SORBS3

SORBS3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CT3, 2DLM, 2NWM, 2YUP
Identifiers
Aliases	SORBS3 , SCAM-1, SCAM1, SH3D4, sorbin and SH3 domain containing 3
External IDs	OMIM: 610795; MGI: 700013; HomoloGene: 4218; GeneCards: SORBS3; OMA:SORBS3 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8p21.3 Start 22,544,986 bp [1] End 22,575,788 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14 D2|14 36.27 cM Start 70,417,917 bp [2] End 70,449,438 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis right coronary artery popliteal artery tibial arteries tibial nerve gastric mucosa left coronary artery canal of the cervix ascending aorta Top expressed in external carotid artery muscle of thigh internal carotid artery genital tubercle retinal pigment epithelium vestibular membrane of cochlear duct ankle right lung right lung lobe choroid plexus of fourth ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function vinculin binding transcription factor binding structural constituent of cytoskeleton protein binding Cellular component cytoplasm cytosol cell junction cytoskeleton nucleus focal adhesion Biological process cell-substrate adhesion cell adhesion muscle contraction negative regulation of transcription by RNA polymerase II positive regulation of stress fiber assembly positive regulation of cytoskeleton organization positive regulation of MAPK cascade actin filament organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10174 20410 Ensembl ENSG00000120896 ENSMUSG00000022091 UniProt O60504 Q9R1Z8 RefSeq (mRNA) NM_001018003 NM_005775 NM_001271407 NM_001271408 NM_001271409 NM_011366 RefSeq (protein) NP_001018003 NP_005766 NP_001258336 NP_001258337 NP_001258338 NP_035496 Location (UCSC) Chr 8: 22.54 – 22.58 Mb Chr 14: 70.42 – 70.45 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Vinexin is a protein that in humans is encoded by the SORBS3 gene. ^{[5] [6] [7]}

Interactions

SORBS3 has been shown to interact with DLG5 ^[8] and MAPK1. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000120896 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022091 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kioka N, Sakata S, Kawauchi T, Amachi T, Akiyama SK, Okazaki K, Yaen C, Yamada KM, Aota S (Mar 1999). "Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization". J Cell Biol. 144 (1): 59–69. doi:10.1083/jcb.144.1.59. PMC   2148117 . PMID   9885244.
6. Kioka N (Jan 2003). "[A novel adaptor protein family regulating cytoskeletal organization and signal transduction--Vinexin, CAP/ponsin, ArgBP2]". Seikagaku. 74 (11): 1356–60. PMID   12510380.
7. "Entrez Gene: SORBS3 sorbin and SH3 domain containing 3".
8. Wakabayashi M, Ito Takuya, Mitsushima Masaru, Aizawa Sanae, Ueda Kazumitsu, Amachi Teruo, Kioka Noriyuki (Jun 2003). "Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact". J. Biol. Chem. 278 (24): 21709–14. doi: 10.1074/jbc.M211004200 . ISSN   0021-9258. PMID   12657639.
9. Mitsushima M, Suwa Akira, Amachi Teruo, Ueda Kazumitsu, Kioka Noriyuki (Aug 2004). "Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin". J. Biol. Chem. 279 (33): 34570–7. doi: 10.1074/jbc.M402304200 . ISSN   0021-9258. PMID   15184391.

Further reading

• Akamatsu M, Aota S, Suwa A, et al. (2000). "Vinexin forms a signaling complex with Sos and modulates epidermal growth factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activities". J. Biol. Chem. 274 (50): 35933–7. doi: 10.1074/jbc.274.50.35933 . PMID   10585480.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Wakabayashi M, Ito T, Mitsushima M, et al. (2003). "Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact". J. Biol. Chem. 278 (24): 21709–14. doi: 10.1074/jbc.M211004200 . PMID   12657639.
• Townson SM, Dobrzycka KM, Lee AV, et al. (2003). "SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor". J. Biol. Chem. 278 (22): 20059–68. doi: 10.1074/jbc.M212988200 . PMID   12660241.
• Mitsushima M, Suwa A, Amachi T, et al. (2004). "Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin". J. Biol. Chem. 279 (33): 34570–7. doi: 10.1074/jbc.M402304200 . PMID   15184391.
• Martens N, Wery M, Wang P, et al. (2004). "The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin". Exp. Cell Res. 298 (1): 239–48. doi:10.1016/j.yexcr.2004.04.002. PMID   15242778.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Bour G, Plassat JL, Bauer A, et al. (2005). "Vinexin beta interacts with the non-phosphorylated AF-1 domain of retinoid receptor gamma (RARgamma) and represses RARgamma-mediated transcription". J. Biol. Chem. 280 (17): 17027–37. doi: 10.1074/jbc.M501344200 . PMID   15734736.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Mitsushima M, Ueda K, Kioka N (2006). "Vinexin beta regulates the phosphorylation of epidermal growth factor receptor on the cell surface". Genes Cells. 11 (9): 971–82. doi: 10.1111/j.1365-2443.2006.00995.x . PMID   16923119. S2CID   24238810.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Mizutani K, Ito H, Iwamoto I, et al. (2007). "Essential roles of ERK-mediated phosphorylation of vinexin in cell spreading, migration and anchorage-independent growth". Oncogene. 26 (50): 7122–31. doi:10.1038/sj.onc.1210512. hdl: 20.500.12099/23093 . PMID   17486060. S2CID   9284621.

External links

• SORBS3 human gene location in the UCSC Genome Browser .
• SORBS3 human gene details in the UCSC Genome Browser .