SMU1

SMU1
Identifiers
Aliases	SMU1 , BWD, SMU-1, fSAP57, smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans), DNA replication regulator and spliceosomal factor, DNA replication regulator and spliceosomal factor, SMU1 DNA replication regulator and spliceosomal factor
External IDs	OMIM: 617811 MGI: 1915546 HomoloGene: 10079 GeneCards: SMU1
Gene location (Human)
Chr.	Chromosome 9 (human)
End	33,076,674 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	40,757,923 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; tendon; ; Achilles tendon; ; islet of Langerhans; ; monocyte; ; Brodmann area 23; ; corpus callosum; ; middle temporal gyrus; ; pons; ; ganglionic eminence;
	Top expressed in
	spermatocyte; ; secondary oocyte; ; spermatid; ; medial ganglionic eminence; ; primitive streak; ; maxillary prominence; ; abdominal wall; ; endocardial cushion; ; carotid body; ; dermis;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ;
Cellular component	cytoplasm ; nuclear speck ; nucleus ; U2-type precatalytic spliceosome ;
Biological process	regulation of alternative mRNA splicing, via spliceosome ; mRNA processing ; RNA splicing ; mRNA splicing, via spliceosome ;
	Sources:Amigo / QuickGO
Orthologs
	55234
	74255
	ENSG00000122692
	ENSMUSG00000028409
	Q2TAY7
	Q3UKJ7
	NM_018225
	NM_021535
	NP_060695 ; NP_060695.2
	NP_067510
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

WD40 repeat-containing protein SMU1 is a protein that in humans is encoded by the SMU1 gene.^[5]^[6]^[7]

Related Research Articles

WD repeat-containing protein 33 is a protein that in humans is encoded by the WDR33 gene.

WD repeat and SOCS box-containing protein 1 is a protein that in humans is encoded by the WSB1 gene.

Coronin-1C is a protein that in humans is encoded by the CORO1C gene.

WD repeat-containing protein 1 is a protein that in humans is encoded by the WDR1 gene.

Periodic tryptophan protein 1 homolog is a protein that in humans is encoded by the PWP1 gene.

Nuclear receptor-binding factor 2 is a protein that in humans is encoded by the NRBF2 gene.

39S ribosomal protein L11, mitochondrial is a protein that in humans is encoded by the MRPL11 gene.

Pleckstrin homology domain-containing family B member 2 is a protein that in humans is encoded by the PLEKHB2 gene.

WD repeat-containing protein 6 is a protein that in humans is encoded by the WDR6 gene.

Ankyrin repeat and SOCS box protein 3 is a protein that in humans is encoded by the ASB3 gene.

p21-activated protein kinase-interacting protein 1 is an enzyme that in humans is encoded by the PAK1IP1 gene.

GDP-fucose transporter 1 is a protein that in humans is encoded by the SLC35C1 gene.

Integrator complex subunit 9 is a protein that in Humans is encoded by the INTS9 gene.

EF-hand calcium-binding domain-containing protein 6 is a protein that in humans is encoded by the EFCAB6 gene.

Eukaryotic translation initiation factor 3, subunit M (eIF3m) also known as PCI domain containing 1 (herpesvirus entry mediator) (PCID1), is a protein that in humans is encoded by the EIF3M gene.

WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) is a protein that in humans is encoded by the WDR45 gene. Mutations in this gene cause a distinct form of Neurodegeneration with brain iron accumulation (NBIA) called Beta-propeller protein-associated neurodegeneration (BPAN).

Krueppel-related zinc finger protein 1 is a protein that in humans is encoded by the HKR1 gene.

Armadillo repeat-containing X-linked protein 1 is a protein that in humans is encoded by the ARMCX1 gene.

Tetratricopeptide repeat protein 4 is a protein that in humans is encoded by the TTC4 gene.

WD repeat-containing protein 26 is a protein that in humans is encoded by the WDR26 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000122692 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028409 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Spike CA, Shaw JE, Herman RK (Jul 2001). "Analysis of smu-1, a gene that regulates the alternative splicing of unc-52 pre-mRNA in Caenorhabditis elegans". Mol Cell Biol. 21 (15): 4985–95. doi:10.1128/MCB.21.15.4985-4995.2001. PMC 87225 . PMID 11438655.
↑ Di Benedetto AJ, Klick Stoddard J, Glavan BJ (Jun 2001). "Cloning and molecular characterization of a novel gene encoding a WD-repeat protein expressed in restricted areas of adult rat brain". Gene. 271 (1): 21–31. doi:10.1016/S0378-1119(01)00483-8. PMID 11410362.
↑ "Entrez Gene: SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081 . PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ficarro SB, Salomon AR, Brill LM, et al. (2005). "Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites". Rapid Commun. Mass Spectrom. 19 (1): 57–71. Bibcode:2005RCMS...19...57F. doi:10.1002/rcm.1746. PMID 15570572.
Higa LA, Wu M, Ye T, et al. (2006). "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation". Nat. Cell Biol. 8 (11): 1277–83. doi:10.1038/ncb1490. hdl:10397/34293. PMID 17041588. S2CID 22180568.

This protein-related article is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000122692 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028409 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11438655-5] Spike CA, Shaw JE, Herman RK (Jul 2001). "Analysis of smu-1, a gene that regulates the alternative splicing of unc-52 pre-mRNA in Caenorhabditis elegans". Mol Cell Biol. 21 (15): 4985–95. doi:10.1128/MCB.21.15.4985-4995.2001. PMC 87225 . PMID 11438655.

[pmid11410362-6] Di Benedetto AJ, Klick Stoddard J, Glavan BJ (Jun 2001). "Cloning and molecular characterization of a novel gene encoding a WD-repeat protein expressed in restricted areas of adult rat brain". Gene. 271 (1): 21–31. doi:10.1016/S0378-1119(01)00483-8. PMID 11410362.

[entrez-7] "Entrez Gene: SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

SMU1

Related Research Articles

References

Further reading