Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase

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alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
Identifiers
EC no. 2.4.3.3
CAS no. 71124-50-0
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In enzymology, an alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (EC 2.4.3.3) is an enzyme that catalyzes the chemical reaction

CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)- glycoprotein

Thus, the two substrates of this enzyme are CMP-N-acetylneuraminate and glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein, whereas its 3 products are CMP, glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-, and glycoprotein.

This enzyme belongs to the family of transferases, specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase. This enzyme participates in O-glycan biosynthesis and glycan structures - biosynthesis 1.

See also

Related Research Articles

<span class="mw-page-title-main">Sialyltransferase</span> Class of enzymes

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<span class="mw-page-title-main">ST6GALNAC4</span> Protein-coding gene in the species Homo sapiens

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4, also known as sialyltransferase 3C (SIAT3-C) or sialyltransferase 7D (SIAT7-D) is a sialyltransferase enzyme that in humans is encoded by the ST6GALNAC4 gene.

<span class="mw-page-title-main">ST6GALNAC1</span> Protein-coding gene in the species Homo sapiens

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 is an enzyme that in humans is encoded by the ST6GALNAC1 gene. This enzyme adds a N-acetylneuraminic acid to an O-linked N-acetylgalactosamine (GalNAc) on a peptide/proteins with an α2-6 linkage to produce the sialyl-Tn antigen. It has been shown that the enzyme prefers threonine over serine containing GalNAc residues.

<span class="mw-page-title-main">ST6GALNAC2</span> Gene in humans

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 is an enzyme that in humans is encoded by the ST6GALNAC2 gene.

α-N-Acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide 6-α-sialyltransferase is an enzyme with systematic name CMP-N-acetylneuraminate:N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)- N-acetyl-D-galactosaminide galactosamine-6-alpha-N-acetylneuraminyltransferase. This enzyme catalyses the following chemical reaction

References