SSX5

SSX5
Identifiers
Aliases	SSX5 , SSX family member 5
External IDs	OMIM: 300327 HomoloGene: 137346 GeneCards: SSX5
Gene location (Human)
Chr.	X chromosome (human)
End	48,196,795 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; pharynx; ; human musculoskeletal system; ; thymus; ; placenta; ; renal cortex; ; muscular system; ; muscle; ; muscle; ; testicle;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; transcription corepressor activity ; nucleic acid binding ;
Cellular component	intracellular anatomical structure ; nucleus ;
Biological process	negative regulation of nucleic acid-templated transcription ; regulation of transcription, DNA-templated ; transcription, DNA-templated ;
	Sources:Amigo / QuickGO
Orthologs
	6758
	n/a
	ENSG00000165583
	n/a
	O60225
	n/a
	NM_021015 ; NM_175723
	n/a
	NP_066295 ; NP_783729
	n/a
	Wikidata
View/Edit Human

Last updated January 13, 2024

Protein SSX5 is a protein that in humans is encoded by the SSX5 gene.^[3]

Function

The product of this gene belongs to the family of highly homologous synovial sarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) chromosomal translocation characteristically found in all synovial sarcomas. This gene appears not to be involved in this type of translocation. Two transcript variants encoding distinct isoforms have been identified for this gene.^[3]

Related Research Articles

A synovial sarcoma is a rare form of cancer which occurs primarily in the extremities of the arms or legs, often in proximity to joint capsules and tendon sheaths. It is a type of soft-tissue sarcoma.

Ectopic is a word used with a prefix, ecto, meaning “out of place.” Ectopic expression is an abnormal gene expression in a cell type, tissue type, or developmental stage in which the gene is not usually expressed. The term ectopic expression is predominantly used in studies using metazoans, especially in Drosophila melanogaster for research purposes.

Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene.

Cancer/testis antigen 1 also known as LAGE2 or LAGE2B is a protein that in humans is encoded by the CTAG1B gene. It is most often referenced by its alias NY-ESO-1.

Glypican-3 is a protein that, in humans, is encoded by the GPC3 gene. The GPC3 gene is located on human X chromosome (Xq26) where the most common gene encodes a 70-kDa core protein with 580 amino acids. Three variants have been detected that encode alternatively spliced forms termed Isoforms 1 (NP_001158089), Isoform 3 (NP_001158090) and Isoform 4 (NP_001158091).

Melanoma-associated antigen 3 (MAGE-A3) is a protein that in humans is encoded by the MAGEA3 gene.

Protein SSX2 is a protein that in humans is encoded by the SSX2 gene.

Protein SSXT is a protein that in humans is encoded by the SS18 gene.

Melanoma-associated antigen 4 is a protein that in humans is encoded by the MAGEA4 gene.

Protein SSX1 is a protein that in humans is encoded by the SSX1 gene.

Protein SSX4 is a protein that in humans is encoded by the SSX4 gene.

Protein AF-10 is a protein that in humans is encoded by the MLLT10 gene.

Immunoglobulin-binding protein 1 is a protein that in humans is encoded by the IGBP1 gene.

Melanoma-associated antigen C2 is a protein that in humans is encoded by the MAGEC2 gene.

Fetal and Adult Testis-Expressed 1, encoded by the FATE1 gene in humans, is a protein identified as a cancer-testis antigen (CTA) in hepatocellular carcinomas and gastric and colon cancers. It is testis-specific in the fetus. In adults, it is expressed predominantly in the testis and adrenal glands, with some expression in the lungs, heart, kidneys and throughout the brain.

SS18-like protein 1 is a protein that in humans is encoded by the SS18L1 gene.

Synovial sarcoma, X breakpoint (SSX) refers to a group of genes rearranged in synovial sarcoma.

Cancer/testis (CT) antigens are a group of proteins united by their importance in development and in cancer immunotherapy. In general, expression of these proteins is restricted to male germ cells in the adult animal. However, in cancer these developmental antigens are often re-expressed and can serve as a locus of immune activation. Thus, they are often classified as tumor antigens. The expression of CT antigens in various malignancies is heterogeneous and often correlates with tumor progression. CT antigens have been described in melanoma, liver cancer, lung cancer, bladder cancer, and pediatric tumors such as neuroblastoma. Gametogenesis offers an important role for many of these antigens in the differentiation, migration, and cell division of primordial germ cells, spermatogonia spermatocytes and spermatids. Because of their tumor-restricted expression and strong in vivo immunogenicity, CT antigens are identified as ideal targets for tumor specific immunotherapeutic approaches and prompted the development of several clinical trials of CT antigens-based vaccine therapy. CT antigens have been found to have at least 70 families so far, including about 140 members, most of which are expressed during spermatogenesis. Their expression are mainly regulated by epigenetic events, specifically, DNA methylation.

SSX family member 6, pseudogene is a protein that in humans is encoded by the SSX6 gene.

YTH N6-methyladenosine RNA binding protein 2 is a protein that in humans is encoded by the YTHDF2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000165583 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: SSX5 synovial sarcoma, X breakpoint 5".

dos Santos NR, de Bruijn DR, van Kessel AG (January 2001). "Molecular mechanisms underlying human synovial sarcoma development". Genes, Chromosomes & Cancer. 30 (1): 1–14. doi:10.1002/1098-2264(2000)9999:9999<::AID-GCC1056>3.0.CO;2-G. PMID 11107170. S2CID 24403558.
Gure AO, Türeci O, Sahin U, Tsang S, Scanlan MJ, Jäger E, Knuth A, Pfreundschuh M, Old LJ, Chen YT (September 1997). "SSX: a multigene family with several members transcribed in normal testis and human cancer". International Journal of Cancer. 72 (6): 965–71. doi:10.1002/(SICI)1097-0215(19970917)72:6<965::AID-IJC8>3.0.CO;2-N. PMID 9378559. S2CID 21203036.
Chen CH, Chen GJ, Lee HS, Huang GT, Yang PM, Tsai LJ, Chen DS, Sheu JC (March 2001). "Expressions of cancer-testis antigens in human hepatocellular carcinomas". Cancer Letters. 164 (2): 189–95. doi:10.1016/S0304-3835(01)00379-2. PMID 11179834.
de Bruijn DR, dos Santos NR, Kater-Baats E, Thijssen J, van den Berk L, Stap J, Balemans M, Schepens M, Merkx G, van Kessel AG (July 2002). "The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP". Genes, Chromosomes & Cancer. 34 (3): 285–98. doi:10.1002/gcc.10073. PMID 12007189. S2CID 11734893.
Güre AO, Wei IJ, Old LJ, Chen YT (October 2002). "The SSX gene family: characterization of 9 complete genes". International Journal of Cancer. 101 (5): 448–53. doi: 10.1002/ijc.10634 . PMID 12216073. S2CID 21174312.
Wu LQ, Lu Y, Wang XF, Lv ZH, Zhang B, Yang JY (July 2006). "Expression of cancer-testis antigen (CTA) in tumor tissues and peripheral blood of Chinese patients with hepatocellular carcinoma". Life Sciences. 79 (8): 744–8. doi:10.1016/j.lfs.2006.02.024. PMID 16546222.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000165583 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] 1 2 "Entrez Gene: SSX5 synovial sarcoma, X breakpoint 5".

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SSX5

Contents

Function

Related Research Articles

References

Further reading