SRPK2

SRPK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2X7G
Identifiers
Aliases	SRPK2 , SFRSK2, SRSF protein kinase 2
External IDs	OMIM: 602980; MGI: 1201408; HomoloGene: 101663; GeneCards: SRPK2; OMA:SRPK2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q22.3 Start 105,110,704 bp [1] End 105,399,308 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5 A3|5 10.36 cM Start 23,503,264 bp [2] End 23,684,617 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm Pons secondary oocyte middle temporal gyrus lateral nuclear group of thalamus entorhinal cortex Parietal Lobe postcentral gyrus left testis right testis Top expressed in Rostral migratory stream medial dorsal nucleus medial geniculate nucleus ventral tegmental area spermatid lateral geniculate nucleus seminiferous tubule pontine nuclei medial vestibular nucleus globus pallidus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity 14-3-3 protein binding kinase activity protein serine/threonine kinase activity protein binding ATP binding magnesium ion binding RNA binding Cellular component cytoplasm nucleoplasm nucleolus nucleus cytosol Biological process cell differentiation intracellular signal transduction nuclear speck organization phosphorylation mRNA processing regulation of mRNA splicing, via spliceosome protein phosphorylation spliceosomal complex assembly positive regulation of neuron apoptotic process negative regulation of viral genome replication positive regulation of gene expression positive regulation of cell cycle angiogenesis RNA splicing positive regulation of cell population proliferation positive regulation of viral genome replication innate immune response regulation of gene expression regulation of mRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6733 20817 Ensembl ENSG00000135250 ENSMUSG00000062604 UniProt P78362 O54781 RefSeq (mRNA) NM_001278273 NM_182691 NM_182692 NM_001350738 NM_001350739 NM_001350740 NM_001350741 NM_001350742 NM_001350743 NM_001350744 NM_001350745 NM_001350746 NM_009274 NM_001359172 NM_001359173 NM_001359174 NM_001359175 NM_001359176 RefSeq (protein) NP_001265202 NP_872633 NP_872634 NP_001337667 NP_001337668 NP_001337669 NP_001337670 NP_001337671 NP_001337672 NP_001337673 NP_001337674 NP_001337675 NP_033300 NP_001346101 NP_001346102 NP_001346103 NP_001346104 NP_001346105 NP_001394425 NP_001394427 NP_001394428 NP_001394429 NP_001394430 NP_001394431 NP_001394432 NP_001394433 NP_001394434 NP_001394435 NP_001394436 NP_001394437 NP_001394438 NP_001394439 NP_001394440 NP_001394441 NP_001394442 NP_001394443 NP_001394444 NP_001394445 NP_001394446 NP_001394447 NP_001394448 NP_001394449 NP_001394450 NP_001394451 NP_001394452 Location (UCSC) Chr 7: 105.11 – 105.4 Mb Chr 5: 23.5 – 23.68 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase SRPK2 is an enzyme that in humans is encoded by the SRPK2 gene. ^{[5] [6] [7]}

Interactions

SRPK2 has been shown to interact with:

• ASF/SF2 ^{[6] [8] [9]} and
• U2AF2. ^{[6] [10]}

References

1. GRCh38: Ensembl release 89: ENSG00000135250 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062604 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gui JF, Lane WS, Fu XD (Jul 1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. Bibcode:1994Natur.369..678G. doi:10.1038/369678a0. PMID   8208298. S2CID   4275539. Archived from the original on 2020-12-03. Retrieved 2019-12-13.
6. Wang HY, Lin W, Dyck JA, Yeakley JM, Songyang Z, Cantley LC, Fu XD (Mar 1998). "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells". J Cell Biol. 140 (4): 737–50. doi:10.1083/jcb.140.4.737. PMC   2141757 . PMID   9472028.
7. "Entrez Gene: SRPK2 SFRS protein kinase 2".
8. Umehara H, Nishii Y, Morishima M, Kakehi Y, Kioka N, Amachi T, Koizumi J, Hagiwara M, Ueda K (Feb 2003). "Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A". Biochem. Biophys. Res. Commun. 301 (2): 324–9. doi:10.1016/s0006-291x(02)03017-6. PMID   12565863.
9. Koizumi J, Okamoto Y, Onogi H, Mayeda A, Krainer AR, Hagiwara M (Apr 1999). "The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs)". J. Biol. Chem. 274 (16): 11125–31. doi: 10.1074/jbc.274.16.11125 . PMID   10196197.
10. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

Further reading

• Bedford MT, Chan DC, Leder P (1997). "FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands". EMBO J. 16 (9): 2376–83. doi:10.1093/emboj/16.9.2376. PMC   1169838 . PMID   9171351.
• Kuroyanagi N, Onogi H, Wakabayashi T, Hagiwara M (1998). "Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles". Biochem. Biophys. Res. Commun. 242 (2): 357–64. doi:10.1006/bbrc.1997.7913. PMID   9446799.
• Koizumi J, Okamoto Y, Onogi H, Mayeda A, Krainer AR, Hagiwara M (1999). "The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs)". J. Biol. Chem. 274 (16): 11125–31. doi: 10.1074/jbc.274.16.11125 . PMID   10196197.
• Daub H, Blencke S, Habenberger P, Kurtenbach A, Dennenmoser J, Wissing J, Ullrich A, Cotten M (2002). "Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein". J. Virol. 76 (16): 8124–37. doi:10.1128/JVI.76.16.8124-8137.2002. PMC   155132 . PMID   12134018.
• Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID   15144186.
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Zheng Y, Fu XD, Ou JH (2005). "Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein". Virology. 342 (1): 150–8. doi:10.1016/j.virol.2005.07.030. PMID   16122776.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.