ST6GALNAC2

ST6GALNAC2
Identifiers
Aliases	ST6GALNAC2 , SAITL1, SIAT7, SIAT7B, SIATL1, ST6GalNAII, STHM, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
External IDs	OMIM: 610137; MGI: 107553; HomoloGene: 4714; GeneCards: ST6GALNAC2; OMA:ST6GALNAC2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	76,586,956 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	116,585,694 bp
RNA expression pattern
	Top expressed in
	tibial nerve; ; right uterine tube; ; right testis; ; left testis; ; sural nerve; ; olfactory zone of nasal mucosa; ; skin of abdomen; ; blood; ; skin of leg; ; testicle;
	Top expressed in
	seminiferous tubule; ; superior surface of tongue; ; gallbladder; ; corneal stroma; ; right kidney; ; submandibular gland; ; choroid plexus of fourth ventricle; ; crypt of lieberkuhn of small intestine; ; human kidney; ; conjunctival fornix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glycosyltransferase activity ; transferase activity ; sialyltransferase activity ; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity ;
Cellular component	integral component of membrane ; Golgi apparatus ; membrane ; Golgi membrane ;
Biological process	sialylation ; oligosaccharide metabolic process ; O-glycan processing ; protein N-linked glycosylation via asparagine ; protein glycosylation ; protein O-linked glycosylation ; protein sialylation ;
	Sources:Amigo / QuickGO
Orthologs
	10610
	20446
	ENSG00000070731
	ENSMUSG00000057286
	Q9UJ37
	P70277
	NM_006456
	NM_009180
	NP_006447
	NP_033206
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 28, 2024

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 is an enzyme that in humans is encoded by the ST6GALNAC2 gene.^[5]^[6]

Related Research Articles

Beta-galactoside alpha-2,6-sialyltransferase 1 is an enzyme that in humans is encoded by the ST6GAL1 gene.

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Nascent-polypeptide-associated complex alpha polypeptide, also known as NACA, is a protein which in humans is encoded by the NACA gene.

Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase is an enzyme that in humans is encoded by the ST8SIA1 gene.

Alpha-1,2-mannosyltransferase ALG9 is an enzyme that in humans is encoded by the ALG9 gene.

Lactosylceramide alpha-2,3-sialyltransferase is an enzyme that in humans is encoded by the ST3GAL5 gene.

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase is an enzyme that in humans is encoded by the ST3GAL4 gene.

Sialic acid-binding Ig-like lectin 5 is a protein that in humans is encoded by the SIGLEC5 gene. SIGLEC5 has also been designated CD170.

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 is an enzyme that in humans is encoded by the B3GNT3 gene.

28S ribosomal protein S30, mitochondrial is a protein that in humans is encoded by the MRPS30 gene.

DGLUCY is a protein that in humans is encoded by the DGLUCY gene.

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4, also known as sialyltransferase 3C (SIAT3-C) or sialyltransferase 7D (SIAT7-D) is a sialyltransferase enzyme that in humans is encoded by the ST6GALNAC4 gene.

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B is an enzyme that in humans is encoded by the MGAT4B gene.

Polypeptide N-acetylgalactosaminyltransferase 6 is an enzyme that in humans is encoded by the GALNT6 gene.

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 is an enzyme that in humans is encoded by the ST6GALNAC1 gene. This enzyme adds a N-acetylneuraminic acid to an O-linked N-acetylgalactosamine (GalNAc) on a peptide/proteins with an α2-6 linkage to produce the sialyl-Tn antigen. It has been shown that the enzyme prefers threonine over serine containing GalNAc residues.

Galactose-3-O-sulfotransferase 4 is an enzyme that in humans is encoded by the GAL3ST4 gene.

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 is an enzyme that in humans is encoded by the ST6GALNAC6 gene.

COMM domain-containing protein 4 is a protein that in humans is encoded by the COMMD4 gene.

UDP-N-acetylglucosamine transferase subunit ALG13 homolog, also known as asparagine-linked glycosylation 13 homolog, is an enzyme that in humans is encoded by the ALG13 gene.

Radial spoke head protein 6 homolog A (RSPH6A) also known as radial spoke head-like protein 1 (RSHL1) is a protein that in humans is encoded by the RSPH6A gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000070731 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057286 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sotiropoulou G, Kono M, Anisowicz A, Stenman G, Tsuji S, Sager R (May 2002). "Identification and functional characterization of a human GalNAc [alpha]2,6-sialyltransferase with altered expression in breast cancer". Mol Med. 8 (1): 42–55. doi:10.1007/BF03402002. PMC 2039932 . PMID 11984005.
↑ "Entrez Gene: ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2".

Li GS, Zhu L, Zhang H, et al. (2007). "Variants of the ST6GALNAC2 promoter influence transcriptional activity and contribute to genetic susceptibility to IgA nephropathy". Hum. Mutat. 28 (10): 950–7. doi: 10.1002/humu.20543 . PMID 17480010. S2CID 7286057.
Raska M, Moldoveanu Z, Suzuki H, et al. (2007). "Identification and characterization of CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase in IgA1-producing cells". J. Mol. Biol. 369 (1): 69–78. doi:10.1016/j.jmb.2007.03.002. PMC 1995659 . PMID 17418236.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148 . PMID 15231748.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Samyn-Petit B, Krzewinski-Recchi MA, Steelant WF, et al. (2000). "Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells". Biochim. Biophys. Acta. 1474 (2): 201–11. doi:10.1016/s0304-4165(00)00020-9. PMID 10742600.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000070731 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057286 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11984005-5] Sotiropoulou G, Kono M, Anisowicz A, Stenman G, Tsuji S, Sager R (May 2002). "Identification and functional characterization of a human GalNAc [alpha]2,6-sialyltransferase with altered expression in breast cancer". Mol Med. 8 (1): 42–55. doi:10.1007/BF03402002. PMC 2039932 . PMID 11984005.

[entrez-6] "Entrez Gene: ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2".

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ST6GALNAC2

Contents

See also

Related Research Articles

References

Further reading