SPACA3

SPACA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4YF2
Identifiers
Aliases	SPACA3 , 1700025M08Rik, ALLP17, CT54, LYC3, LYZL3, SLLP1, LYZC, sperm acrosome associated 3
External IDs	OMIM: 612749; MGI: 1922872; HomoloGene: 18365; GeneCards: SPACA3; OMA:SPACA3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q11.2 Start 32,970,376 bp [1] End 32,997,877 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B5 Start 80,749,191 bp [2] End 80,758,640 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis sperm testicle body of pancreas gonad mucosa of transverse colon right coronary artery tibial nerve granulocyte Top expressed in spermatid seminiferous tubule spermatocyte lacrimal gland morula pancreas cochlea islet of Langerhans foregut stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding lysozyme activity Cellular component integral component of membrane extracellular region acrosomal vesicle secretory granule membrane cytoplasmic vesicle extracellular space acrosomal membrane acrosomal matrix Biological process monocyte activation cell wall macromolecule catabolic process fertilization positive regulation of phagocytosis response to virus positive regulation of macrophage activation sperm-egg recognition defense response to Gram-positive bacterium peptidoglycan catabolic process defense response to Gram-negative bacterium fusion of sperm to egg plasma membrane involved in single fertilization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 124912 75622 Ensembl ENSG00000141316 ENSMUSG00000053184 UniProt Q8IXA5 Q9D9X8 RefSeq (mRNA) NM_173847 NM_001317225 NM_001317226 NM_029367 NM_001359183 RefSeq (protein) NP_001304154 NP_001304155 NP_776246 NP_083643 NP_001346112 Location (UCSC) Chr 17: 32.97 – 33 Mb Chr 11: 80.75 – 80.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sperm acrosome membrane-associated protein 3 is a protein that in humans is encoded by the SPACA3 gene. It may be involved in adhesion to the egg before the egg is fertilized. ^{[5] [6]}

See also

• Acrosome

References

1. GRCh38: Ensembl release 89: ENSG00000141316 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053184 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mandal A, Klotz KL, Shetty J, Jayes FL, Wolkowicz MJ, Bolling LC, Coonrod SA, Black MB, Diekman AB, Haystead TA, Flickinger CJ, Herr JC (Apr 2003). "SLLP1, a unique, intra-acrosomal, non-bacteriolytic, c lysozyme-like protein of human spermatozoa". Biol Reprod. 68 (5): 1525–37. doi: 10.1095/biolreprod.102.010108 . PMID   12606493.
6. "Entrez Gene: SPACA3 sperm acrosome associated 3".

Further reading

• Niyonsaba F, Ogawa H (2006). "Protective roles of the skin against infection: implication of naturally occurring human antimicrobial agents beta-defensins, cathelicidin LL-37 and lysozyme". J. Dermatol. Sci. 40 (3): 157–68. doi:10.1016/j.jdermsci.2005.07.009. PMID   16150577.
• Cramer EM, Breton-Gorius J (1987). "Ultrastructural localization of lysozyme in human neutrophils by immunogold". J. Leukoc. Biol. 41 (3): 242–7. doi:10.1002/jlb.41.3.242. PMID   3470418. S2CID   32012371.
• Welsh IR, Spitznagel JK (1973). "Distribution of lysosomal enzymes, cationic proteins, and bactericidal substances in subcellular fractions of human polymorphonuclear leukocytes". Infect. Immun. 4 (2): 97–102. doi:10.1128/IAI.4.2.97-102.1971. PMC   416271 . PMID   5154881.
• Ibrahim HR, Matsuzaki T, Aoki T (2001). "Genetic evidence that antibacterial activity of lysozyme is independent of its catalytic function". FEBS Lett. 506 (1): 27–32. doi:10.1016/S0014-5793(01)02872-1. PMID   11591365. S2CID   21593262.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Wang Z, Zhang Y, Mandal A, et al. (2005). "The spermatozoa protein, SLLP1, is a novel cancer-testis antigen in hematologic malignancies". Clin. Cancer Res. 10 (19): 6544–50. doi: 10.1158/1078-0432.CCR-04-0911 . PMID   15475442.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Zhang K, Gao R, Zhang H, et al. (2006). "Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family". Biol. Reprod. 73 (5): 1064–71. doi: 10.1095/biolreprod.105.041889 . PMID   16014814. S2CID   21603980.