SPOCK2

Last updated
SPOCK2
Identifiers
Aliases SPOCK2 , testican-2, sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2, SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2, SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
External IDs OMIM: 607988 MGI: 1891351 HomoloGene: 8854 GeneCards: SPOCK2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001134434
NM_001244950
NM_014767

NM_052994

RefSeq (protein)

NP_001127906
NP_001231879
NP_055582

NP_443720

Location (UCSC) Chr 10: 72.06 – 72.09 Mb Chr 10: 59.94 – 59.97 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Testican-2 is a protein that in humans is encoded by the SPOCK2 gene. [5] [6]

Contents

Function

Proteoglycans, which consist of a core protein and covalently linked glycosaminoglycans, are components of the extracellular matrix. SPOCK2 encodes a member of a novel Ca(2+)-binding proteoglycan family.[supplied by OMIM] [6]

Related Research Articles

<span class="mw-page-title-main">Osteoglycin</span> Protein-coding gene in the species Homo sapiens

Osteoglycin, encoded by the OGN gene, is a human protein.

<span class="mw-page-title-main">KMT2C</span> Protein-coding gene in the species Homo sapiens

Lysine N-methyltransferase 2C (KMT2C) also known as myeloid/lymphoid or mixed-lineage leukemia protein 3 (MLL3) is an enzyme that in humans is encoded by the KMT2C gene.

<span class="mw-page-title-main">CALCOCO1</span> Protein-coding gene in humans

Calcium-binding and coiled-coil domain-containing protein 1 is a protein that in humans is encoded by the CALCOCO1 gene.

<span class="mw-page-title-main">DNAJB9</span> Protein-coding gene in the species Homo sapiens

DnaJ homolog subfamily B member 9 is a protein that in humans is encoded by the DNAJB9 gene.

<span class="mw-page-title-main">Brevican</span> Protein-coding gene in the species Homo sapiens

Brevican core protein is a protein that in humans is encoded by the BCAN gene. Brevican is a member of the lectican protein family.

<span class="mw-page-title-main">Spondin 1</span> Protein-coding gene in the species Homo sapiens

Spondin-1 is a protein that in humans is encoded by the SPON1 gene. It is secreted by cells of the floor plate and may be involved in axon guidance The protein contains 807 amino acids and is structurally composed of six thrombospondin domains, one reelin domain, and one spondin domain.

<span class="mw-page-title-main">SNF1LK2</span> Protein-coding gene in the species Homo sapiens

Serine/threonine-protein kinase SIK2 is an enzyme that in humans is encoded by the SIK2 gene.

<span class="mw-page-title-main">ERG28</span> Protein-coding gene in the species Homo sapiens

Ergosterol biosynthetic protein 28 is a protein that in humans is encoded by the ERG28 gene.

<span class="mw-page-title-main">SIPA1L1</span> Protein-coding gene in the species Homo sapiens

Signal-induced proliferation-associated 1-like protein 1 is a protein that in humans is encoded by the SIPA1L1 gene.

<span class="mw-page-title-main">PDZD11</span> Protein-coding gene in the species Homo sapiens

PDZ domain-containing protein 11 is a protein that in humans is encoded by the PDZD11 gene.

<span class="mw-page-title-main">TIMMDC1</span> Protein-coding gene in the species Homo sapiens

TIMMDC1 is a protein that in humans is encoded by the TIMMDC1 gene. It is a chaperone protein involved in constructing the membrane arm of mitochondrial Complex I. A frameshift mutation in an intron of this gene has been shown to cause failure to thrive, retardation of psychomotor development, infantile-onset hypotonia, and severe neurologic dysfunction. High expression of this gene has been associated with migration of lung cancer cells while depletion of the protein has been shown to affect regulation of apoptosis, the cell cycle, and cell migration.

<span class="mw-page-title-main">ZCCHC2</span> Protein-coding gene in the species Homo sapiens

Zinc finger CCHC domain-containing protein 2 is a protein that in humans is encoded by the ZCCHC2 gene.

<span class="mw-page-title-main">C6orf89</span> Protein-coding gene in the species Homo sapiens

Uncharacterized protein C6orf89 is a protein that in humans is encoded by the C6orf89 gene.

<span class="mw-page-title-main">SYT13</span> Protein-coding gene in the species Homo sapiens

Synaptotagmin-13 is a protein that in humans is encoded by the SYT13 gene.

<span class="mw-page-title-main">LMBR1L</span> Protein-coding gene in humans

Protein LMBR1L is a protein that in humans is encoded by the LMBR1L gene.

<span class="mw-page-title-main">ZNF471</span> Protein-coding gene in the species Homo sapiens

Zinc finger protein 471 is a protein that in humans is encoded by the ZNF471 gene.

<span class="mw-page-title-main">RNF10</span> Protein-coding gene in the species Homo sapiens

RING finger protein 10 is a protein that in humans is encoded by the RNF10 gene.

<span class="mw-page-title-main">CSPG5</span> Protein-coding gene in the species Homo sapiens

Chondroitin sulfate proteoglycan 5 is a protein that in humans is encoded by the CSPG5 gene.

<span class="mw-page-title-main">FLRT2</span> Protein-coding gene in the species Homo sapiens

Fibronectin leucine-rich repeat transmembrane protein FLRT2 is a protein that in humans is encoded by the FLRT2 gene.

<span class="mw-page-title-main">TSHZ3</span> Protein-coding gene in the species Homo sapiens

Teashirt homolog 3 is a protein that in humans is encoded by the TSHZ3 gene. In mice, it is a necessary part of the neural circuitry that controls breathing. The gene is also a homolog of the Drosophila melanogaster teashirt gene, which encodes a zinc finger transcription factor important for development of the trunk.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000107742 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000058297 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Vannahme C, Schübel S, Herud M, Gösling S, Hülsmann H, Paulsson M, Hartmann U, Maurer P (July 1999). "Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain". Journal of Neurochemistry. 73 (1): 12–20. doi:10.1046/j.1471-4159.1999.0730012.x. PMID   10386950. S2CID   21955542.
  6. 1 2 "Entrez Gene: SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2".

Further reading