SRXN1

SRXN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XW4, 1YZS, 2B6F, 2RII, 3CYI, 3HY2
Identifiers
Aliases	SRXN1 , C20orf139, Npn3, SRX, SRX1, sulfiredoxin 1
External IDs	OMIM: 617583 MGI: 104971 HomoloGene: 32722 GeneCards: SRXN1
Gene location (Human)
Chr.	Chromosome 20 (human)
End	653,200 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	151,953,296 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; Left adrenal gland; ; stromal cell of endometrium; ; left ventricle; ; gastrocnemius muscle; ; monocyte; ; body of stomach; ; dorsolateral prefrontal cortex; ; left lobe of thyroid gland; ; anterior pituitary;
	Top expressed in
	adrenal gland; ; ileum; ; jejunum; ; duodenum; ; pituitary gland; ; pontine nuclei; ; blood; ; lateral geniculate nucleus; ; ankle joint; ; adrenal medulla;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding ; oxidoreductase activity ; antioxidant activity ; ATP binding ; oxidoreductase activity, acting on a sulfur group of donors ; sulfiredoxin activity ; protein binding ;
Cellular component	cytoplasm ; cytosol ;
Biological process	cellular oxidant detoxification ; response to oxidative stress ; cellular response to oxidative stress ;
	Sources:Amigo / QuickGO
Orthologs
	140809
	76650
	ENSG00000271303
	ENSMUSG00000032802
	Q9BYN0
	Q9D975
	NM_080725
	NM_029688
	NP_542763
	NP_083964
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 05, 2023

Sulfiredoxin-1 is a protein that in humans is encoded by the SRXN1 gene.^[5]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000271303 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032802 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: SRXN1 sulfiredoxin 1 homolog (S. Cerevisiae)".

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. Bibcode:2001Sci...291.1304V. doi: 10.1126/science.1058040 . PMID 11181995.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Chang TS, Jeong W, Woo HA, et al. (2005). "Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine". J. Biol. Chem. 279 (49): 50994–1001. doi: 10.1074/jbc.M409482200 . PMID 15448164.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Woo HA, Jeong W, Chang TS, et al. (2005). "Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins". J. Biol. Chem. 280 (5): 3125–8. doi: 10.1074/jbc.C400496200 . PMID 15590625.
Jönsson TJ, Murray MS, Johnson LC, et al. (2005). "Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin". Biochemistry. 44 (24): 8634–42. doi:10.1021/bi050131i. PMC 3928543 . PMID 15952770.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID 16381901.
Jeong W, Park SJ, Chang TS, et al. (2006). "Molecular mechanism of the reduction of cysteine sulfinic acid of peroxiredoxin to cysteine by mammalian sulfiredoxin". J. Biol. Chem. 281 (20): 14400–7. doi: 10.1074/jbc.M511082200 . PMID 16565085.
Findlay VJ, Townsend DM, Morris TE, et al. (2006). "A novel role for human sulfiredoxin in the reversal of glutathionylation". Cancer Res. 66 (13): 6800–6. doi:10.1158/0008-5472.CAN-06-0484. PMC 6361143 . PMID 16818657.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000271303 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032802 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SRXN1 sulfiredoxin 1 homolog (S. Cerevisiae)".

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SRXN1

Related Research Articles

References

Further reading