SPRR2A

SPRR2A
Identifiers
Aliases	SPRR2A , small proline rich protein 2A
External IDs	OMIM: 182267; MGI: 1330343; HomoloGene: 130544; GeneCards: SPRR2A; OMA:SPRR2A - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q21.3 Start 153,056,120 bp [1] End 153,057,512 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3 F1|3 40.14 cM Start 92,292,992 bp [2] End 92,294,631 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell gums gingival epithelium body of tongue amniotic fluid mucosa of pharynx oral cavity human penis nasal epithelium vulva Top expressed in gastrula decidua cervix skin of back lip skin of abdomen skin of external ear umbilical cord sexually immature organism esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding structural molecule activity Cellular component cytoplasm cornified envelope cytosol Biological process peptide cross-linking keratinization keratinocyte differentiation epidermis development cornification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6700 20762 Ensembl ENSG00000241794 ENSMUSG00000046259 UniProt P35326 O70559 RefSeq (mRNA) NM_005988 NM_011474 RefSeq (protein) NP_005979 NP_035604 Location (UCSC) Chr 1: 153.06 – 153.06 Mb Chr 3: 92.29 – 92.29 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Small proline-rich protein 2A is a protein that in humans is encoded by the SPRR2A gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000241794 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046259 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gibbs S, Fijneman R, Wiegant J, van Kessel AG, van De Putte P, Backendorf C (Aug 1993). "Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins". Genomics. 16 (3): 630–7. doi:10.1006/geno.1993.1240. PMID   8325635.
6. "Entrez Gene: SPRR2A small proline-rich protein 2A".

Further reading

• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Tong L, Corrales RM, Chen Z, et al. (2006). "Expression and Regulation of Cornified Envelope Proteins in Human Corneal Epithelium". Invest. Ophthalmol. Vis. Sci. 47 (5): 1938–46. doi:10.1167/iovs.05-1129. PMC   2906387 . PMID   16639001.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Hong SH, Nah HY, Lee JY, et al. (2004). "Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus". Mol. Cells. 17 (3): 477–84. doi: 10.1016/S1016-8478(23)13069-X . PMID   15232223.
• Cabral A, Fischer DF, Vermeij WP, Backendorf C (2003). "Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation". J. Biol. Chem. 278 (20): 17792–9. doi: 10.1074/jbc.M300508200 . hdl: 1887/50054 . PMID   12624109.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC   16267 . PMID   10737800.
• Fischer DF, van Drunen CM, Winkler GS, et al. (1999). "Involvement of a nuclear matrix association region in the regulation of the SPRR2A keratinocyte terminal differentiation marker". Nucleic Acids Res. 26 (23): 5288–94. doi:10.1093/nar/26.23.5288. PMC   147987 . PMID   9826750.
• Steinert PM, Marekov LN (1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope". J. Biol. Chem. 272 (3): 2021–30. doi: 10.1074/jbc.272.3.2021 . PMID   8999895.
• Fischer DF, Gibbs S, van De Putte P, Backendorf C (1996). "Interdependent transcription control elements regulate the expression of the SPRR2A gene during keratinocyte terminal differentiation". Mol. Cell. Biol. 16 (10): 5365–74. doi:10.1128/MCB.16.10.5365. PMC   231535 . PMID   8816448.
• Gibbs S, Lohman F, Teubel W, et al. (1990). "Characterization of the human spr2 promoter: induction after UV irradiation or TPA treatment and regulation during differentiation of cultured primary keratinocytes". Nucleic Acids Res. 18 (15): 4401–7. doi:10.1093/nar/18.15.4401. PMC   331257 . PMID   2388825.