SPOCK1

SPOCK1
Identifiers
Aliases	SPOCK1 , SPOCK, TESTICAN, TIC1, sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1, SPARC/osteonectin, cwcv and kazal like domains proteoglycan 1, SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1
External IDs	OMIM: 602264 MGI: 105371 HomoloGene: 80193 GeneCards: SPOCK1
Gene location (Human)
Chr.	Chromosome 5 (human)
End	137,598,379 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	58,056,146 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; postcentral gyrus; ; Brodmann area 46; ; orbitofrontal cortex; ; cerebellar cortex; ; cerebellar hemisphere; ; superior frontal gyrus; ; entorhinal cortex; ; inferior olivary nucleus; ; pons;
	Top expressed in
	medial dorsal nucleus; ; medial geniculate nucleus; ; superior frontal gyrus; ; olfactory epithelium; ; cerebellar cortex; ; anterior horn of spinal cord; ; lateral geniculate nucleus; ; primary motor cortex; ; prefrontal cortex; ; dorsomedial hypothalamic nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding ; cysteine-type endopeptidase inhibitor activity ; metalloendopeptidase inhibitor activity ; serine-type endopeptidase inhibitor activity ; collagen binding ; extracellular matrix binding ;
Cellular component	cytoplasm ; postsynaptic density ; neuromuscular junction ; node of Ranvier ; extracellular region ; sarcoplasm ; extracellular space ;
Biological process	negative regulation of cell-substrate adhesion ; neurogenesis ; negative regulation of neuron projection development ; neuron migration ; nervous system development ; cell adhesion ; regulation of cell growth ; central nervous system neuron differentiation ; signal transduction ; negative regulation of endopeptidase activity ;
	Sources:Amigo / QuickGO
Orthologs
	6695
	20745
	ENSG00000152377
	ENSMUSG00000056222
	Q08629
	Q62288
	NM_004598
	NM_001166463 ; NM_001166464 ; NM_001166465 ; NM_001166466 ; NM_009262
	NP_004589
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated February 08, 2024

Testican-1 is a protein that in humans is encoded by the SPOCK1 gene.^[5]^[6]

This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is under research, though it is from the same family of glycoproteins as SPARC. It is thought its similarity to thyropin-type cysteine protease inhibitors suggests its function may be related to protease inhibition.^[6]

Related Research Articles

<span class="mw-page-title-main">Agrin</span> Mammalian protein found in Homo sapiens

Agrin is a large proteoglycan whose best-characterised role is in the development of the neuromuscular junction during embryogenesis. Agrin is named based on its involvement in the aggregation of acetylcholine receptors during synaptogenesis. In humans, this protein is encoded by the AGRN gene.

Decorin is a protein that in humans is encoded by the DCN gene.

Osteonectin (ON) also known as secreted protein acidic and rich in cysteine (SPARC) or basement-membrane protein 40 (BM-40) is a protein that in humans is encoded by the SPARC gene.

Phosphatidylethanolamine-binding protein 1 is a protein that in humans is encoded by the PEBP1 gene.

Collagen alpha-2(VI) chain is a protein that in humans is encoded by the COL6A2 gene.

<span class="mw-page-title-main">ADAMTS1</span> Protein-coding gene in the species Homo sapiens

A disintegrin and metalloproteinase with thrombospondin motifs 1 is an enzyme that in humans is encoded by the ADAMTS1 gene.

Serglycin, also known as hematopoietic proteoglycan core protein or secretory granule proteoglycan core protein, is a protein that in humans is encoded by the SRGN gene. It is primarily expressed in hematopoietic cells and endothelial cells, and is the only known intracellular proteoglycan.

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 is an enzyme that in humans is encoded by the B3GAT3 gene.

SPARC-like protein 1, also known as hevin, is a secreted protein with high structural similarity to SPARC. It interacts with the extracellular matrix to create intermediate states of cell adhesion. Due to its dynamic extracellular roles, being implicated in cancer metastasis and inflammation, it is considered a matricellular protein. In humans hevin is encoded by the SPARCL1 gene.

NEDD8-conjugating enzyme Ubc12 is a protein that in humans is encoded by the UBE2M gene.

A disintegrin and metalloproteinase with thrombospondin motifs 9 is an enzyme that in humans is encoded by the ADAMTS9 gene.

Zinc finger protein 267 is a protein that in humans is encoded by the ZNF267 gene.

Protein HEXIM2 is a protein that in humans is encoded by the HEXIM2 gene.

Glypican-5 is a protein that in humans is encoded by the GPC5 gene.

Fetuin-B is a protein that in humans is encoded by the FETUB gene.

Osteomodulin is a protein that in humans is encoded by the OMD gene.

Testican-2 is a protein that in humans is encoded by the SPOCK2 gene.

Chondroitin sulfate proteoglycan 5 is a protein that in humans is encoded by the CSPG5 gene.

Neuronal pentraxin receptor is a protein that in humans is encoded by the NPTXR gene.

Synaptonemal complex protein 1 is a protein involved in the synaptonemal complex during meiosis, that in humans is encoded by the SYCP1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000152377 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056222 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Charbonnier F, Perin JP, Mattei MG, Camuzat A, Bonnet F, Gressin L, Alliel PM (Jun 1998). "Genomic organization of the human SPOCK gene and its chromosomal localization to 5q31". Genomics. 48 (3): 377–80. doi:10.1006/geno.1997.5199. PMID 9545645.
1 2 "Entrez Gene: SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1".

Périn JP, Alliel PM, Jollès P, Bonnet F (1994). "Proteoglycans in male reproductive tract". Exs. 70: 191–7. doi:10.1007/978-3-0348-7545-5_11 (inactive 2024-02-07). ISBN 978-3-0348-7547-9. PMID 7507743.{{cite journal}}: CS1 maint: DOI inactive as of February 2024 (link)
Charbonnier F, Périn JP, Roussel G, et al. (1997). "[Cloning of testican/SPOCK in man and mouse. Neuromuscular expression perspectives in pathology]". C. R. Séances Soc. Biol. Fil. 191 (1): 127–33. PMID 9181134.
Alliel PM, Perin JP, Jollès P, Bonnet FJ (1993). "Testican, a multidomain testicular proteoglycan resembling modulators of cell social behaviour". Eur. J. Biochem. 214 (1): 347–50. doi:10.1111/j.1432-1033.1993.tb17930.x. PMID 8389704.
Bonnet F, Périn JP, Charbonnier F, et al. (1996). "Structure and cellular distribution of mouse brain testican. Association with the postsynaptic area of hippocampus pyramidal cells". J. Biol. Chem. 271 (8): 4373–80. doi: 10.1074/jbc.271.8.4373 . PMID 8626787.
Marr HS, Basalamah MA, Edgell CJ (1998). "Endothelial cell expression of testican mRNA". Endothelium. 5 (3): 209–19. doi:10.3109/10623329709053399. PMID 9272383.
Kohfeldt E, Maurer P, Vannahme C, Timpl R (1997). "Properties of the extracellular calcium binding module of the proteoglycan testican". FEBS Lett. 414 (3): 557–61. doi: 10.1016/S0014-5793(97)01070-3 . PMID 9323035. S2CID 25552375.
Marr HS, Basalamah MA, Bouldin TW, et al. (2001). "Distribution of testican expression in human brain". Cell Tissue Res. 302 (2): 139–44. doi:10.1007/s004410000277. PMID 11131125. S2CID 9937680.
BaSalamah MA, Marr HS, Duncan AW, Edgell CJ (2001). "Testican in human blood". Biochem. Biophys. Res. Commun. 283 (5): 1083–90. doi:10.1006/bbrc.2001.4900. PMID 11355883.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Nakada M, Miyamori H, Yamashita J, Sato H (2003). "Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins". Cancer Res. 63 (12): 3364–9. PMID 12810672.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5". Nature. 431 (7006): 268–74. Bibcode:2004Natur.431..268S. doi: 10.1038/nature02919 . PMID 15372022.
Prenzel KL, Warnecke-Eberz U, Xi H, et al. (2006). "Significant overexpression of SPARC/osteonectin mRNA in pancreatic cancer compared to cancer of the papilla of Vater". Oncol. Rep. 15 (5): 1397–401. doi: 10.3892/or.15.5.1397 . PMID 16596217.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000152377 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056222 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9545645-5] Charbonnier F, Perin JP, Mattei MG, Camuzat A, Bonnet F, Gressin L, Alliel PM (Jun 1998). "Genomic organization of the human SPOCK gene and its chromosomal localization to 5q31". Genomics. 48 (3): 377–80. doi:10.1006/geno.1997.5199. PMID 9545645.

[entrez-6] 1 2 "Entrez Gene: SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1".

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SPOCK1

Related Research Articles

References

Further reading