SPOCK2

SPOCK2
Identifiers
Aliases	SPOCK2 , testican-2, sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2, SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2, SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
External IDs	OMIM: 607988 MGI: 1891351 HomoloGene: 8854 GeneCards: SPOCK2
Gene location (Human)
Chr.	Chromosome 10 (human)
End	72,089,032 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	59,971,020 bp
RNA expression pattern
	Top expressed in
	Brodmann area 10; ; spinal ganglia; ; cerebellar vermis; ; middle frontal gyrus; ; superior vestibular nucleus; ; pons; ; inferior olivary nucleus; ; external globus pallidus; ; nucleus accumbens; ; ventral tegmental area;
	Top expressed in
	habenula; ; entorhinal cortex; ; dorsomedial hypothalamic nucleus; ; superior colliculus; ; medial dorsal nucleus; ; subiculum; ; dorsal tegmental nucleus; ; medulla oblongata; ; lateral geniculate nucleus; ; inferior colliculus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding ; glycosaminoglycan binding ; extracellular matrix binding ; metalloendopeptidase inhibitor activity ; collagen binding ;
Cellular component	extracellular region ; extracellular matrix ; extracellular space ;
Biological process	regulation of cell differentiation ; synapse assembly ; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan ; extracellular matrix organization ; signal transduction ; positive regulation of cell-substrate adhesion ; negative regulation of endopeptidase activity ; positive regulation of cell motility ; cellular response to leukemia inhibitory factor ;
	Sources:Amigo / QuickGO
Orthologs
	9806
	94214
	ENSG00000107742
	ENSMUSG00000058297
	Q92563
	Q9ER58
	NM_001134434 ; NM_001244950 ; NM_014767
	NM_052994
	NP_001127906 ; NP_001231879 ; NP_055582
	NP_443720
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated February 26, 2024

Testican-2 is a protein that in humans is encoded by the SPOCK2 gene.^[5]^[6]

Function

Proteoglycans, which consist of a core protein and covalently linked glycosaminoglycans, are components of the extracellular matrix. SPOCK2 encodes a member of a novel Ca(2+)-binding proteoglycan family.[supplied by OMIM]^[6]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000107742 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000058297 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Vannahme C, Schübel S, Herud M, Gösling S, Hülsmann H, Paulsson M, Hartmann U, Maurer P (July 1999). "Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain". Journal of Neurochemistry. 73 (1): 12–20. doi:10.1046/j.1471-4159.1999.0730012.x. PMID 10386950. S2CID 21955542.
1 2 "Entrez Gene: SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2".

Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. CiteSeerX 10.1.1.319.3770 . doi: 10.1093/dnares/3.5.321 . PMID 9039502.
Nakayama M, Kikuno R, Ohara O (November 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542 . PMID 12421765.
Nakada M, Miyamori H, Yamashita J, Sato H (June 2003). "Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins". Cancer Research. 63 (12): 3364–9. PMID 12810672.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551 . PMID 15340161.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000107742 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000058297 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10386950-5] Vannahme C, Schübel S, Herud M, Gösling S, Hülsmann H, Paulsson M, Hartmann U, Maurer P (July 1999). "Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain". Journal of Neurochemistry. 73 (1): 12–20. doi:10.1046/j.1471-4159.1999.0730012.x. PMID 10386950. S2CID 21955542.

[entrez-6] 1 2 "Entrez Gene: SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2".

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SPOCK2

Contents

Function

Related Research Articles

References

Further reading