SORBS3

Last updated
SORBS3
Protein SORBS3 PDB 2ct3.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SORBS3 , SCAM-1, SCAM1, SH3D4, sorbin and SH3 domain containing 3
External IDs OMIM: 610795 MGI: 700013 HomoloGene: 4218 GeneCards: SORBS3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001018003
NM_005775

NM_001271407
NM_001271408
NM_001271409
NM_011366

RefSeq (protein)

NP_001018003
NP_005766

NP_001258336
NP_001258337
NP_001258338
NP_035496

Location (UCSC) Chr 8: 22.54 – 22.58 Mb Chr 14: 70.18 – 70.21 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Vinexin is a protein that in humans is encoded by the SORBS3 gene. [5] [6] [7]

Contents


Interactions

SORBS3 has been shown to interact with DLG5 [8] and MAPK1. [9]

Related Research Articles

MAPK1

Mitogen-activated protein kinase 1, also known as MAPK1, p42MAPK, and ERK2, is an enzyme that in humans is encoded by the MAPK1 gene.

Fibroblast growth factor receptor 4

Fibroblast growth factor receptor 4 is a protein that in humans is encoded by the FGFR4 gene. FGFR4 has also been designated as CD334.

MAP2K3

Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene.

PTK2B

Protein tyrosine kinase 2 beta is an enzyme that in humans is encoded by the PTK2B gene.

CBLB (gene)

CBL-B is an E3 ubiquitin-protein ligase that in humans is encoded by the CBLB gene. CBLB is a member of the CBL gene family.

CAMK4

Calcium/calmodulin-dependent protein kinase type IV is an enzyme that in humans is encoded by the CAMK4 gene.

PRKCH

Protein kinase C eta type is an enzyme that in humans is encoded by the PRKCH gene.

ABL2

Tyrosine-protein kinase ABL2 also known as Abelson-related gene (Arg) is an enzyme that in humans is encoded by the ABL2 gene.

TNK2

Activated CDC42 kinase 1, also known as ACK1, is an enzyme that in humans is encoded by the TNK2 gene. TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor (IR). ACK1 also interacts with Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.

Megakaryocyte-associated tyrosine kinase

Megakaryocyte-associated tyrosine-protein kinase is an enzyme that in humans is encoded by the MATK gene.

CAMK1

Calcium/calmodulin-dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene.

DOK2

Docking protein 2 is a protein that in humans is encoded by the DOK2 gene.

DLG5

Disks large homolog 5 is a protein that in humans is encoded by the DLG5 gene.

MAPK8IP3

C-jun-amino-terminal kinase-interacting protein 3 is an enzyme that in humans is encoded by the MAPK8IP3 gene.

MAP3K12

Mitogen-activated protein kinase 12 is an enzyme that in humans is encoded by the MAP3K12 gene.

DLGAP1

Disks large-associated protein 1 (DAP-1), also known as guanylate kinase-associated protein (GKAP), is a protein that in humans is encoded by the DLGAP1 gene. DAP-1 is known to be highly enriched in synaptosomal preparations of the brain, and present in the post-synaptic density.

DLGAP2

Disks large-associated protein 2 is a protein that in humans is encoded by the DLGAP2 gene.

DUSP16

Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene.

DGKD

Diacylglycerol kinase delta is an enzyme that in humans is encoded by the DGKD gene.

MAPK12

Mitogen-activated protein kinase 12, also known as extracellular signal-regulated kinase 6 (ERK6) or stress-activated protein kinase 3 (SAPK3), is an enzyme that in humans is encoded by the MAPK12 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000120896 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022091 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kioka N; Sakata S; Kawauchi T; Amachi T; Akiyama SK; Okazaki K; Yaen C; Yamada KM; Aota S (Mar 1999). "Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization". J Cell Biol. 144 (1): 59–69. doi:10.1083/jcb.144.1.59. PMC   2148117 . PMID   9885244.
  6. Kioka N (Jan 2003). "[A novel adaptor protein family regulating cytoskeletal organization and signal transduction--Vinexin, CAP/ponsin, ArgBP2]". Seikagaku. 74 (11): 1356–60. PMID   12510380.
  7. "Entrez Gene: SORBS3 sorbin and SH3 domain containing 3".
  8. Wakabayashi, Makoto; Ito Takuya; Mitsushima Masaru; Aizawa Sanae; Ueda Kazumitsu; Amachi Teruo; Kioka Noriyuki (Jun 2003). "Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact". J. Biol. Chem. 278 (24): 21709–14. doi: 10.1074/jbc.M211004200 . ISSN   0021-9258. PMID   12657639.
  9. Mitsushima, Masaru; Suwa Akira; Amachi Teruo; Ueda Kazumitsu; Kioka Noriyuki (Aug 2004). "Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin". J. Biol. Chem. 279 (33): 34570–7. doi: 10.1074/jbc.M402304200 . ISSN   0021-9258. PMID   15184391.

Further reading