SPRR1A

SPRR1A
Identifiers
Aliases	SPRR1A , SPRK, small proline rich protein 1A
External IDs	OMIM: 182265 MGI: 106660 HomoloGene: 105698 GeneCards: SPRR1A
Gene location (Human)
Chr.	Chromosome 1 (human)
End	152,985,500 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	92,393,202 bp
RNA expression pattern
	Top expressed in
	esophagus; ; cavity of mouth; ; gums; ; squamous epithelium;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity ; GO:0001948 protein binding ; structural molecule activity ; structural constituent of skin epidermis ;
Cellular component	cytoplasm ; cornified envelope ; cytosol ;
Biological process	peptide cross-linking ; keratinization ; keratinocyte differentiation ; epidermis development ; cornification ;
	Sources:Amigo / QuickGO
Orthologs
	6698
	20753
	ENSG00000169474
	ENSMUSG00000050359
	P35321
	Q62266
	NM_005987 ; NM_001199828
	NM_009264
	NP_001186757 ; NP_005978
	NP_033290
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 09, 2022

Cornifin-A is a protein that in humans is encoded by the SPRR1A gene.^[5]^[6]

Related Research Articles

Keratin 1 is a member of the keratin family. It is specifically expressed in the spinous and granular layers of the epidermis with family member keratin 10. Mutations in this gene have been associated with the variants of bullous congenital ichthyosiform erythroderma in which the palms and soles of the feet are affected.

C-X-C motif chemokine 11 (CXCL11) is a protein that in humans is encoded by the CXCL11 gene.

Protein-glutamine gamma-glutamyltransferase K is a transglutaminase enzyme that in humans is encoded by the TGM1 gene.

Keratohyalin is a protein structure found in cytoplasmic granules of the keratinocytes in the stratum granulosum of the epidermis. Keratohyalin granules (KHG) mainly consist of keratin, profilaggrin, loricrin and trichohyalin proteins which contribute to cornification or keratinization, the process of the formation of epidermal cornified cell envelope. During the keratinocyte differentiation, these granules maturate and expand in size, which leads to the conversion of keratin tonofilaments into a homogenous keratin matrix, an important step in cornification.

Dystonin(DST), also known as bullous pemphigoid antigen 1 (BPAG1), isoforms 1/2/3/4/5/8, is a protein that in humans is encoded by the DST gene.

Cystatin-A is a protein that in humans is encoded by the CSTA gene.

Involucrin is a protein component of human skin and in humans is encoded by the IVL gene. In binding the protein loricrin, involucrin contributes to the formation of a cell envelope that protects corneocytes in the skin.

Protein-glutamine gamma-glutamyltransferase E is an enzyme that in humans is encoded by the TGM3 gene.

Periplakin is a protein that in humans is encoded by the PPL gene.

Small proline-rich protein 3 is a protein that in humans is encoded by the SPRR3 gene, which is found within the epidermal differentiation complex (EDC).

Loricrin is a protein that in humans is encoded by the LOR gene.

SH3 and multiple ankyrin repeat domains protein 2 is a protein that in humans is encoded by the SHANK2 gene. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined.

Envoplakin is a protein that in humans is encoded by the EVPL gene.

Cornifin-B is a protein that in humans is encoded by the SPRR1B gene.

Proline-rich AKT1 substrate 1 (PRAS) is a protein that in humans is encoded by the AKT1S1 gene.

Periphilin-1 is a protein that in humans is encoded by the PPHLN1 gene.

Small proline-rich protein 2A is a protein that in humans is encoded by the SPRR2A gene.

Sciellin is a protein that in humans is encoded by the SCEL gene.

Trichohyalin is a protein that in mammals is encoded by the TCHH gene.

The epidermal differentiation complex (EDC) is a gene complex comprising over fifty genes encoding proteins involved in the terminal differentiation and cornification of keratinocytes, the primary cell type of the epidermis. In humans, the complex is located on a 1.9 Mbp stretch within chromosome 1q21. The proteins encoded by EDC genes are closely related in terms of function, and evolutionarily they belong to three distinct gene families: the cornified envelope precursor family, the S100 protein family and the S100 fused type protein (SFTP) family.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000169474 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050359 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gibbs S, Fijneman R, Wiegant J, van Kessel AG, van De Putte P, Backendorf C (June 1993). "Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins". Genomics. 16 (3): 630–7. doi:10.1006/geno.1993.1240. PMID 8325635.
↑ "Entrez Gene: SPRR1A small proline-rich protein 1A".

Greco MA, Lorand L, Lane WS, Baden HP, Parameswaran KN, Kvedar JC (February 1995). "The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation". The Journal of Investigative Dermatology. 104 (2): 204–10. doi: 10.1111/1523-1747.ep12612759 . PMID 7829876.
Robinson PA, Marley JJ, High AS, Hume WJ (March 1994). "Differential expression of protease inhibitor and small proline-rich protein genes between normal human oral tissue and odontogenic keratocysts". Archives of Oral Biology. 39 (3): 251–9. doi:10.1016/0003-9969(94)90051-5. PMID 8018055.
Fujimoto W, Nakanishi G, Arata J, Jetten AM (February 1997). "Differential expression of human cornifin alpha and beta in squamous differentiating epithelial tissues and several skin lesions". The Journal of Investigative Dermatology. 108 (2): 200–4. doi: 10.1111/1523-1747.ep12334240 . PMID 9008234.
Robinson NA, Lapic S, Welter JF, Eckert RL (May 1997). "S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes". The Journal of Biological Chemistry. 272 (18): 12035–46. doi: 10.1074/jbc.272.18.12035 . PMID 9115270.
Reddy SP, Konkin T, Wu R (December 1998). "Structure and organization of the genes encoding mouse small proline-rich proteins, mSPRR1A and 1B". Gene. 224 (1–2): 59–66. doi:10.1016/S0378-1119(98)00507-1. PMID 9931436.
Candi E, Tarcsa E, Idler WW, Kartasova T, Marekov LN, Steinert PM (March 1999). "Transglutaminase cross-linking properties of the small proline-rich 1 family of cornified cell envelope proteins. Integration with loricrin". The Journal of Biological Chemistry. 274 (11): 7226–37. doi: 10.1074/jbc.274.11.7226 . PMID 10066784.
Lee CH, Marekov LN, Kim S, Brahim JS, Park MH, Steinert PM (July 2000). "Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes". FEBS Letters. 477 (3): 268–72. doi: 10.1016/S0014-5793(00)01806-8 . PMID 10908733.
Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Cabral A, Voskamp P, Cleton-Jansen AM, South A, Nizetic D, Backendorf C (June 2001). "Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function". The Journal of Biological Chemistry. 276 (22): 19231–7. doi: 10.1074/jbc.M100336200 . PMID 11279051.
Bonilla IE, Tanabe K, Strittmatter SM (February 2002). "Small proline-rich repeat protein 1A is expressed by axotomized neurons and promotes axonal outgrowth". The Journal of Neuroscience. 22 (4): 1303–15. doi:10.1523/JNEUROSCI.22-04-01303.2002. PMC 6757578 . PMID 11850458.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000169474 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050359 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8325635-5] Gibbs S, Fijneman R, Wiegant J, van Kessel AG, van De Putte P, Backendorf C (June 1993). "Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins". Genomics. 16 (3): 630–7. doi:10.1006/geno.1993.1240. PMID 8325635.

[entrez-6] "Entrez Gene: SPRR1A small proline-rich protein 1A".

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SPRR1A

Related Research Articles

References

Further reading