmental stage-specific DNA binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching". Proc. Natl. Acad. Sci. U.S.A. 96 (2): 349–54. Bibcode:1999PNAS...96..349O. doi: 10.1073/pnas.96.2.349 . PMC 15139 . PMID 9892636.
Phelan ML, Sif S, Narlikar GJ, Kingston RE (1999). "Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits". Mol. Cell. 3 (2): 247–53. doi: 10.1016/S1097-2765(00)80315-9 . PMID 10078207.
Ito T, Yamauchi M, Nishina M, et al. (2001). "Identification of SWI.SNF complex subunit BAF60a as a determinant of the transactivation potential of Fos/Jun dimers". J. Biol. Chem. 276 (4): 2852–7. doi: 10.1074/jbc.M009633200 . PMID 11053448.
Xue Y, Canman JC, Lee CS, et al. (2001). "The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes". Proc. Natl. Acad. Sci. U.S.A. 97 (24): 13015–20. Bibcode:2000PNAS...9713015X. doi: 10.1073/pnas.240208597 . PMC 27170 . PMID 11078522.
Kato H, Tjernberg A, Zhang W, et al. (2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". J. Biol. Chem. 277 (7): 5498–505. doi: 10.1074/jbc.M108702200 . PMID 11734557.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Nie Z, Yan Z, Chen EH, et al. (2003). "Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner". Mol. Cell. Biol. 23 (8): 2942–52. doi:10.1128/MCB.23.8.2942-2952.2003. PMC 152562 . PMID 12665591.
Chien CY, Liu WK, Chou CK, Su JY (2003). "The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation". FEBS Lett. 543 (1–3): 55–60. doi: 10.1016/S0014-5793(03)00401-0 . PMID 12753905. S2CID 31400521.
Kitagawa H, Fujiki R, Yoshimura K, et al. (2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell. 113 (7): 905–17. doi: 10.1016/S0092-8674(03)00436-7 . PMID 12837248.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Assmann EM, Alborghetti MR, Camargo ME, Kobarg J (2006). "FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region". J. Biol. Chem. 281 (15): 9869–81. doi: 10.1074/jbc.M513280200 . PMID 16484223.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000066117 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023018 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8804307-5] Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR (Nov 1996). "Diversity and specialization of mammalian SWI/SNF complexes". Genes Dev. 10 (17): 2117–30. doi: 10.1101/gad.10.17.2117 . PMID 8804307.

[pmid9693044-6] Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U (Sep 1998). "Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome". Genomics. 51 (1): 140–3. doi: 10.1006/geno.1998.5343 . PMID 9693044.

[pmid12917342-7] 1 2 Hsiao PW, Fryer CJ, Trotter KW, Wang W, Archer TK (Aug 2003). "BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation". Mol Cell Biol. 23 (17): 6210–20. doi:10.1128/MCB.23.17.6210-6220.2003. PMC 180928 . PMID 12917342.

[entrez-8] 1 2 "Entrez Gene: SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1".

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SMARCD1

Contents

Interactions

Related Research Articles

References

Further reading