SRPK2

SRPK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2X7G
Identifiers
Aliases	SRPK2 , SFRSK2, SRSF protein kinase 2
External IDs	OMIM: 602980 MGI: 1201408 HomoloGene: 101663 GeneCards: SRPK2
Gene location (Human)
Chr.	Chromosome 7 (human)
End	105,399,308 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	23,684,617 bp
RNA expression pattern
	Top expressed in
	sperm; ; pons; ; secondary oocyte; ; middle temporal gyrus; ; entorhinal cortex; ; parietal lobe; ; postcentral gyrus; ; external globus pallidus; ; ventral tegmental area; ; Brodmann area 23;
	Top expressed in
	medial dorsal nucleus; ; medial geniculate nucleus; ; ventral tegmental area; ; spermatid; ; lateral geniculate nucleus; ; seminiferous tubule; ; pontine nuclei; ; medial vestibular nucleus; ; globus pallidus; ; lateral hypothalamus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity ; nucleotide binding ; protein kinase activity ; 14-3-3 protein binding ; kinase activity ; protein serine/threonine kinase activity ; protein binding ; ATP binding ; magnesium ion binding ; RNA binding ;
Cellular component	cytoplasm ; nucleoplasm ; nucleolus ; nucleus ; cytosol ;
Biological process	cell differentiation ; intracellular signal transduction ; nuclear speck organization ; phosphorylation ; mRNA processing ; regulation of mRNA splicing, via spliceosome ; protein phosphorylation ; spliceosomal complex assembly ; positive regulation of neuron apoptotic process ; negative regulation of viral genome replication ; positive regulation of gene expression ; positive regulation of cell cycle ; angiogenesis ; RNA splicing ; positive regulation of cell population proliferation ; positive regulation of viral genome replication ; innate immune response ; regulation of gene expression ; regulation of mRNA processing ;
	Sources:Amigo / QuickGO
Orthologs
	6733
	20817
	ENSG00000135250
	ENSMUSG00000062604
	P78362
	O54781
NM_001278273 ; NM_182691 ; NM_182692 ; NM_001350738 ; NM_001350739 ;
	NM_001350740 ; NM_001350741 ; NM_001350742 ; NM_001350743 ; NM_001350744 ; NM_001350745 ; NM_001350746 Contents Interactions ; References ; Further reading ;
NM_009274 ; NM_001359172 ; NM_001359173 ; NM_001359174 ; NM_001359175 ;
	NM_001359176
NP_001265202 ; NP_872633 ; NP_872634 ; NP_001337667 ; NP_001337668 ;
	NP_001337669 ; NP_001337670 ; NP_001337671 ; NP_001337672 ; NP_001337673 ; NP_001337674 ; NP_001337675
NP_033300 ; NP_001346101 ; NP_001346102 ; NP_001346103 ; NP_001346104 ;
	NP_001346105 ; NP_001394425 ; NP_001394427 ; NP_001394428 ; NP_001394429 ; NP_001394430 ; NP_001394431 ; NP_001394432 ; NP_001394433 ; NP_001394434 ; NP_001394435 ; NP_001394436 ; NP_001394437 ; NP_001394438 ; NP_001394439 ; NP_001394440 ; NP_001394441 ; NP_001394442 ; NP_001394443 ; NP_001394444 ; NP_001394445 ; NP_001394446 ; NP_001394447 ; NP_001394448 ; NP_001394449 ; NP_001394450 ; NP_001394451 ; NP_001394452
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 04, 2023

Serine/threonine-protein kinase SRPK2 is an enzyme that in humans is encoded by the SRPK2 gene.^[5]^[6]^[7]

Interactions

SRPK2 has been shown to interact with:

ASF/SF2 ^[6]^[8]^[9] and
U2AF2.^[6]^[10]

Related Research Articles

SR proteins are a conserved family of proteins involved in RNA splicing. SR proteins are named because they contain a protein domain with long repeats of serine and arginine amino acid residues, whose standard abbreviations are "S" and "R" respectively. SR proteins are ~200-600 amino acids in length and composed of two domains, the RNA recognition motif (RRM) region and the RS domain. SR proteins are more commonly found in the nucleus than the cytoplasm, but several SR proteins are known to shuttle between the nucleus and the cytoplasm.

Splicing factor U2AF 65 kDa subunit is a protein that in humans is encoded by the U2AF2 gene.

snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein that in humans is encoded by the SNRNP70 gene. snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming the U1snRNP a core component of the spliceosome. The U1-70K protein and other components of the spliceosome complex form detergent-insoluble aggregates in both sporadic and familial human cases of Alzheimer's disease. U1-70K co-localizes with Tau in neurofibrillary tangles in Alzheimer's disease.

Mitogen-activated protein kinase kinase kinase 11 is an enzyme that in humans is encoded by the MAP3K11 gene.

Serine/threonine-protein kinase N1 is an enzyme that in humans is encoded by the PKN1 gene.

Splicing factor U2AF 35 kDa subunit is a protein that in humans is encoded by the U2AF1 gene.

Ribosomal protein S6 kinase alpha-5 is an enzyme that in humans is encoded by the RPS6KA5 gene. This kinase, together with RPS6KA4, are thought to mediate the phosphorylation of histone H3, linked to the expression of immediate early genes.

Serine/arginine-Rich Splicing Factor (SRSF) protein kinase-1 SRPK1 is an enzyme that in humans is encoded by the SRPK1 gene.

Splicing factor, arginine/serine-rich 5 is a protein that in humans is encoded by the SFRS5 gene.

Dual specificity protein kinase CLK1 is an enzyme that in humans is encoded by the CLK1 gene.

Mitogen-activated protein kinase 12 is an enzyme that in humans is encoded by the MAP3K12 gene.

Cyclin dependent kinase 13 is an enzyme that in humans is encoded by the CDK13 gene.

MAP/microtubule affinity-regulating kinase 3 is an enzyme that in humans is encoded by the MARK3 gene.

Serine/threonine-protein kinase PRP4 homolog is an enzyme that in humans is encoded by the PRPF4B gene.

Dual specificity tyrosine-phosphorylation-regulated kinase 1B is an enzyme that in humans is encoded by the DYRK1B gene.

Mitogen-activated protein kinase 6 is an enzyme that in humans is encoded by the MAPK6 gene.

Serine/threonine protein kinase MST4, also known as mammalian STE20-like protein kinase 4 (MST-4), is a protein that in humans is encoded by the MST4 gene.

Dual specificity testis-specific protein kinase 1 is an enzyme that in humans is encoded by the TESK1 gene.

cGMP-dependent protein kinase 1, alpha isozyme is an enzyme that in humans is encoded by the PRKG1 gene.

Serine/arginine-rich splicing factor 1 (SRSF1) also known as alternative splicing factor 1 (ASF1), pre-mRNA-splicing factor SF2 (SF2) or ASF1/SF2 is a protein that in humans is encoded by the SRSF1 gene. ASF/SF2 is an essential sequence specific splicing factor involved in pre-mRNA splicing. SRSF1 is the gene that codes for ASF/SF2 and is found on chromosome 17. The resulting splicing factor is a protein of approximately 33 kDa. ASF/SF2 is necessary for all splicing reactions to occur, and influences splice site selection in a concentration-dependent manner, resulting in alternative splicing. In addition to being involved in the splicing process, ASF/SF2 also mediates post-splicing activities, such as mRNA nuclear export and translation.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000135250 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000062604 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gui JF, Lane WS, Fu XD (Jul 1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. Bibcode:1994Natur.369..678G. doi:10.1038/369678a0. PMID 8208298. S2CID 4275539. Archived from the original on 2020-12-03. Retrieved 2019-12-13.
1 2 3 Wang HY, Lin W, Dyck JA, Yeakley JM, Songyang Z, Cantley LC, Fu XD (Mar 1998). "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells". J Cell Biol. 140 (4): 737–50. doi:10.1083/jcb.140.4.737. PMC 2141757 . PMID 9472028.
↑ "Entrez Gene: SRPK2 SFRS protein kinase 2".
↑ Umehara H, Nishii Y, Morishima M, Kakehi Y, Kioka N, Amachi T, Koizumi J, Hagiwara M, Ueda K (Feb 2003). "Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A". Biochem. Biophys. Res. Commun. 301 (2): 324–9. doi:10.1016/s0006-291x(02)03017-6. PMID 12565863.
↑ Koizumi J, Okamoto Y, Onogi H, Mayeda A, Krainer AR, Hagiwara M (Apr 1999). "The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs)". J. Biol. Chem. 274 (16): 11125–31. doi: 10.1074/jbc.274.16.11125 . PMID 10196197.
↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Bedford MT, Chan DC, Leder P (1997). "FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands". EMBO J. 16 (9): 2376–83. doi:10.1093/emboj/16.9.2376. PMC 1169838 . PMID 9171351.
Kuroyanagi N, Onogi H, Wakabayashi T, Hagiwara M (1998). "Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles". Biochem. Biophys. Res. Commun. 242 (2): 357–64. doi:10.1006/bbrc.1997.7913. PMID 9446799.
Koizumi J, Okamoto Y, Onogi H, Mayeda A, Krainer AR, Hagiwara M (1999). "The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs)". J. Biol. Chem. 274 (16): 11125–31. doi: 10.1074/jbc.274.16.11125 . PMID 10196197.
Daub H, Blencke S, Habenberger P, Kurtenbach A, Dennenmoser J, Wissing J, Ullrich A, Cotten M (2002). "Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein". J. Virol. 76 (16): 8124–37. doi:10.1128/JVI.76.16.8124-8137.2002. PMC 155132 . PMID 12134018.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Zheng Y, Fu XD, Ou JH (2005). "Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein". Virology. 342 (1): 150–8. doi:10.1016/j.virol.2005.07.030. PMID 16122776.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000135250 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000062604 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8208298-5] Gui JF, Lane WS, Fu XD (Jul 1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. Bibcode:1994Natur.369..678G. doi:10.1038/369678a0. PMID 8208298. S2CID 4275539. Archived from the original on 2020-12-03. Retrieved 2019-12-13.

[pmid9472028-6] 1 2 3 Wang HY, Lin W, Dyck JA, Yeakley JM, Songyang Z, Cantley LC, Fu XD (Mar 1998). "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells". J Cell Biol. 140 (4): 737–50. doi:10.1083/jcb.140.4.737. PMC 2141757 . PMID 9472028.

[entrez-7] "Entrez Gene: SRPK2 SFRS protein kinase 2".

[pmid12565863-8] Umehara H, Nishii Y, Morishima M, Kakehi Y, Kioka N, Amachi T, Koizumi J, Hagiwara M, Ueda K (Feb 2003). "Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A". Biochem. Biophys. Res. Commun. 301 (2): 324–9. doi:10.1016/s0006-291x(02)03017-6. PMID 12565863.

[pmid10196197-9] Koizumi J, Okamoto Y, Onogi H, Mayeda A, Krainer AR, Hagiwara M (Apr 1999). "The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs)". J. Biol. Chem. 274 (16): 11125–31. doi: 10.1074/jbc.274.16.11125 . PMID 10196197.

[pmid16189514-10] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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SRPK2

Contents

Interactions

Related Research Articles

References

Further reading