SRPRB

SRPRB
Identifiers
Aliases	SRPRB , APMCF1, SRP receptor beta subunit, SRP receptor subunit beta, SR-beta
External IDs	OMIM: 616883 MGI: 102964 HomoloGene: 6332 GeneCards: SRPRB
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q22.1 Start 133,784,023 bp [1] End 133,825,772 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 F1 Start 103,065,231 bp [2] End 103,079,336 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas parotid gland islet of Langerhans tibia stromal cell of endometrium periodontal fiber pericardium corpus epididymis kidney tubule trachea Top expressed in saccule otic placode yolk sac spermatocyte renal corpuscle external carotid artery parotid gland internal carotid artery seminal vesicula molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding signal recognition particle binding GTP binding Cellular component endoplasmic reticulum membrane cytoplasmic microtubule cytoplasm integral component of membrane signal recognition particle receptor complex intracellular anatomical structure endoplasmic reticulum membrane Biological process IRE1-mediated unfolded protein response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 58477 20818 Ensembl ENSG00000144867 ENSMUSG00000032553 UniProt Q9Y5M8 P47758 RefSeq (mRNA) NM_021203 NM_001379313 NM_009275 RefSeq (protein) NP_067026 NP_001366242 NP_033301 Location (UCSC) Chr 3: 133.78 – 133.83 Mb Chr 9: 103.07 – 103.08 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Signal recognition particle receptor subunit beta is a protein that in humans is encoded by the SRPRB gene. ^{[5] [6] [7]}

The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000144867 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032553 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Miller JD, Tajima S, Lauffer L, Walter P (Mar 1995). "The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane". J Cell Biol. 128 (3): 273–82. doi:10.1083/jcb.128.3.273. PMC   2120348 . PMID   7844142.
6. Legate KR, Falcone D, Andrews DW (Oct 2000). "Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor beta-subunit to the alpha-subunit". J Biol Chem. 275 (35): 27439–46. doi: 10.1074/jbc.M003215200 . PMID   10859309.
7. "Entrez Gene: SRPRB signal recognition particle receptor, B subunit".

Further reading

• Bacher G, Pool M, Dobberstein B (1999). "The Ribosome Regulates the Gtpase of the β-Subunit of the Signal Recognition Particle Receptor". J. Cell Biol. 146 (4): 723–30. doi:10.1083/jcb.146.4.723. PMC   2156146 . PMID   10459008.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Yan W, Wang WL, Zhu F, et al. (2003). "Isolation of a novel member of small G protein superfamily and its expression in colon cancer". World J. Gastroenterol. 9 (8): 1719–24. doi: 10.3748/wjg.v9.i8.1719 . PMC   4611530 . PMID   12918107.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Li Q, Yan W, Cheng S, et al. (2007). "Introduction of G1 phase arrest in Human Hepatocellular carcinoma cells (HHCC) by APMCF1 gene transfection through the down-regulation of TIMP3 and up-regulation of the CDK inhibitors p21". Mol. Biol. Rep. 33 (4): 257–63. doi:10.1007/s11033-006-9007-9. PMID   17080297. S2CID   1871553.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.