ST13

ST13
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UZS
Identifiers
Aliases	ST13 , AAG2, FAM10A1, FAM10A4, HIP, HOP, HSPABP, HSPABP1, P48, PRO0786, SNC6, ST13 Hsp70 interacting protein
External IDs	OMIM: 606796 MGI: 1917606 HomoloGene: 2921 GeneCards: ST13
Gene location (Human)
Chr.	Chromosome 22 (human)
End	40,856,639 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	81,284,278 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; ganglionic eminence; ; stromal cell of endometrium; ; canal of the cervix; ; gallbladder; ; right adrenal gland; ; optic nerve; ; left adrenal gland; ; gastric mucosa; ; popliteal artery;
	Top expressed in
	pineal gland; ; retinal pigment epithelium; ; yolk sac; ; abdominal wall; ; mirror; ; dorsomedial hypothalamic nucleus; ; white adipose tissue; ; left lobe of liver; ; habenula; ; medial ganglionic eminence;
	More reference expression data
	n/a
Gene ontology
Molecular function	dATP binding ; unfolded protein binding ; protein-containing complex binding ; Hsp70 protein binding ; protein-macromolecule adaptor activity ; chaperone binding ; protein binding ; protein domain specific binding ; identical protein binding ; protein dimerization activity ;
Cellular component	extracellular exosome ; cytoplasm ; cytosol ; protein-containing complex ;
Biological process	protein homooligomerization ; protein folding ; negative regulation of protein refolding ; response to bacterium ; chaperone cofactor-dependent protein refolding ; protein homotetramerization ;
	Sources:Amigo / QuickGO
Orthologs
	6767
	70356
	ENSG00000100380
	ENSMUSG00000022403
	P50502
	Q99L47
	NM_003932 ; NM_001278589
	NM_133726
	NP_001265518 ; NP_003923
	NP_598487
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 19, 2023

Hsc70-interacting protein also known as suppression of tumorigenicity 13 (ST13) is a protein that in humans is encoded by the ST13 gene.^[5]^[6]^[7]

Function

The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that is a candidate tumor suppressor gene.^[7]

Related Research Articles

Hop, occasionally written HOP, is an abbreviation for Hsp70-Hsp90 Organizing Protein. It functions as a co-chaperone which reversibly links together the protein chaperones Hsp70 and Hsp90.

BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene.

Prostaglandin E synthase 3 (cytosolic) is an enzyme that in humans is encoded by the PTGES3 gene.

DnaJ homolog subfamily A member 3, mitochondrial, also known as Tumorous imaginal disc 1 (TID1), is a protein that in humans is encoded by the DNAJA3 gene on chromosome 16. This protein belongs to the DNAJ/Hsp40 protein family, which is known for binding and activating Hsp70 chaperone proteins to perform protein folding, degradation, and complex assembly. As a mitochondrial protein, it is involved in maintaining membrane potential and mitochondrial DNA (mtDNA) integrity, as well as cellular processes such as cell movement, growth, and death. Furthermore, it is associated with a broad range of diseases, including neurodegenerative diseases, inflammatory diseases, and cancers.

STUB1 is a human gene that codes for the protein CHIP.

Suppressor of tumorigenicity 14 protein, also known as matriptase, is a protein that in humans is encoded by the ST14 gene. ST14 orthologs have been identified in most mammals for which complete genome data are available.

DnaJ homolog subfamily B member 1 is a protein that in humans is encoded by the DNAJB1 gene.

Macrophage scavenger receptor 1, also known as MSR1, is a protein which in humans is encoded by the MSR1 gene. MSR1 has also been designated CD204.

AH receptor-interacting protein (AIP) also known as aryl hydrocarbon receptor-interacting protein, immunophilin homolog ARA9, or HBV X-associated protein 2 (XAP-2) is a protein that in humans is encoded by the AIP gene. The protein is a member of the FKBP family.

DnaJ homolog subfamily A member 1 is a protein that in humans is encoded by the DNAJA1 gene.

BAG family molecular chaperone regulator 3 is a protein that in humans is encoded by the BAG3 gene. BAG3 is involved in chaperone-assisted selective autophagy.

BAG family molecular chaperone regulator 2 is a protein that in humans is encoded by the BAG2 gene.

Heat shock protein 75 kDa, mitochondrial is a protein that in humans is encoded by the TRAP1 gene.

DnaJ homolog subfamily A member 2 is a protein that in humans is encoded by the DNAJA2 gene.

Low-density lipoprotein receptor-related protein 1B is a protein that in humans is encoded by the LRP1B gene.

BAG family molecular chaperone regulator 4 is a protein that in humans is encoded by the BAG4 gene.

BAG family molecular chaperone regulator 5 is a protein that in humans is encoded by the BAG5 gene.

DnaJ homolog subfamily B member 4 is a protein that in humans is encoded by the DNAJB4 gene.

Mitochondrial import receptor subunit TOM70 is a protein that in humans is encoded by the TOMM70A gene.

Transmembrane protein 158 is a protein that in humans is encoded by the TMEM158 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100380 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022403 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zhang Y, Cai X, Schlegelberger B, Zheng S (Mar 1999). "Assignment1 of human putative tumor suppressor genes ST13 (alias SNC6) and ST14 (alias SNC19) to human chromosome bands 22q13 and 11q24→q25 by in situ hybridization". Cytogenet Cell Genet. 83 (1–2): 56–7. doi:10.1159/000015125. PMID 9925927. S2CID 37163219.
↑ Prapapanich V, Chen S, Nair SC, Rimerman RA, Smith DF (Oct 1996). "Molecular cloning of human p48, a transient component of progesterone receptor complexes and an Hsp70-binding protein". Mol Endocrinol. 10 (4): 420–31. doi: 10.1210/mend.10.4.8721986 . PMID 8721986.
1 2 "Entrez Gene: ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)".

Prapapanich V, Chen S, Toran EJ, et al. (1996). "Mutational analysis of the hsp70-interacting protein Hip". Mol. Cell. Biol. 16 (11): 6200–7. doi:10.1128/MCB.16.11.6200. PMC 231623 . PMID 8887650.
Cao J, Cai X, Zheng L, et al. (1997). "Characterization of colorectal-cancer-related cDNA clones obtained by subtractive hybridization screening". J. Cancer Res. Clin. Oncol. 123 (8): 447–51. doi:10.1007/BF01372549. PMID 9292708. S2CID 42097617.
Mo Y, Zheng S, Shen D (1998). "[Differential expression of HSU17714 gene in colorectal cancer and normal colonic mucosa]". Zhonghua Zhong Liu Za Zhi. 18 (4): 241–3. PMID 9387309.
Johnson BD, Schumacher RJ, Ross ED, Toft DO (1998). "Hop modulates Hsp70/Hsp90 interactions in protein folding". J. Biol. Chem. 273 (6): 3679–86. doi: 10.1074/jbc.273.6.3679 . PMID 9452498.
Zheng S, Cai X, Cao J, et al. (1998). "Screening and identification of down-regulated genes in colorectal carcinoma by subtractive hybridization: a method to identify putative tumor suppressor genes". Chin. Med. J. 110 (7): 543–7. PMID 9594214.
Chen S, Smith DF (1999). "Hop as an adaptor in the heat shock protein 70 (Hsp70) and hsp90 chaperone machinery". J. Biol. Chem. 273 (52): 35194–200. doi: 10.1074/jbc.273.52.35194 . PMID 9857057.
Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID 10591208.
Morishima Y, Kanelakis KC, Silverstein AM, et al. (2000). "The Hsp organizer protein hop enhances the rate of but is not essential for glucocorticoid receptor folding by the multiprotein Hsp90-based chaperone system". J. Biol. Chem. 275 (10): 6894–900. doi: 10.1074/jbc.275.10.6894 . PMID 10702249.
Rajapandi T, Greene LE, Eisenberg E (2000). "The molecular chaperones Hsp90 and Hsc70 are both necessary and sufficient to activate hormone binding by glucocorticoid receptor". J. Biol. Chem. 275 (29): 22597–604. doi: 10.1074/jbc.M002035200 . PMID 10781595.
Agarraberes FA, Dice JF (2002). "A molecular chaperone complex at the lysosomal membrane is required for protein translocation". J. Cell Sci. 114 (Pt 13): 2491–9. doi:10.1242/jcs.114.13.2491. PMID 11559757.
Velten M, Gomez-Vrielynck N, Chaffotte A, Ladjimi MM (2002). "Domain structure of the HSC70 cochaperone, HIP". J. Biol. Chem. 277 (1): 259–66. doi: 10.1074/jbc.M106881200 . PMID 11687574.
Fan GH, Yang W, Sai J, Richmond A (2002). "Hsc/Hsp70 interacting protein (hip) associates with CXCR2 and regulates the receptor signaling and trafficking". J. Biol. Chem. 277 (8): 6590–7. doi: 10.1074/jbc.M110588200 . PMC 2665275 . PMID 11751889.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Nelson GM, Prapapanich V, Carrigan PE, et al. (2005). "The heat shock protein 70 cochaperone hip enhances functional maturation of glucocorticoid receptor". Mol. Endocrinol. 18 (7): 1620–30. doi: 10.1210/me.2004-0054 . PMID 15071092.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148 . PMID 15231748.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604 . PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000100380 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022403 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9925927-5] Zhang Y, Cai X, Schlegelberger B, Zheng S (Mar 1999). "Assignment1 of human putative tumor suppressor genes ST13 (alias SNC6) and ST14 (alias SNC19) to human chromosome bands 22q13 and 11q24→q25 by in situ hybridization". Cytogenet Cell Genet. 83 (1–2): 56–7. doi:10.1159/000015125. PMID 9925927. S2CID 37163219.

[pmid8721986-6] Prapapanich V, Chen S, Nair SC, Rimerman RA, Smith DF (Oct 1996). "Molecular cloning of human p48, a transient component of progesterone receptor complexes and an Hsp70-binding protein". Mol Endocrinol. 10 (4): 420–31. doi: 10.1210/mend.10.4.8721986 . PMID 8721986.

[entrez-7] 1 2 "Entrez Gene: ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)".

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[7]

ST13

Contents

Function

Related Research Articles

References

Further reading