SP110

SP110
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1UFN
Identifiers
Aliases	SP110 , IFI41, IFI75, IPR1, VODI, SP110 nuclear body protein
External IDs	OMIM: 604457 MGI: 3783243 HomoloGene: 82192 GeneCards: SP110
Gene location (Human)
Chr.	Chromosome 2 (human)
End	230,225,729 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; lymph node; ; spleen; ; appendix; ; sural nerve; ; bone marrow cells; ; thymus; ; Achilles tendon; ; gallbladder;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	signal transducer activity ; metal ion binding ; DNA binding ; DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	nucleus ;
Biological process	regulation of transcription, DNA-templated ; transcription, DNA-templated ; viral process ; signal transduction ; regulation of transcription by RNA polymerase II ;
	Sources:Amigo / QuickGO
Orthologs
	3431
	101056250
	ENSG00000135899
	n/a
	Q9HB58
	n/a
NM_001185015 ; NM_004509 ; NM_004510 ; NM_080424 ; NM_001378442 ;
	NM_001378443 ; NM_001378444 ; NM_001378445 ; NM_001378446 ; NM_001378447 Contents References ; External links ; Further reading ;
	n/a
NP_001171944 ; NP_004500 ; NP_004501 ; NP_536349 ; NP_001365371 ;
	NP_001365372 ; NP_001365373 ; NP_001365374 ; NP_001365375 ; NP_001365376
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 03, 2023

SP110 nuclear body protein is a protein that in humans is encoded by the SP110 gene.^[4]^[5]^[6]

The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified.^[6]

Related Research Articles

Nuclear bodies are membraneless structures found in the cell nuclei of eukaryotic cells. Nuclear bodies include Cajal bodies, the nucleolus, and promyelocytic leukemia protein (PML) nuclear bodies. Nuclear bodies also include ND10s. ND stands for nuclear domain, and 10 refers to the number of dots seen.

Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional activator is a protein that in humans is encoded by the IFI16 gene.

Tripartite motif-containing 24 (TRIM24) also known as transcriptional intermediary factor 1α (TIF1α) is a protein that, in humans, is encoded by the TRIM24 gene.

Lipoma-preferred partner is a protein that in humans is encoded by the LPP gene.

Transcription elongation regulator 1, also known as TCERG1, is a protein which in humans is encoded by the TCERG1 gene.

K(lysine) acetyltransferase 6A (KAT6A), is an enzyme that, in humans, is encoded by the KAT6A gene. This gene is located on human chromosome 8, band 8p11.21.

Krueppel-like factor 10 is a protein that in humans is encoded by the KLF10 gene.

Adenylyl cyclase type 7 is an enzyme that in humans is encoded by the ADCY7 gene.

ETS domain-containing protein Elk-3 is a protein that in humans is encoded by the ELK3 gene.

Zinc finger protein 40 is a protein that in humans is encoded by the HIVEP1 gene.

Heat shock 70 kDa protein 6 is a protein that in humans is encoded by the HSPA6 gene.

Poly(rC)-binding protein 4 is a protein that in humans is encoded by the PCBP4 gene.

Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AL gene.

Histone H4 is a protein that in humans is encoded by the HIST1H4A gene.

Hepatic veno-occlusive disease (VOD) or veno-occlusive disease with immunodeficiency is a potentially life-threatening condition in which some of the small veins in the liver are obstructed. It is a complication of high-dose chemotherapy given before a bone marrow transplant and/or excessive exposure to hepatotoxic pyrrolizidine alkaloids. It is classically marked by weight gain due to fluid retention, increased liver size, and raised levels of bilirubin in the blood. The name sinusoidal obstruction syndrome (SOS) is preferred if hepatic veno-occlusive disease happens as a result of chemotherapy or bone marrow transplantation.

DNA-directed RNA polymerase III subunit RPC10 is an enzyme that in humans is encoded by the POLR3K gene.

Protein SOX-15 is a protein that in humans is encoded by the SOX15 gene.

Histone H2A.J is a protein that in humans is encoded by the H2AFJ gene.

Histone H3.1 is a protein that in humans is encoded by the HIST1H3H gene.

Mitogen-activated protein kinase 13, also known as stress-activated protein kinase 4 (SAPK4), is an enzyme that in humans is encoded by the MAPK13 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000135899 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kadereit S, Gewert DR, Galabru J, Hovanessian AG, Meurs EF (Dec 1993). "Molecular cloning of two new interferon-induced, highly related nuclear phosphoproteins". J Biol Chem. 268 (32): 24432–41. doi: 10.1016/S0021-9258(20)80544-4 . PMID 7693701.
↑ Welsh GI, Kadereit S, Coccia EM, Hovanessian AG, Meurs EF (Aug 1999). "Colocalization within the nucleolus of two highly related IFN-induced human nuclear phosphoproteins with nucleolin". Exp Cell Res. 250 (1): 62–74. doi:10.1006/excr.1999.4505. PMID 10388521.
1 2 "Entrez Gene: SP110 SP110 nuclear body protein".

External links

GeneReviews/NCBI/NIH/UW entry on Hepatic Veno-Occlusive Disease with Immunodeficiency

Bloch DB, Nakajima A, Gulick T, et al. (2000). "Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator". Mol. Cell. Biol. 20 (16): 6138–46. doi:10.1128/MCB.20.16.6138-6146.2000. PMC 86089 . PMID 10913195.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.
Watashi K, Hijikata M, Tagawa A, et al. (2003). "Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus". Mol. Cell. Biol. 23 (21): 7498–509. doi:10.1128/MCB.23.21.7498-7509.2003. PMC 207568 . PMID 14559998.
Nicewonger J, Suck G, Bloch D, Swaminathan S (2004). "Epstein-Barr virus (EBV) SM protein induces and recruits cellular Sp110b to stabilize mRNAs and enhance EBV lytic gene expression". J. Virol. 78 (17): 9412–22. doi:10.1128/JVI.78.17.9412-9422.2004. PMC 506926 . PMID 15308735.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Roscioli T, Cliffe ST, Bloch DB, et al. (2006). "Mutations in the gene encoding the PML nuclear body protein Sp110 are associated with immunodeficiency and hepatic veno-occlusive disease" (PDF). Nat. Genet. 38 (6): 620–2. doi:10.1038/ng1780. PMID 16648851. S2CID 1466106.
Tosh K, Campbell SJ, Fielding K, et al. (2006). "Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa". Proc. Natl. Acad. Sci. U.S.A. 103 (27): 10364–8. Bibcode:2006PNAS..10310364T. doi: 10.1073/pnas.0603340103 . PMC 1502463 . PMID 16803959.
Thye T, Browne EN, Chinbuah MA, et al. (2006). "No associations of human pulmonary tuberculosis with Sp110 variants". J. Med. Genet. 43 (7): e32. doi:10.1136/jmg.2005.037960. PMC 2564561 . PMID 16816019.
Warren EH, Vigneron NJ, Gavin MA, et al. (2006). "An antigen produced by splicing of noncontiguous peptides in the reverse order". Science. 313 (5792): 1444–7. Bibcode:2006Sci...313.1444W. doi:10.1126/science.1130660. PMID 16960008. S2CID 21808343.
Szeszko JS, Healy B, Stevens H, et al. (2007). "Resequencing and association analysis of the SP110 gene in adult pulmonary tuberculosis". Hum. Genet. 121 (2): 155–60. doi:10.1007/s00439-006-0293-z. PMID 17149599. S2CID 29689947.
Babb C, Keet EH, van Helden PD, Hoal EG (2007). "SP110 polymorphisms are not associated with pulmonary tuberculosis in a South African population". Hum. Genet. 121 (3–4): 521–2. doi:10.1007/s00439-007-0335-1. PMID 17287948. S2CID 13429697.
Cliffe ST, Wong M, Taylor PJ, et al. (2007). "The first prenatal diagnosis for veno-occlusive disease and immunodeficiency syndrome, an autosomal recessive condition associated with mutations in SP110". Prenat. Diagn. 27 (7): 674–6. doi:10.1002/pd.1759. PMID 17510920. S2CID 44723860.
de la Fuente J, Manzano-Roman R, Blouin EF, et al. (2007). "Sp110 transcription is induced and required by Anaplasma phagocytophilum for infection of human promyelocytic cells". BMC Infect. Dis. 7: 110. doi: 10.1186/1471-2334-7-110 . PMC 2039740 . PMID 17883869.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000135899 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7693701-4] Kadereit S, Gewert DR, Galabru J, Hovanessian AG, Meurs EF (Dec 1993). "Molecular cloning of two new interferon-induced, highly related nuclear phosphoproteins". J Biol Chem. 268 (32): 24432–41. doi: 10.1016/S0021-9258(20)80544-4 . PMID 7693701.

[pmid10388521-5] Welsh GI, Kadereit S, Coccia EM, Hovanessian AG, Meurs EF (Aug 1999). "Colocalization within the nucleolus of two highly related IFN-induced human nuclear phosphoproteins with nucleolin". Exp Cell Res. 250 (1): 62–74. doi:10.1006/excr.1999.4505. PMID 10388521.

[entrez-6] 1 2 "Entrez Gene: SP110 SP110 nuclear body protein".

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SP110

Contents

Related Research Articles

References

External links

Further reading