SRXN1

SRXN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XW4, 1YZS, 2B6F, 2RII, 3CYI, 3HY2
Identifiers
Aliases	SRXN1 , C20orf139, Npn3, SRX, SRX1, sulfiredoxin 1
External IDs	OMIM: 617583; MGI: 104971; HomoloGene: 32722; GeneCards: SRXN1; OMA:SRXN1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20p13 Start 646,615 bp [1] End 653,200 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 G3 Start 151,947,436 bp [2] End 151,953,296 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans left adrenal gland left adrenal cortex right adrenal cortex stromal cell of endometrium left ventricle right auricle of heart gastrocnemius muscle apex of heart right frontal lobe Top expressed in adrenal gland ileum jejunum duodenum pituitary gland pontine nuclei blood gastrula lateral geniculate nucleus ankle joint More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding oxidoreductase activity antioxidant activity ATP binding oxidoreductase activity, acting on a sulfur group of donors sulfiredoxin activity protein binding Cellular component cytoplasm cytosol Biological process cellular oxidant detoxification response to oxidative stress cellular response to oxidative stress Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 140809 76650 Ensembl ENSG00000271303 ENSMUSG00000032802 UniProt Q9BYN0 Q9D975 RefSeq (mRNA) NM_080725 NM_029688 RefSeq (protein) NP_542763 NP_083964 Location (UCSC) Chr 20: 0.65 – 0.65 Mb Chr 2: 151.95 – 151.95 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sulfiredoxin-1 is a protein that in humans is encoded by the SRXN1 gene. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000271303 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032802 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SRXN1 sulfiredoxin 1 homolog (S. Cerevisiae)".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. Bibcode:2001Sci...291.1304V. doi: 10.1126/science.1058040 . PMID   11181995.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Chang TS, Jeong W, Woo HA, et al. (2005). "Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine". J. Biol. Chem. 279 (49): 50994–1001. doi: 10.1074/jbc.M409482200 . PMID   15448164.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Woo HA, Jeong W, Chang TS, et al. (2005). "Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins". J. Biol. Chem. 280 (5): 3125–8. doi: 10.1074/jbc.C400496200 . PMID   15590625.
• Jönsson TJ, Murray MS, Johnson LC, et al. (2005). "Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin". Biochemistry. 44 (24): 8634–42. doi:10.1021/bi050131i. PMC   3928543 . PMID   15952770.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Jeong W, Park SJ, Chang TS, et al. (2006). "Molecular mechanism of the reduction of cysteine sulfinic acid of peroxiredoxin to cysteine by mammalian sulfiredoxin". J. Biol. Chem. 281 (20): 14400–7. doi: 10.1074/jbc.M511082200 . PMID   16565085.
• Findlay VJ, Townsend DM, Morris TE, et al. (2006). "A novel role for human sulfiredoxin in the reversal of glutathionylation". Cancer Res. 66 (13): 6800–6. doi:10.1158/0008-5472.CAN-06-0484. PMC   6361143 . PMID   16818657.