SPDYA

SPDYA
Identifiers
Aliases	SPDYA , RINGO3, RINGOA, SPDY1, SPY1, speedy/RINGO cell cycle regulator family member A
External IDs	OMIM: 614029; MGI: 1918141; HomoloGene: 16357; GeneCards: SPDYA; OMA:SPDYA - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p23.2 Start 28,782,517 bp [1] End 28,850,611 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 E1.3 Start 71,859,056 bp [2] End 71,896,528 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis sperm testicle Achilles tendon gonad left ovary granulocyte right ovary mucosa of transverse colon Top expressed in spermatocyte spermatid seminiferous tubule Stroma of ovary ooblast lumbar subsegment of spinal cord morula embryo tail of embryo ventricular zone More reference expression data BioGPS n/a
Gene ontology Molecular function protein kinase binding protein kinase activator activity Cellular component nucleus nucleoplasm Biological process multicellular organism development cell cycle positive regulation of cyclin-dependent protein serine/threonine kinase activity male meiotic nuclear division positive regulation of cell population proliferation cellular response to DNA damage stimulus activation of protein kinase activity positive regulation of protein kinase activity G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 245711 70891 Ensembl ENSG00000163806 ENSMUSG00000052525 UniProt Q5MJ70 Q5IBH7 RefSeq (mRNA) NM_182756 NM_001008779 NM_001142634 NM_001142631 NM_029254 RefSeq (protein) NP_001008779 NP_001136106 NP_877433 NP_001136103 NP_083530 Location (UCSC) Chr 2: 28.78 – 28.85 Mb Chr 17: 71.86 – 71.9 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Speedy protein A is a protein that in humans is encoded by the SPDYA gene. ^{[5] [6] [7] [8]}

Interactions

SPDYA has been shown to interact with CDKN1B. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000163806 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052525 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Porter LA, Dellinger RW, Tynan JA, Barnes EA, Kong M, Lenormand JL, Donoghue DJ (Apr 2002). "Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2". The Journal of Cell Biology. 157 (3): 357–66. doi:10.1083/jcb.200109045. PMC   2173287 . PMID   11980914.
6. Barnes EA, Porter LA, Lenormand JL, Dellinger RW, Donoghue DJ (Jul 2003). "Human Spy1 promotes survival of mammalian cells following DNA damage". Cancer Research. 63 (13): 3701–7. PMID   12839962.
7. Cheng A, Xiong W, Ferrell JE, Solomon MJ (Jan 2005). "Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins". Cell Cycle. 4 (1): 155–65. doi: 10.4161/cc.4.1.1347 . PMID   15611625.
8. "Entrez Gene: SPDYA speedy homolog A (Drosophila)".
9. Porter LA, Kong-Beltran M, Donoghue DJ (Sep 2003). "Spy1 interacts with p27Kip1 to allow G1/S progression". Molecular Biology of the Cell. 14 (9): 3664–74. doi:10.1091/mbc.E02-12-0820. PMC   196558 . PMID   12972555.

Further reading

• Porter LA, Kong-Beltran M, Donoghue DJ (Sep 2003). "Spy1 interacts with p27Kip1 to allow G1/S progression". Molecular Biology of the Cell. 14 (9): 3664–74. doi:10.1091/mbc.E02-12-0820. PMC   196558 . PMID   12972555.
• Gastwirt RF, Slavin DA, McAndrew CW, Donoghue DJ (Nov 2006). "Spy1 expression prevents normal cellular responses to DNA damage: inhibition of apoptosis and checkpoint activation". The Journal of Biological Chemistry. 281 (46): 35425–35. doi: 10.1074/jbc.M604720200 . PMID   16951407.
• McAndrew CW, Gastwirt RF, Meyer AN, Porter LA, Donoghue DJ (Aug 2007). "Spy1 enhances phosphorylation and degradation of the cell cycle inhibitor p27". Cell Cycle. 6 (15): 1937–45. doi: 10.4161/cc.6.15.4520 . PMID   17671428.