SPRED2

SPRED2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JP2
Identifiers
Aliases	SPRED2 , Spred-2, sprouty related EVH1 domain containing 2, NS14
External IDs	OMIM: 609292 MGI: 2150019 HomoloGene: 24918 GeneCards: SPRED2
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p14 Start 65,310,851 bp [1] End 65,432,637 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 A3.1 Start 19,874,375 bp [2] End 19,974,026 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve postcentral gyrus prefrontal cortex superior frontal gyrus Brodmann area 46 dorsolateral prefrontal cortex ascending aorta cingulate gyrus ganglionic eminence right lung Top expressed in primitive streak prefrontal cortex cingulate gyrus hair follicle primary motor cortex hippocampus proper cerebellar vermis nucleus accumbens subiculum parotid gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein kinase binding protein serine/threonine kinase inhibitor activity stem cell factor receptor binding Cellular component cytoplasm plasma membrane transport vesicle membrane membrane cytoplasmic vesicle cytosol Biological process multicellular organism development negative regulation of peptidyl-threonine phosphorylation regulation of signal transduction fibroblast growth factor receptor signaling pathway regulation of protein deacetylation positive regulation of DNA damage response, signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 200734 114716 Ensembl ENSG00000198369 ENSMUSG00000045671 UniProt Q7Z698 Q924S7 RefSeq (mRNA) NM_001128210 NM_181784 NM_033523 RefSeq (protein) NP_001121682 NP_861449 NP_277058 Location (UCSC) Chr 2: 65.31 – 65.43 Mb Chr 11: 19.87 – 19.97 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sprouty-related, EVH1 domain-containing protein 2 is a protein that in humans is encoded by the SPRED2 gene. ^[5]

Function

SPRED2 is a member of the Sprouty (see SPRY1)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1 ^[5] ).

References

1. GRCh38: Ensembl release 89: ENSG00000198369 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000045671 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SPRED2 sprouty-related, EVH1 domain containing 2".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Wakioka T, Sasaki A, Kato R, et al. (2001). "Spred is a Sprouty-related suppressor of Ras signalling". Nature. 412 (6847): 647–51. Bibcode:2001Natur.412..647W. doi:10.1038/35088082. PMID   11493923. S2CID   4345140.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Kato R, Nonami A, Taketomi T, et al. (2003). "Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation". Biochem. Biophys. Res. Commun. 302 (4): 767–72. doi:10.1016/S0006-291X(03)00259-6. PMID   12646235.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Nobuhisa I, Kato R, Inoue H, et al. (2004). "Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activation". J. Exp. Med. 199 (5): 737–42. doi:10.1084/jem.20030830. PMC   2213301 . PMID   14981116.
• Miyoshi K, Wakioka T, Nishinakamura H, et al. (2004). "The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization". Oncogene. 23 (33): 5567–76. doi: 10.1038/sj.onc.1207759 . PMID   15184877.
• Zimmermann J, Jarchau T, Walter U, et al. (2005). "1H, 13C and 15N resonance assignment of the human Spred2 EVH1 domain". J. Biomol. NMR. 29 (3): 435–6. doi:10.1023/B:JNMR.0000032526.17586.8c. PMID   15213456. S2CID   37933714.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Engelhardt CM, Bundschu K, Messerschmitt M, et al. (2005). "Expression and subcellular localization of Spred proteins in mouse and human tissues". Histochem. Cell Biol. 122 (6): 527–38. doi:10.1007/s00418-004-0725-6. PMID   15580519. S2CID   24496085.
• King JA, Straffon AF, D'Abaco GM, et al. (2005). "Distinct requirements for the Sprouty domain for functional activity of Spred proteins". Biochem. J. 388 (Pt 2): 445–54. doi:10.1042/BJ20041284. PMC   1138951 . PMID   15683364.
• Bundschu K, Knobeloch KP, Ullrich M, et al. (2005). "Gene disruption of Spred-2 causes dwarfism". J. Biol. Chem. 280 (31): 28572–80. doi: 10.1074/jbc.M503640200 . PMID   15946934.
• Yoshida T, Hisamoto T, Akiba J, et al. (2006). "Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors". Oncogene. 25 (45): 6056–66. doi: 10.1038/sj.onc.1209635 . PMID   16652141.
• Lock P, I ST, Straffon AF, et al. (2007). "Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination". Biochem. Biophys. Res. Commun. 351 (4): 1018–23. doi:10.1016/j.bbrc.2006.10.150. PMID   17094949.

External links

• GeneReviews/NIH/NCBI/UW entry on Legius syndrome SPRED1 Sprouty-related, EVH1 domain-containing protein 1