SPRED3

SPRED3
Identifiers
Aliases	SPRED3 , Eve-3, spred-3, sprouty related EVH1 domain containing 3
External IDs	OMIM: 609293; MGI: 2142186; HomoloGene: 28061; GeneCards: SPRED3; OMA:SPRED3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.2 Start 38,388,421 bp [1] End 38,399,587 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 B1 Start 28,858,254 bp [2] End 28,869,836 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland lateral nuclear group of thalamus vena cava external globus pallidus right ventricle pars reticulata Skeletal muscle tissue of rectus abdominis body of tongue pons subthalamic nucleus Top expressed in visual cortex primary visual cortex superior frontal gyrus tail of embryo spermatid neural layer of retina dentate gyrus of hippocampal formation granule cell lumbar subsegment of spinal cord ventricular zone genital tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function protein kinase binding Cellular component membrane Biological process multicellular organism development regulation of signal transduction negative regulation of peptidyl-threonine phosphorylation positive regulation of DNA damage response, signal transduction by p53 class mediator regulation of protein deacetylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 399473 101809 Ensembl ENSG00000188766 ENSMUSG00000037239 UniProt Q2MJR0 Q6P6N5 RefSeq (mRNA) NM_001039616 NM_001042522 NM_001394336 NM_001394337 NM_001394338 NM_182927 RefSeq (protein) NP_001035987 NP_891557 Location (UCSC) Chr 19: 38.39 – 38.4 Mb Chr 7: 28.86 – 28.87 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sprouty-related, EVH1 domain-containing protein 3 also known as Spread-3 is a protein that in humans is encoded by the SPRED3 gene. ^[5]

Spread-3 is a member of the Sprouty (see SPRY1/SPRED) family of proteins that regulate growth factor-induced activation of the MAP kinase cascade. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000188766 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037239 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: sprouty-related".
6. Nonami A, Kato R, Taniguchi K, Yoshiga D, Taketomi T, Fukuyama S, Harada M, Sasaki A, Yoshimura A (December 2004). "Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells". The Journal of Biological Chemistry. 279 (50): 52543–51. doi: 10.1074/jbc.M405189200 . PMID   15465815.

Further reading

• Kato R, Nonami A, Taketomi T, Wakioka T, Kuroiwa A, Matsuda Y, Yoshimura A (March 2003). "Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation". Biochemical and Biophysical Research Communications. 302 (4): 767–72. doi:10.1016/S0006-291X(03)00259-6. PMID   12646235.
• Mizoguchi M, Nutt CL, Louis DN (February 2004). "Mutation analysis of CBL-C and SPRED3 on 19q in human glioblastoma". Neurogenetics. 5 (1): 81–2. doi:10.1007/s10048-003-0164-x. PMID   14618415. S2CID   35025882.
• King JA, Corcoran NM, D'Abaco GM, Straffon AF, Smith CT, Poon CL, Buchert M, I S, Hall NE, Lock P, Hovens CM (April 2006). "Eve-3: a liver enriched suppressor of Ras/MAPK signaling". Journal of Hepatology. 44 (4): 758–67. doi: 10.1016/j.jhep.2005.10.031 . PMID   16478641.
• Lock P, I ST, Straffon AF, Schieb H, Hovens CM, Stylli SS (December 2006). "Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination". Biochemical and Biophysical Research Communications. 351 (4): 1018–23. doi:10.1016/j.bbrc.2006.10.150. PMID   17094949.