Neutral Sphingomyelinase2 is an enzyme that in humans is encoded by the SMPD3 gene. [5] [6]
Neutral Sphingomyelinase2 is an enzyme that in humans is encoded by the SMPD3 gene. [5] [6]
Lipid signaling, broadly defined, refers to any biological cell signaling event involving a lipid messenger that binds a protein target, such as a receptor, kinase or phosphatase, which in turn mediate the effects of these lipids on specific cellular responses. Lipid signaling is thought to be qualitatively different from other classical signaling paradigms because lipids can freely diffuse through membranes. One consequence of this is that lipid messengers cannot be stored in vesicles prior to release and so are often biosynthesized "on demand" at their intended site of action. As such, many lipid signaling molecules cannot circulate freely in solution but, rather, exist bound to special carrier proteins in serum.
Sphingomyelin phosphodiesterase is a hydrolase enzyme that is involved in sphingolipid metabolism reactions. SMase is a member of the DNase I superfamily of enzymes and is responsible for breaking sphingomyelin (SM) down into phosphocholine and ceramide. The activation of SMase has been suggested as a major route for the production of ceramide in response to cellular stresses.
Death receptor 4 (DR4), also known as TRAIL receptor 1 (TRAILR1) and tumor necrosis factor receptor superfamily member 10A (TNFRSF10A), is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis.
NADPH oxidase 4 is an enzyme that in humans is encoded by the NOX4 gene, and is a member of the NOX family of NADPH oxidases.
P2Y purinoceptor 4 is a protein that in humans is encoded by the P2RY4 gene.
PITSLRE serine/threonine-protein kinase CDC2L1 is an enzyme that in humans is encoded by the CDK11B gene.
Cytoplasmic tyrosine-protein kinase BMX is an enzyme that in humans is encoded by the BMX gene.
Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 is a protein that in humans is encoded by the AIMP1 gene.
TNF receptor-associated factor 4 (TRAF4) also known as RING finger protein 83 (RNF83) is a protein that in humans is encoded by the TRAF4 gene.
Ceramide glucosyltransferase is an enzyme that in humans is encoded by the UGCG gene.
Neutral ceramidase is an enzyme that in humans is encoded by the ASAH2 gene.
Myosin-XVIIIa is a protein that in humans is encoded by the MYO18A gene.
BAG family molecular chaperone regulator 4 is a protein that in humans is encoded by the BAG4 gene.
Tumor necrosis factor receptor superfamily, member 19, also known as TNFRSF19 and TROY is a human gene.
52 kDa repressor of the inhibitor of the protein kinase is an enzyme that in humans is encoded by the PRKRIR gene.
Inositol-tetrakisphosphate 1-kinase is an enzyme that in humans is encoded by the ITPK1 gene.
Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene.
Sphingomyelin phosphodiesterase 2 is an enzyme that in humans is encoded by the SMPD2 gene.
39S ribosomal protein L41, mitochondrial is a protein that in humans is encoded by the MRPL41 gene.
Tumor necrosis factor receptor superfamily member 27 is a protein that in humans is encoded by the EDA2R gene.
 | This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it. |