SPOCK1

SPOCK1
Identifiers
Aliases	SPOCK1 , SPOCK, TESTICAN, TIC1, sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1, SPARC/osteonectin, cwcv and kazal like domains proteoglycan 1, SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1
External IDs	OMIM: 602264; MGI: 105371; HomoloGene: 80193; GeneCards: SPOCK1; OMA:SPOCK1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q31.2 Start 136,975,298 bp [1] End 137,598,379 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 B1 Start 57,569,008 bp [2] End 58,056,146 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium lateral nuclear group of thalamus decidua postcentral gyrus Brodmann area 46 orbitofrontal cortex cerebellar cortex cerebellar hemisphere superior frontal gyrus right hemisphere of cerebellum Top expressed in medial dorsal nucleus medial geniculate nucleus superior frontal gyrus primary visual cortex olfactory system olfactory epithelium cerebellar cortex Gray matter of spinal cord anterior horn of spinal cord dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding cysteine-type endopeptidase inhibitor activity metalloendopeptidase inhibitor activity serine-type endopeptidase inhibitor activity collagen binding extracellular matrix binding Cellular component cytoplasm postsynaptic density neuromuscular junction node of Ranvier extracellular region sarcoplasm extracellular space Biological process negative regulation of cell-substrate adhesion neurogenesis negative regulation of neuron projection development neuron migration nervous system development cell adhesion regulation of cell growth central nervous system neuron differentiation signal transduction negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6695 20745 Ensembl ENSG00000152377 ENSMUSG00000056222 UniProt Q08629 Q62288 RefSeq (mRNA) NM_004598 NM_001166463 NM_001166464 NM_001166465 NM_001166466 NM_009262 RefSeq (protein) NP_004589 n/a Location (UCSC) Chr 5: 136.98 – 137.6 Mb Chr 13: 57.57 – 58.06 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Testican-1 is a protein that in humans is encoded by the SPOCK1 gene. ^{[5] [6]}

This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is under research, though it is from the same family of glycoproteins as SPARC. It is thought its similarity to thyropin-type cysteine protease inhibitors suggests its function may be related to protease inhibition. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000152377 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000056222 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Charbonnier F, Perin JP, Mattei MG, Camuzat A, Bonnet F, Gressin L, Alliel PM (Jun 1998). "Genomic organization of the human SPOCK gene and its chromosomal localization to 5q31". Genomics. 48 (3): 377–80. doi:10.1006/geno.1997.5199. PMID   9545645.
6. "Entrez Gene: SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1".

Further reading

• Périn JP, Alliel PM, Jollès P, Bonnet F (1994). "Proteoglycans in male reproductive tract". Proteoglycans. Vol. 70. pp. 191–7. doi:10.1007/978-3-0348-7545-5_11 (inactive 1 July 2025). ISBN   978-3-0348-7547-9. PMID   7507743.
• Charbonnier F, Périn JP, Roussel G, et al. (1997). "[Cloning of testican/SPOCK in man and mouse. Neuromuscular expression perspectives in pathology]". C. R. Séances Soc. Biol. Fil. 191 (1): 127–33. PMID   9181134.
• Alliel PM, Perin JP, Jollès P, Bonnet FJ (1993). "Testican, a multidomain testicular proteoglycan resembling modulators of cell social behaviour". Eur. J. Biochem. 214 (1): 347–50. doi:10.1111/j.1432-1033.1993.tb17930.x. PMID   8389704.
• Bonnet F, Périn JP, Charbonnier F, et al. (1996). "Structure and cellular distribution of mouse brain testican. Association with the postsynaptic area of hippocampus pyramidal cells". J. Biol. Chem. 271 (8): 4373–80. doi: 10.1074/jbc.271.8.4373 . PMID   8626787.
• Marr HS, Basalamah MA, Edgell CJ (1998). "Endothelial cell expression of testican mRNA". Endothelium. 5 (3): 209–19. doi:10.3109/10623329709053399. PMID   9272383.
• Kohfeldt E, Maurer P, Vannahme C, Timpl R (1997). "Properties of the extracellular calcium binding module of the proteoglycan testican". FEBS Lett. 414 (3): 557–61. Bibcode:1997FEBSL.414..557K. doi: 10.1016/S0014-5793(97)01070-3 . PMID   9323035. S2CID   25552375.
• Marr HS, Basalamah MA, Bouldin TW, et al. (2001). "Distribution of testican expression in human brain". Cell Tissue Res. 302 (2): 139–44. doi:10.1007/s004410000277. PMID   11131125. S2CID   9937680.
• BaSalamah MA, Marr HS, Duncan AW, Edgell CJ (2001). "Testican in human blood". Biochem. Biophys. Res. Commun. 283 (5): 1083–90. doi:10.1006/bbrc.2001.4900. PMID   11355883.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Nakada M, Miyamori H, Yamashita J, Sato H (2003). "Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins". Cancer Res. 63 (12): 3364–9. PMID   12810672.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5". Nature. 431 (7006): 268–74. Bibcode:2004Natur.431..268S. doi: 10.1038/nature02919 . PMID   15372022.
• Prenzel KL, Warnecke-Eberz U, Xi H, et al. (2006). "Significant overexpression of SPARC/osteonectin mRNA in pancreatic cancer compared to cancer of the papilla of Vater". Oncol. Rep. 15 (5): 1397–401. doi: 10.3892/or.15.5.1397 . PMID   16596217.