SPIN1

SPIN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2NS2, 4H75, 4MZF, 4MZG, 4MZH
Identifiers
Aliases	SPIN1 , SPIN, TDRD24, spindlin 1
External IDs	OMIM: 609936 MGI: 109242 HomoloGene: 55983 GeneCards: SPIN1
Gene location (Human)
Chr.	Chromosome 9 (human)
End	88,478,694 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	51,306,582 bp
RNA expression pattern
	Top expressed in
	postcentral gyrus; ; caput epididymis; ; corpus epididymis; ; superior vestibular nucleus; ; middle temporal gyrus; ; entorhinal cortex; ; Brodmann area 23; ; seminal vesicula; ; renal medulla; ; superior frontal gyrus;
	Top expressed in
	secondary oocyte; ; fossa; ; condyle; ; motor neuron; ; Paneth cell; ; substantia nigra; ; facial motor nucleus; ; medial ganglionic eminence; ; vas deferens; ; barrel cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methylated histone binding ; protein binding ;
Cellular component	nucleus ; spindle ; nucleolus ; nucleoplasm ; cytosol ; nuclear membrane ;
Biological process	multicellular organism development ; Wnt signaling pathway ; cell cycle ; meiosis ; rRNA transcription ; gamete generation ; positive regulation of Wnt signaling pathway ; positive regulation of transcription, DNA-templated ; chromatin organization ;
	Sources:Amigo / QuickGO
Orthologs
	10927
	20729
	ENSG00000106723
	ENSMUSG00000021395
	Q9Y657
	Q61142
	NM_006717
	NM_001283028 ; NM_001283029 ; NM_001283030 ; NM_011462 ; NM_146043
	NP_006708
	NP_001269957 ; NP_001269958 ; NP_001269959 ; NP_035592 ; NP_666155
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 19, 2023

Spindlin-1 is a protein that in humans is encoded by the SPIN1 gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000106723 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021395 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gao Y, Yue W, Zhang P, Li L, Xie X, Yuan H, Chen L, Liu D, Yan F, Pei X (Aug 2005). "Spindlin1, a novel nuclear protein with a role in the transformation of NIH3T3 cells". Biochem Biophys Res Commun. 335 (2): 343–50. doi:10.1016/j.bbrc.2005.07.087. PMID 16098913. S2CID 44944387.
↑ "Entrez Gene: SPIN1 spindlin 1".

Oh B, Hwang SY, Solter D, Knowles BB (1997). "Spindlin, a major maternal transcript expressed in the mouse during the transition from oocyte to embryo". Development. 124 (2): 493–503. doi:10.1242/dev.124.2.493. PMID 9053325.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732 . PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081 . PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID 16381901.
Jiang F, Zhao Q, Qin L, et al. (2006). "Expression, purification, crystallization and preliminary X-ray analysis of human spindlin1, an ovarian cancer-related protein". Protein Pept. Lett. 13 (2): 203–5. doi:10.2174/092986606775101661. PMID 16472086.
Zhao Q, Qin L, Jiang F, et al. (2007). "Structure of human spindlin1. Tandem tudor-like domains for cell cycle regulation". J. Biol. Chem. 282 (1): 647–56. doi:10.1074/jbc.M604029200. PMID 17082182.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000106723 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021395 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16098913-5] Gao Y, Yue W, Zhang P, Li L, Xie X, Yuan H, Chen L, Liu D, Yan F, Pei X (Aug 2005). "Spindlin1, a novel nuclear protein with a role in the transformation of NIH3T3 cells". Biochem Biophys Res Commun. 335 (2): 343–50. doi:10.1016/j.bbrc.2005.07.087. PMID 16098913. S2CID 44944387.

[entrez-6] "Entrez Gene: SPIN1 spindlin 1".

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SPIN1

Related Research Articles

References

Further reading