SRPX

SRPX
Identifiers
Aliases	SRPX , DRS, ETX1, HEL-S-83p, SRPX1, sushi repeat containing protein, X-linked, sushi repeat containing protein X-linked
External IDs	OMIM: 300187 MGI: 1858306 HomoloGene: 4598 GeneCards: SRPX
Gene location (Human)
Chr.	X chromosome (human)
End	38,220,924 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	9,983,948 bp
RNA expression pattern
	Top expressed in
	pericardium; ; left uterine tube; ; right ventricle; ; subcutaneous adipose tissue; ; parietal pleura; ; tibia; ; lower lobe of lung; ; superficial temporal artery; ; vena cava; ; left coronary artery;
	Top expressed in
	calvaria; ; dermis; ; molar; ; lip; ; belly cord; ; body of femur; ; uterus; ; skin of back; ; sciatic nerve; ; skin of abdomen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; extracellular matrix structural constituent ;
Cellular component	autophagosome ; cell surface ; endoplasmic reticulum ; membrane ; collagen-containing extracellular matrix ;
Biological process	autophagy ; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand ; phagolysosome assembly ; cell adhesion ; negative regulation of cell proliferation involved in contact inhibition ; response to endoplasmic reticulum stress ;
	Sources:Amigo / QuickGO
Orthologs
	8406
	51795
	ENSG00000101955
	ENSMUSG00000090084
	P78539
	Q9R0M3
	NM_006307 ; NM_001170750 ; NM_001170751 ; NM_001170752
	NM_016911 ; NM_001365087
	NP_001164221 ; NP_001164222 ; NP_001164223 ; NP_006298
	NP_058607 ; NP_001352016
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 05, 2022

Sushi repeat-containing protein SRPX is a protein that in humans is encoded by the SRPX gene.^[5]^[6]^[7] Bioinformatics analysis suggests the SRPX protein is a peroxiredoxin.^[8]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000101955 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000090084 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Meindl A, Carvalho MR, Herrmann K, Lorenz B, Achatz H, Lorenz B, Apfelstedt-Sylla E, Wittwer B, Ross M, Meitinger T (Jul 1996). "A gene (SRPX) encoding a sushi-repeat-containing protein is deleted in patients with X-linked retinitis pigmentosa". Hum Mol Genet. 4 (12): 2339–46. doi:10.1093/hmg/4.12.2339. PMID 8634708.
↑ Dry KL, Aldred MA, Edgar AJ, Brown J, Manson FD, Ho MF, Prosser J, Hardwick LJ, Lennon AA, Thomson K, et al. (Jul 1996). "Identification of a novel gene, ETX1 from Xp21.1, a candidate gene for X-linked retintis pigmentosa (RP3)". Hum Mol Genet. 4 (12): 2347–53. doi:10.1093/hmg/4.12.2347. PMID 8634709.
↑ "Entrez Gene: SRPX sushi-repeat-containing protein, X-linked".
↑ Pawłowski K, Muszewska A, Lenart A, et al. (2010). "A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins". BMC Genomics. 11: 590. doi:10.1186/1471-2164-11-590. PMC 3091736 . PMID 20964819.

Nangaku M, Shankland SJ, Kurokawa K, et al. (1997). "Cloning of a new human gene with short consensus repeats using the EST database". Immunogenetics. 46 (2): 99–103. doi:10.1007/s002510050247. PMID 9162095. S2CID 23621385.
Shimakage M, Takami K, Kodama K, et al. (2002). "Expression of drs mRNA in human lung adenocarcinomas". Hum. Pathol. 33 (6): 615–9. doi:10.1053/hupa.2002.125373. PMID 12152160.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Shin BK, Wang H, Yim AM, et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". J. Biol. Chem. 278 (9): 7607–16. doi: 10.1074/jbc.M210455200 . PMID 12493773.
Mukaisho K, Suo M, Shimakage M, et al. (2003). "Down-regulation of drs mRNA in colorectal neoplasms". Jpn. J. Cancer Res. 93 (8): 888–93. doi:10.1111/j.1349-7006.2002.tb01334.x. PMC 5927109 . PMID 12716466.
Kim CJ, Shimakage M, Kushima R, et al. (2003). "Down-regulation of drs mRNA in human prostate carcinomas". Hum. Pathol. 34 (7): 654–7. doi:10.1016/S0046-8177(03)00240-5. PMID 12874760.
Tambe Y, Isono T, Haraguchi S, et al. (2004). "A novel apoptotic pathway induced by the drs tumor suppressor gene". Oncogene. 23 (17): 2977–87. doi: 10.1038/sj.onc.1207419 . PMID 15021917.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286 . PMID 15772651.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000101955 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000090084 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8634708-5] Meindl A, Carvalho MR, Herrmann K, Lorenz B, Achatz H, Lorenz B, Apfelstedt-Sylla E, Wittwer B, Ross M, Meitinger T (Jul 1996). "A gene (SRPX) encoding a sushi-repeat-containing protein is deleted in patients with X-linked retinitis pigmentosa". Hum Mol Genet. 4 (12): 2339–46. doi:10.1093/hmg/4.12.2339. PMID 8634708.

[pmid8634709-6] Dry KL, Aldred MA, Edgar AJ, Brown J, Manson FD, Ho MF, Prosser J, Hardwick LJ, Lennon AA, Thomson K, et al. (Jul 1996). "Identification of a novel gene, ETX1 from Xp21.1, a candidate gene for X-linked retintis pigmentosa (RP3)". Hum Mol Genet. 4 (12): 2347–53. doi:10.1093/hmg/4.12.2347. PMID 8634709.

[entrez-7] "Entrez Gene: SRPX sushi-repeat-containing protein, X-linked".

[pmid20964819-8] Pawłowski K, Muszewska A, Lenart A, et al. (2010). "A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins". BMC Genomics. 11: 590. doi:10.1186/1471-2164-11-590. PMC 3091736 . PMID 20964819.

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SRPX

Related Research Articles

References

Further reading