SRCAP

SRCAP
Identifiers
Aliases	SRCAP , DOMO1, EAF1, FLHS, SWR1, Snf2-related CREBBP activator protein, Snf2 related CREBBP activator protein, DEHMBA
External IDs	OMIM: 611421 MGI: 2444036 HomoloGene: 38213 GeneCards: SRCAP
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p11.2 Start 30,698,209 bp [1] End 30,741,409 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F3 Start 127,111,155 bp [2] End 127,160,391 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve stromal cell of endometrium appendix gastric mucosa gastrocnemius muscle bone marrow cells right lobe of thyroid gland Left adrenal gland popliteal artery body of stomach Top expressed in lip superior frontal gyrus yolk sac cerebellar cortex otolith organ utricle aortic valve ascending aorta esophagus neural tube More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding transcription coactivator activity nucleotide binding protein binding ATP binding hydrolase activity helicase activity histone acetyltransferase activity ATPase activity histone binding Cellular component perinuclear region of cytoplasm Golgi apparatus nucleus nucleoplasm nuclear body protein-containing complex Swr1 complex Biological process regulation of transcription by RNA polymerase II viral process regulation of transcription, DNA-templated transcription, DNA-templated histone acetylation chromatin organization positive regulation of nucleic acid-templated transcription chromatin remodeling histone exchange Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10847 100043597 Ensembl ENSG00000080603 ENSMUSG00000053877 UniProt Q6ZRS2 n/a RefSeq (mRNA) NM_006662 NM_001033881 NM_001304266 NM_175144 NM_178800 RefSeq (protein) NP_006653 n/a Location (UCSC) Chr 16: 30.7 – 30.74 Mb Chr 7: 127.11 – 127.16 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Helicase SRCAP is an enzyme that in humans is encoded by the SRCAP gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000080603 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053877 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Johnston H, Kneer J, Chackalaparampil I, Yaciuk P, Chrivia J (Jul 1999). "Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein". J Biol Chem. 274 (23): 16370–6. doi: 10.1074/jbc.274.23.16370 . PMID   10347196.
6. Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Sep 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi: 10.1093/dnares/4.2.141 . PMID   9205841.
7. "Entrez Gene: SRCAP Snf2-related CBP activator protein".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Ghosh AK, Majumder M, Steele R, et al. (2000). "Hepatitis C virus NS5A protein modulates transcription through a novel cellular transcription factor SRCAP". J. Biol. Chem. 275 (10): 7184–8. doi: 10.1074/jbc.275.10.7184 . PMID   10702287.
• Xu X, Chackalaparampil I, Monroy MA, et al. (2001). "Adenovirus DNA binding protein interacts with the SNF2-related CBP activator protein (SrCap) and inhibits SrCap-mediated transcription". J. Virol. 75 (21): 10033–40. doi:10.1128/JVI.75.21.10033-10040.2001. PMC   114578 . PMID   11581372.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Monroy MA, Schott NM, Cox L, et al. (2004). "SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1". Mol. Endocrinol. 17 (12): 2519–28. doi: 10.1210/me.2003-0208 . PMID   14500758.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. Biol. Chem. 280 (14): 13665–70. doi: 10.1074/jbc.M500001200 . PMID   15647280.
• Eissenberg JC, Wong M, Chrivia JC (2005). "Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway". Mol. Cell. Biol. 25 (15): 6559–69. doi:10.1128/MCB.25.15.6559-6569.2005. PMC   1190335 . PMID   16024792.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Ruhl DD, Jin J, Cai Y, et al. (2006). "Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes". Biochemistry. 45 (17): 5671–7. doi:10.1021/bi060043d. PMID   16634648.
• Cai Y, Jin J, Gottschalk AJ, et al. (2007). "Purification and assay of the human INO80 and SRCAP chromatin remodeling complexes". Methods. 40 (4): 312–7. doi:10.1016/j.ymeth.2006.06.023. PMC   3092633 . PMID   17101442.
• Wong MM, Cox LK, Chrivia JC (2007). "The chromatin remodeling protein, SRCAP, is critical for deposition of the histone variant H2A.Z at promoters". J. Biol. Chem. 282 (36): 26132–9. doi: 10.1074/jbc.M703418200 . PMID   17617668.

External links

• OMIM entry on Floating-Harbor syndrome and SRCAP