SRPX

SRPX
Identifiers
Aliases	SRPX , DRS, ETX1, HEL-S-83p, SRPX1, sushi repeat containing protein, X-linked, sushi repeat containing protein X-linked
External IDs	OMIM: 300187; MGI: 1858306; HomoloGene: 4598; GeneCards: SRPX; OMA:SRPX - orthologs
Gene location (Human) Chr. X chromosome (human) [1] Band Xp11.4 Start 38,149,336 bp [1] End 38,220,924 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X A1.1 Start 9,904,216 bp [2] End 9,983,948 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pericardium left uterine tube right ventricle subcutaneous adipose tissue decidua parietal pleura tibia lower lobe of lung superficial temporal artery vena cava Top expressed in calvaria dermis molar lip umbilical cord lumbar spinal ganglion muscle of thigh lactiferous gland body of femur efferent ductule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding extracellular matrix structural constituent Cellular component autophagosome cell surface endoplasmic reticulum membrane collagen-containing extracellular matrix Biological process autophagy positive regulation of extrinsic apoptotic signaling pathway in absence of ligand phagolysosome assembly cell adhesion negative regulation of cell proliferation involved in contact inhibition response to endoplasmic reticulum stress Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8406 51795 Ensembl ENSG00000101955 ENSMUSG00000090084 UniProt P78539 Q9R0M3 RefSeq (mRNA) NM_006307 NM_001170750 NM_001170751 NM_001170752 NM_016911 NM_001365087 RefSeq (protein) NP_001164221 NP_001164222 NP_001164223 NP_006298 NP_058607 NP_001352016 Location (UCSC) Chr X: 38.15 – 38.22 Mb Chr X: 9.9 – 9.98 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sushi repeat-containing protein SRPX is a protein that in humans is encoded by the SRPX gene. ^{[5] [6] [7]} Bioinformatics analysis suggests the SRPX protein is a peroxiredoxin. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000101955 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000090084 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Meindl A, Carvalho MR, Herrmann K, Lorenz B, Achatz H, Lorenz B, Apfelstedt-Sylla E, Wittwer B, Ross M, Meitinger T (Jul 1996). "A gene (SRPX) encoding a sushi-repeat-containing protein is deleted in patients with X-linked retinitis pigmentosa". Hum Mol Genet. 4 (12): 2339–46. doi:10.1093/hmg/4.12.2339. PMID   8634708.
6. Dry KL, Aldred MA, Edgar AJ, Brown J, Manson FD, Ho MF, Prosser J, Hardwick LJ, Lennon AA, Thomson K, et al. (Jul 1996). "Identification of a novel gene, ETX1 from Xp21.1, a candidate gene for X-linked retintis pigmentosa (RP3)". Hum Mol Genet. 4 (12): 2347–53. doi:10.1093/hmg/4.12.2347. PMID   8634709.
7. "Entrez Gene: SRPX sushi-repeat-containing protein, X-linked".
8. Pawłowski K, Muszewska A, Lenart A, et al. (2010). "A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins". BMC Genomics. 11: 590. doi: 10.1186/1471-2164-11-590 . PMC   3091736 . PMID   20964819.

Further reading

• Nangaku M, Shankland SJ, Kurokawa K, et al. (1997). "Cloning of a new human gene with short consensus repeats using the EST database". Immunogenetics. 46 (2): 99–103. doi:10.1007/s002510050247. PMID   9162095. S2CID   23621385.
• Shimakage M, Takami K, Kodama K, et al. (2002). "Expression of drs mRNA in human lung adenocarcinomas". Hum. Pathol. 33 (6): 615–9. doi:10.1053/hupa.2002.125373. PMID   12152160.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Shin BK, Wang H, Yim AM, et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". J. Biol. Chem. 278 (9): 7607–16. doi: 10.1074/jbc.M210455200 . PMID   12493773.
• Mukaisho K, Suo M, Shimakage M, et al. (2003). "Down-regulation of drs mRNA in colorectal neoplasms". Jpn. J. Cancer Res. 93 (8): 888–93. doi:10.1111/j.1349-7006.2002.tb01334.x. PMC   5927109 . PMID   12716466.
• Kim CJ, Shimakage M, Kushima R, et al. (2003). "Down-regulation of drs mRNA in human prostate carcinomas". Hum. Pathol. 34 (7): 654–7. doi:10.1016/S0046-8177(03)00240-5. PMID   12874760.
• Tambe Y, Isono T, Haraguchi S, et al. (2004). "A novel apoptotic pathway induced by the drs tumor suppressor gene". Oncogene. 23 (17): 2977–87. doi: 10.1038/sj.onc.1207419 . PMID   15021917.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC   2665286 . PMID   15772651.