SPZ1

SPZ1
Identifiers
Aliases	SPZ1 , NYD-TSP1, PPP1R148, spermatogenic leucine zipper 1, CILD38
External IDs	OMIM: 618068; MGI: 1930801; HomoloGene: 49934; GeneCards: SPZ1; OMA:SPZ1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q14.1 Start 80,319,625 bp [1] End 80,321,842 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 C3 Start 92,711,144 bp [2] End 92,712,680 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm testicle left testis right testis gonad tail of epididymis endometrium human musculoskeletal system muscular system gallbladder Top expressed in seminiferous tubule spermatid spermatocyte morula zygote islet of Langerhans white adipose tissue epididymis striated muscle tissue skeletal muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding DNA-binding transcription factor activity Cellular component cytoplasm nucleus Biological process transcription, DNA-templated regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84654 79401 Ensembl ENSG00000164299 ENSMUSG00000046957 UniProt Q9BXG8 Q99MY0 RefSeq (mRNA) NM_032567 NM_030237 RefSeq (protein) NP_115956 NP_084513 Location (UCSC) Chr 5: 80.32 – 80.32 Mb Chr 13: 92.71 – 92.71 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Spermatogenic leucine zipper protein 1 is a protein that in humans is encoded by the SPZ1 gene. ^{[5] [6] [7] [8] [9] [10]}

References

1. GRCh38: Ensembl release 89: ENSG00000164299 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046957 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hsu SH, Shyu HW, Hsieh-Li HM, Li H (Feb 2001). "Spz1, a novel bHLH-Zip protein, is specifically expressed in testis". Mech Dev. 100 (2): 177–87. doi:10.1016/S0925-4773(00)00513-X. PMID   11165476. S2CID   17206805.
6. Sha JH, Zhou ZM, Li JM, Lin M, Zhu H, Zhu H, Zhou YD, Wang LL, Wang YQ, Zhou KY (Jun 2003). "Expression of a novel bHLH-Zip gene in human testis". Asian J Androl. 5 (2): 83–8. PMID   12778315.
7. Hrabchak C, Varmuza S (Aug 2004). "Identification of the spermatogenic zip protein Spz1 as a putative protein phosphatase-1 (PP1) regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis". J Biol Chem. 279 (35): 37079–86. doi: 10.1074/jbc.M403710200 . PMID   15226296.
8. Horowitz E, Zhang Z, Jones BH, Moss SB, Ho C, Wood JR, Wang X, Sammel MD, Strauss JF 3rd (Apr 2005). "Patterns of expression of sperm flagellar genes: early expression of genes encoding axonemal proteins during the spermatogenic cycle and shared features of promoters of genes encoding central apparatus proteins". Mol Hum Reprod. 11 (4): 307–17. doi:10.1093/molehr/gah163. PMID   15829580.
9. Hsu SH, Hsieh-Li HM, Huang HY, Huang PH, Li H (May 2005). "bHLH-zip transcription factor Spz1 mediates mitogen-activated protein kinase cell proliferation, transformation, and tumorigenesis". Cancer Res. 65 (10): 4041–50. doi: 10.1158/0008-5472.CAN-04-3658 . PMID   15899793.
10. "Entrez Gene: SPZ1 spermatogenic leucine zipper 1".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5" (PDF). Nature. 431 (7006): 268–74. Bibcode:2004Natur.431..268S. doi: 10.1038/nature02919 . PMID   15372022. S2CID   4373053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.